- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03578562
Targeted Exercise and Changes in Femoroacetabular Impingement in Symptomatic Patients With Acetabular Retroversion (TILT-FAI)
A Prospective Cohort Study on Targeted Exercise and Changes in Femoroacetabular Impingement in Symptomatic Patients With Acetabular Retroversion (TILT-FAI)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Acetabular retroversion is a variation of hip dysplasia, reported in the normal population from 6 % to 48 %, enhancing the risk of femoroacetabular impingement (FAI) in especially hip flexion and is associated with pain, reduced level of function, decreased health-related quality of life and early development of osteoarthritis (OA) of the hip. A higher degree of anterior pelvic tilt increases the risk of FAI and especially in standing, sitting and squatting positions it has been found to correlate with FAI. Periacetabular osteotomy (Ganz osteotomy) is performed as a surgical joint preserving reorientation of the entire acetabulum with a subsequently long period of rehabilitation. There is currently no existing alternative (i.e. non-surgical) treatment to surgery for this patient group. Therefore, the objective of this study is to test a targeted training intervention aiming at reducing anterior pelvic tilt and improve hip joint function in patients with symptomatic acetabular retroversion.
A prospective cohort study of 40 patients will undergo an 8-week targeted exercise intervention executed as progressive home-based training with supervised booster-sessions. Patients (18 to 40 years) with acetabular retroversion and anterior pelvic tilt not eligible for surgery (Ganz osteotomy) will be recruited from the outpatient clinic.
Time points for testing are at 1) minus 8-weeks (beginning of control-period) 2) baseline (beginning of training period) 3) plus 8-weeks (end of training period) and 4) plus 26 weeks from baseline (follow up).
The primary outcome measure is self-perceived level of hip related pain (HAGOS questionnaire subscale). Secondary outcome measures are self-perceived level of function and quality of life (remaining HAGOS-subscales), EQ-5D-3Levels questionnaire and radiographic degree of pelvic tilt in standing posture (EOS-scanning). Explorative outcome measures include additional radiographic measurements, patient-reported outcome measurements (PROM´s), functional testing and physical performance. The primary endpoint for assessing the outcome of the intervention will be 8 weeks after start of intervention. At 26-week follow up, only the PROM´s will be applied. All participants must fill in a mandatory exercise related dairy concerning adherence, level of pain and potential adverse events.
The study is approved by the Regional Committees on Health Research Ethics for Southern Denmark, Project ID: S-20160072 Forty participants in total will be enrolled from the hip outpatient clinic at Odense University Hospital, Denmark. Paired means sample size calculation = 36 (10 % pre-posttest difference on HAGOS pain-subscale, SD=20.6, alpha = 0.05, power = 80 %), plus 10 % dropout = 4.
A list generated of 20 randomly found numbers from 1-40 will be used to select participants to be investigated in the motion laboratory. The number on the list corresponds to the order the participants are recruited into the study. In the motion laboratory, the explorative outcomes Functional testing (3D motion capture) and Physical performance (isometric muscle strength, joint range-of-motion, and single-leg hop for distance) will be tested.
