Rhythm and Multisensoriality's Effects on the Motor Development in Children With Cerebral Palsy (APP-PaC)

Rhythm and the Multisensoriality's Effects on the Motor Development in Children With Cerebral Palsy

Cerebral palsy (CP) affects the motor function but also the cognitive function of the child. Physical activity brings motor and cognitive benefits and appears as an important aspect of the therapy that is offered to them.

The child is seating in front of a computer, seating comfortably on a chair during 1 hour. The experimental task consists in learning a sequence of taps on "Serial reaction time task" type buzzers (SRTT) in which the child must press a buzzer corresponding to one of the 4 squares that on the screen. The sequence corresponds to 10 steps in a particular order.

Study Overview

• Status: Unknown
• Conditions: Cerebral Palsy
• Intervention / Treatment: Other: luminous stimuli

Detailed Description

Cerebral palsy (CP) affects the motor function but also the cognitive function of the child. Physical activity brings motor and cognitive benefits and appears as an important aspect of the therapy that is offered to them. In particular, the learning of movements in the presence of multisensory rhythmic information seems to have beneficial effects at the cognitive and motor level. The present study aims to test the respective effects of rhythm and multisensoriality on motor learning in children with cerebral palsy.

The motor learning task is known as the "Serial Reaction Time Task" (SRTT). It consists in repeating a sequence of movements of the upper limbs using visual-spatial information alone (V). It will test the addition of synchronous auditory stimulation to visual information or rhythmic auditory stimulation(VAR), to contrast with a control condition with non-rhythmic auditory stimulation (VANR). The performance of the children will be measured by the reaction time (RT), its stability and the number of errors made throughout the motor learning.

The child is placed in front of a screen on which 4 luminous stimuli are presented on a horizontal plane. Four buzzers are placed in front of him, each buzzer corresponds to the position of a stimulus. The stimuli light up in a predetermined sequence (10 positions) and the child must press the buzzer corresponding to the position of the stimulus that comes on. Four blocks of 5 sequences are repeated to test the general learning (B1 to B4) and then a block of random stimuli is presented to test the specific learning of the sequence (B5).

• Study Type: Interventional
• Enrollment (Anticipated): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Toulouse, France, 31052
    • Recruiting
    • University Hospital Toulouse
    • Contact: Philippe Marque, MD; Phone Number: 33 5-61-32-28-01; Email: marque.ph@chu-toulouse.frmarque.ph@chu-toulouse.fr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 6 years to 14 years (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

For all children:

• Age between 6 and 14 years
• Obtaining the informed consent of the person possessing parental authority for all children

For children with Cerebral Palsy:

• Diagnosis of spastic cerebral palsy of levels GMFCS I to IV
• Ability to press buzzers with the palm of the hand, Manual Ability Classification System (MASC) I to IV
• Ability to understand instructions ("tap a buzzer along with a picture or sound") (investigator's appreciation)

For control children: no pathology diagnosed

Exclusion Criteria:

For all children:

• Children with a characteristic psychiatric pathology.
• Disorders of the understanding
• Hearing deficiency
• Uncorrected visual impairment

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Children with Cerebral Palsy (PC); Serial reaction time task: repeating a sequence of movements according to the luminous stimuli	Other: luminous stimuli; The child is placed in front of a screen on which 4 luminous stimuli are presented on a horizontal plane. Four buzzers are placed in front of him, each buzzer corresponds to the position of a stimulus. Child had to push the buzzer corresponding to the place of the luminous stimuli.; Other Names: Serial reaction time task
Active Comparator: Control Group; Serial reaction time task: of movements according to the luminous stimuli	Other: luminous stimuli; The child is placed in front of a screen on which 4 luminous stimuli are presented on a horizontal plane. Four buzzers are placed in front of him, each buzzer corresponds to the position of a stimulus. Child had to push the buzzer corresponding to the place of the luminous stimuli.; Other Names: Serial reaction time task

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time reaction (TR)	- The TR is the Reaction Time between the appearance of the stimulus and the response. It represents the speed with which the child pressed the key in response to the lighting of the square.	1 hour

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of errors	The number of errors corresponds to pressing a key that does not correspond to the position of the lit square.	1 hour

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Multisensory integration degree	Multisensory integration degree evaluated in pre-test	1 hour
Degree of synchronization	Degree of synchronization evaluated in pre-test	1 hour

Collaborators and Investigators

• Sponsor: University Hospital, Toulouse
• Collaborators: Institut National de la Santé Et de la Recherche Médicale, France
• Investigators: Principal Investigator: Philippe Marque, MD, University Hospital, Toulouse

Study record dates

Study Major Dates

• Study Start (Actual): February 15, 2018
• Primary Completion (Anticipated): August 1, 2020
• Study Completion (Anticipated): August 1, 2020

Study Registration Dates

• First Submitted: February 13, 2018
• First Submitted That Met QC Criteria: February 14, 2018
• First Posted (Actual): February 22, 2018

Study Record Updates

• Last Update Posted (Actual): October 10, 2019
• Last Update Submitted That Met QC Criteria: October 9, 2019
• Last Verified: October 1, 2019

More Information

Terms related to this study

• Keywords: rhythm; serial Reaction Time Task
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Brain Damage, Chronic; Cerebral Palsy
• Other Study ID Numbers: RC31/17/0158; 2017-A01969-44 (Other Identifier: Toulouse Hospital)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No