- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03492346
Limb Girdle Muscular Dystrophy Type 2E Recruitment Study
Study Overview
Status
Conditions
Detailed Description
This is a longitudinal observational study. It is a 24-month study with the possibility of extending the data time points. Visits will occur monthly. However, at the discretion of the PI, subjects may not be required to return monthly. These subjects may return at intervals ranging from 2 months to a max of 6 months apart.
In the situation that the subjects would fall out of the inclusion criteria or not be eligible for the LGMD2E gene therapy trial, they will be given the opportunity to roll over into the Natural History for LGMD (IRB17-01086). If a subject is invited to screen for the gene therapy trial they will discontinue this trial. By being in this study, it is not a guarantee that subjects will be invited to screen for the LGMD2E gene therapy trial.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
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Ohio
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Columbus, Ohio, United States, 43205
- Recruiting
- Nationwide Children's Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
- Confirmed LGMD2E diagnosis by genetic testing or
- Suspected of having LGMD type 2E due to symptoms and a diagnosed family member or a member of a community with a large population of one of these two types
Description
Inclusion Criteria:
- Age 3-15 inclusive
- Males or females of any ethnic group
- SGCB DNA gene mutations at both alleles or suspected to have LGMD2E based on family and medical history. If suspected, genetic testing will be performed to confirm diagnosis.
- Weakness demonstrated based on history of difficulty running, jumping and climbing stairs
- Ability to complete 100MW timed test within 30-90% predicted
- Perform assessments to the best of their ability with reliable results as deemed by the evaluator.
- Ability to attend scheduled appointments
- Ability to provide informed consent (or assent for ages 9-15)
Exclusion Criteria:
- Confirmed diagnosis of neuromuscular disorder other than LGMD2E
- Has a medical condition or extenuating circumstance that, in the opinion of the investigator, might compromise the subject's ability to comply with the protocol required testing or procedures or compromise the subject's wellbeing, safety, or clinical interpretability
- Subjects with AAVrh74 binding antibody titers > 1:400 as determined by ELISA immunoassay. If endpoint titer is positive at screening, testing may be repeated in 1 month. Antibody testing will be performed on a separate study (IRB17-01101).
- Diagnosis of (or ongoing treatment for) an autoimmune disease
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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LGMD2E Subject Population
Individuals:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Baseline Measurements
Time Frame: 2 years
|
Establish baseline measurements for potential subjects that may be enrolled into a gene therapy trial.
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2 years
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Disease Progression
Time Frame: 2 years
|
Better define the rate of disease progression and skeletal muscle involvement
|
2 years
|
Registry
Time Frame: 2 years
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Generate a registry of well-characterized LGMD2E patients
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2 years
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Collaborators and Investigators
Sponsor
Collaborators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- IRB18-00224
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Limb-Girdle Muscular Dystrophy, Type 2E
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Linda Pax LowesRecruitingLimb-Girdle Muscular Dystrophy Type 2A | Limb-Girdle Muscular Dystrophy, Type 2EUnited States
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Sarepta Therapeutics, Inc.Active, not recruiting
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University Hospital of North NorwayUniversity of Tromso; Norwegian Muscle Disease Association (FFM); Norwegian National... and other collaboratorsActive, not recruitingMuscular Dystrophies | Limb Girdle Muscular Dystrophy | Limb Girdle Muscular Dystrophy, Type 2I | Limb Girdle Muscular Dystrophy R9 FKRP-relatedNorway
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ML Bio Solutions, Inc.RecruitingLimb-Girdle Muscular Dystrophy Type 2I (LGMD2I)United States, Netherlands, United Kingdom, Norway, Italy, Denmark, Australia
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Virginia Commonwealth UniversityUniversity of Colorado, Denver; Washington University School of Medicine; University... and other collaboratorsRecruitingLimb Girdle Muscular Dystrophy | Calpain-3 Deficiency Limb Girdle Muscular Dystrophy Type 2A | Limb Girdle Muscular Dystrophy Type R1 | LGMD2AUnited States, United Kingdom
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Sarepta Therapeutics, Inc.Active, not recruitingLimb-Girdle Muscular Dystrophy, Type 2EUnited States
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Rigshospitalet, DenmarkCompletedBecker Muscular Dystrophy | Limb-Girdle Muscular Dystrophy Type 2IDenmark
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Cooperative International Neuromuscular Research...Carolinas Medical Center lead study siteCompletedBecker Muscular Dystrophy | Limb-Girdle Muscular Dystrophy, Type 2A (Calpain-3 Deficiency) | Limb-Girdle Muscular Dystrophy, Type 2B (Miyoshi Myopathy, Dysferlin Deficiency) | Limb-Girdle Muscular Dystrophy, Type 2I (FKRP-deficiency)United States
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IRCCS San Camillo, Venezia, ItalyUniversita di Verona; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico and other collaboratorsEnrolling by invitationCalpain-3 Deficiency Limb Girdle Muscular Dystrophy Type 2AItaly
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Politecnico di MilanoIRCCS Eugenio Medea; Villa Beretta Rehabilitation CenterCompletedMuscular Dystrophies | Muscular Dystrophy, Duchenne | Muscular Dystrophy, Becker | Muscular Dystrophy, Limb-Girdle Type 2Italy