To our knowledge, this is the first study investigating a targeted training intervention aiming at reducing FAI related pain, anterior pelvic tilt and improve hip joint function in patients with acetabular retroversion. Consequently, the study will provide knowledge that may help to develop non-surgical treatment strategies for this group of patients.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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-
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Odense C., Denmark, 5000
- University of Southern Denmark - Odense University Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Diagnosed from a standard standing anterior-posterior pelvic radiograph with acetabular retroversion due to cross-over-sign and posterior-wall-sign
- Not eligible for Ganz osteotomy
- Ability to take part in the intervention
Exclusion Criteria:
- Having a Pelvic Tilt Ratio greater than 0.5, (the height of the obturator foramen divided by the height of the lesser pelvis) indicating posterior pelvic tilt, assessed from a standard standing AP-pelvic radiograph
- Radiographic sign of hip osteoarthritis (< 2mm. joint space),
- Previous lumbar, pelvic or hip related operations
- Conditions not allowing exercise therapy
- Body mass index (BMI) above 35
- Not understanding spoken and/or written Danish language
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Targeted training intervention
An 8-week progressive homebased training intervention with supervised booster-sessions
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An 8-week progressive homebased training intervention with supervised booster-sessions
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
HAGOS questionnaire (pain subscale)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention) and 26 weeks (follow up from baseline)
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Change in The Copenhagen Hip and Groin Outcome Score (HAGOS) questionnaire pain subscale. Standardized answer options are given (5 Likert boxes) and each question gets a score from 0 to 4, where 0 indicates no problem. The scores from each subscale are calculated as the sum of the items included. Raw scores are then transformed to a 0-100 scale, with zero representing extreme hip and/or groin problems and 100 representing no hip and/or groin problems. |
Minus 8-weeks (control), baseline, 8-weeks (post-intervention) and 26 weeks (follow up from baseline)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
HAGOS questionnaire (the remaining five subscales)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention) and 26 weeks (follow up from baseline)
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Change in the remaining five HAGOS-subscales (Symptoms, Physical function in daily living, Physical function in Sport and Recreation, Participation in Physical Activities and hip and/or groin-related Quality of Life). Standardized answer options are given (5 Likert boxes) and each question gets a score from 0 to 4, where 0 indicates no problem. The scores from each subscale are calculated as the sum of the items included. Raw scores are then transformed to a 0-100 scale, with zero representing extreme hip and/or groin problems and 100 representing no hip and/or groin problems. |
Minus 8-weeks (control), baseline, 8-weeks (post-intervention) and 26 weeks (follow up from baseline)
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EQ-5D-3Levels questionnaire
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention) and 26 weeks (follow up from baseline).
|
Change in the European Quality of Life - 5 Dimensions (EQ-5D-3Levels) questionnaire, Danish version.
For each dimension (Mobility, Self-Care, Usual Activities, Pain/Discomfort, Anxiety/Depression) standardized answer options are divided in levels of perceived problems (3 Likert boxes): Level 1: indicating no problem, Level 2: indicating some problems, Level 3: indicating extreme problems.
A unique health state is defined by combining the selected level from each of the 5 dimensions.
In addition, the overall health state the actual day is marked on a numeric scale on which the best state is marked 100 and the worst state is marked 0.
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention) and 26 weeks (follow up from baseline).
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Radiographic measurement of pelvic tilt (SCJ - Symphysis distance)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in the degree of pelvic tilt measured in the frontal plane as the distance (in mm) from the sacro-coccygeal joint (SCJ) to the upper border of the pubic symphysis (standing EOS scanning)
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Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Global Perceived Effect anchor-question
Time Frame: 8-weeks (post-intervention) and 26 weeks (follow up from baseline)
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Changed from baseline on a 7-point Likert scale: ´much better, better, little better, unchanged, little worse, worse, much worse'.
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8-weeks (post-intervention) and 26 weeks (follow up from baseline)
|
Oxford 12-item Hip Score (OHS) questionnaire, Danish version
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention) and 26 weeks (follow up from baseline)
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Change in Oxford Hip Score (OHS) questionnaire.
Standardized answer options are given (5 Likert boxes) and each question gets a score from 1 to 5, where 1 indicates no problem.
The score is calculated as the sum of the 12 questions.
The score can therefore be 12-60.
The higher the score, the lower the function level.
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention) and 26 weeks (follow up from baseline)
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UCLA activity scale
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention) and 26 weeks (follow up from baseline).
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Change in the University of California Los Angeles activity-level rating (UCLA activity scale), Danish version.
On a 10-point scale, the option is marked that matches the level of intensity and frequency of physical activity best, where 1 ="Wholly inactive: depend on others, cannot leave residence, and 10 =" Regularly participates in impact sports".
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention) and 26 weeks (follow up from baseline).
|
Radiographic measurement of pelvic tilt (pelvic tilt ratio)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in pelvic tilt ratio measured in the frontal plane (standing EOS scanning) and calculated as the centrally height (in mm) of the obturator foramens divided by the centrally height (in mm) of the lesser pelvis (the distance from the two lower margins of the sacroiliac joint to the upper border of the two obturator foramens).
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Radiographic measurement of pelvic tilt (sagittal plane)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in pelvic tilt (in degrees) measured in the sagittal plane (standing EOS scanning) as the angle between a horizontal line and a line connecting the upper border of the symphysis with the sacral promontory.
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Radiographic measurements of pelvic parameters (Pelvic Incidence)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in Pelvic Incidence (in degrees) measured as the angle between the line joining the hip axis and the center of the S1 end-plate and the line orthogonal to the S1 end-plate (standing EOS scanning)
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Radiographic measurements of pelvic parameters (Pelvic Tilt)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in Pelvic Tilt (in degrees) measured as the angle between the line joining the hip axis and the center of the S1 end-plate and a reference vertical line (standing EOS scanning)
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Radiographic measurements of pelvic parameters (Sacral Slope)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in Sacral Slope (in degrees) measured as the angle between the line along the S1 end-plate and a reference horizontal line (standing EOS scanning)
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Radiographic parameters of acetabular retroversion (Cross-Over Sign)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in Cross-Over Sign (yes/no) (standing EOS scanning)
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Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Radiographic parameters of acetabular retroversion (Cross-Over Ratio)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in Acetabular Cross-Over Ratio (percent) (standing EOS scanning)
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Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Radiographic parameters of acetabular retroversion (Posterior Wall Sign)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in Posterior Wall Sign (yes/no) (standing EOS scanning)
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Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Radiographic parameters of acetabular retroversion (Posterior Wall Ratio)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in Posterior Wall Ratio (percent) (standing EOS scanning)
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Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Radiographic parameters of acetabular retroversion (Ischial Spine Sign)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in Ischial Spine Sign (yes/no) (standing EOS scanning)
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Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Physical performance (hip muscle strength)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in maximal isometric hip extension, flexion and abduction muscle strength (in Nm using dynamometry)
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Physical performance (abdominal muscle strength)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in maximal isometric abdominal muscle strength (in Nm using dynamometry)
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Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Physical performance (hip ROM)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in hip extension range-of-motion (in degrees using goniometry)
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Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Physical performance (lumbar spine ROM)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
|
Change in lumbar spine flexion range-of-motion (in cm.
using Schobers test)
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Physical performance (Single-leg hop for distance)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention).
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Change in the horizontal single-leg hop distance (in cm) from the toe in the starting position to the heel in the landing position.
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Minus 8-weeks (control), baseline, 8-weeks (post-intervention).
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Functional test (3D Gait analysis - kinetics)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in peak- and mean hip joint moments (in Nm) using 3D Vicon motion capture analysis
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Functional test (3D Gait analysis - kinematics)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
|
Change in hip joint range-of-motion (in degrees) using 3D Vicon motion capture analysis
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Functional test (3D deep squat analysis - kinetics)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
|
Change in peak- and mean hip joint moments (in Nm) using 3D Vicon motion capture analysis
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
|
Functional test (3D deep squat analysis - kinematics)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
|
Change in hip joint range-of-motion (in degrees) using 3D Vicon motion capture analysis
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
|
Functional test (3D deep squat analysis, with heel support - kinetics)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
|
Change in peak- and mean hip joint moments (in Nm) using 3D Vicon motion capture analysis
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
|
Functional test (3D deep squat analysis, with heel support - kinematics)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in hip joint range-of-motion (in degrees) using 3D Vicon motion capture analysis
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Functional test (3D counter movement jump analysis, unilateral - kinetics)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in peak- and mean hip joint moments (in Nm) using 3D Vicon motion capture analysis
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Functional test (3D counter movement jump analysis, unilateral - kinematics)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Change in hip joint range-of-motion (in degrees) using 3D Vicon motion capture analysis
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
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Functional test (3D counter movement jump analysis, bilateral - kinetics)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
|
Change in peak- and mean hip joint moments (in Nm) using 3D Vicon motion capture analysis
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
|
Functional test (3D counter movement jump analysis, bilateral - kinematics)
Time Frame: Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
|
Change in hip joint range-of-motion (in degrees) using 3D Vicon motion capture analysis
|
Minus 8-weeks (control), baseline, 8-weeks (post-intervention)
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Anders F Brekke, PT, MSc, University of Southern Denmark
Publications and helpful links
General Publications
- Ganz R, Parvizi J, Beck M, Leunig M, Notzli H, Siebenrock KA. Femoroacetabular impingement: a cause for osteoarthritis of the hip. Clin Orthop Relat Res. 2003 Dec;(417):112-20. doi: 10.1097/01.blo.0000096804.78689.c2.
- Ross JR, Nepple JJ, Philippon MJ, Kelly BT, Larson CM, Bedi A. Effect of changes in pelvic tilt on range of motion to impingement and radiographic parameters of acetabular morphologic characteristics. Am J Sports Med. 2014 Oct;42(10):2402-9. doi: 10.1177/0363546514541229. Epub 2014 Jul 24.
- Ganz R, Klaue K, Vinh TS, Mast JW. A new periacetabular osteotomy for the treatment of hip dysplasias. Technique and preliminary results. Clin Orthop Relat Res. 1988 Jul;(232):26-36.
- Reynolds D, Lucas J, Klaue K. Retroversion of the acetabulum. A cause of hip pain. J Bone Joint Surg Br. 1999 Mar;81(2):281-8. doi: 10.1302/0301-620x.81b2.8291.
- Ezoe M, Naito M, Inoue T. The prevalence of acetabular retroversion among various disorders of the hip. J Bone Joint Surg Am. 2006 Feb;88(2):372-9. doi: 10.2106/JBJS.D.02385.
- Werner CM, Copeland CE, Ruckstuhl T, Stromberg J, Seifert B, Turen CH. Prevalence of acetabular dome retroversion in a mixed race adult trauma patient population. Acta Orthop Belg. 2008 Dec;74(6):766-72.
- Langlais F, Lambotte JC, Lannou R, Gedouin JE, Belot N, Thomazeau H, Frieh JM, Gouin F, Hulet C, Marin F, Migaud H, Sadri H, Vielpeau C, Richter D. Hip pain from impingement and dysplasia in patients aged 20-50 years. Workup and role for reconstruction. Joint Bone Spine. 2006 Dec;73(6):614-23. doi: 10.1016/j.jbspin.2006.09.001. Epub 2006 Oct 25.
- Rylander JH, Shu B, Andriacchi TP, Safran MR. Preoperative and postoperative sagittal plane hip kinematics in patients with femoroacetabular impingement during level walking. Am J Sports Med. 2011 Jul;39 Suppl:36S-42S. doi: 10.1177/0363546511413993.
- Clohisy JC, Baca G, Beaule PE, Kim YJ, Larson CM, Millis MB, Podeszwa DA, Schoenecker PL, Sierra RJ, Sink EL, Sucato DJ, Trousdale RT, Zaltz I; ANCHOR Study Group. Descriptive epidemiology of femoroacetabular impingement: a North American cohort of patients undergoing surgery. Am J Sports Med. 2013 Jun;41(6):1348-56. doi: 10.1177/0363546513488861. Epub 2013 May 13.
- Riviere C, Hardijzer A, Lazennec JY, Beaule P, Muirhead-Allwood S, Cobb J. Spine-hip relations add understandings to the pathophysiology of femoro-acetabular impingement: A systematic review. Orthop Traumatol Surg Res. 2017 Jun;103(4):549-557. doi: 10.1016/j.otsr.2017.03.010. Epub 2017 Apr 1.
- Schwarz T, Benditz A, Springorum HR, Matussek J, Heers G, Weber M, Renkawitz T, Grifka J, Craiovan B. Assessment of pelvic tilt in anteroposterior radiographs by means of tilt ratios. Arch Orthop Trauma Surg. 2018 Aug;138(8):1045-1052. doi: 10.1007/s00402-018-2931-z. Epub 2018 Apr 12.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1- Brekke
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Access Criteria
IPD Sharing Supporting Information Type
- Study Protocol
- Statistical Analysis Plan (SAP)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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