- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03608228
Invasive Approach to Model Human Cortex-Basal Ganglia Action-Regulating Networks
September 29, 2021 updated by: University of California, Los Angeles
The brain networks controlling movement are complex, involving multiple areas of the brain.
Some neurological diseases, like Parkinson's disease, cause abnormalities in the brain networks.
Deep brain stimulation is a treatment that is used to treat these types of neurological diseases.
Through this research, the investigators will take advantage of the unique opportunity provided by awake deep brain stimulation surgery to learn more about how the brain functions in a diseased state and how deep brain stimulation changes these networks.
This study aims to enroll up to 75 subjects over a period of 2.5 years.
Those who participate in the study will spend up to 40 minutes during their deep brain stimulation surgery during which researchers will record signals from deep structures within the brain as well as the surface of the brain using electrodes that are temporarily placed for research purposes.
During the study, researchers will record signals while subjects perform three different tasks, in some cases while the brain is stimulated.
Study participation is limited to the intraoperative environment with no additional study visits required.
Study Overview
Status
Completed
Intervention / Treatment
Study Type
Observational
Enrollment (Actual)
27
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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California
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Los Angeles, California, United States, 90095
- Nader Pouratian
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
Subjects are patients who are undergoing deep brain stimulation implantation for treatment of Parkinson's disease based on clinical indications as determined by a multidisciplinary neurology-neurosurgery team at each center.
Description
Inclusion Criteria:
- Age > 18
- Rigid-akinetic subtype of Parkinson's disease, diagnosed by a movement disorders neurologist
- Clinical indications, as deemed by a multidisciplinary team of neurologists and neurosurgeons, for deep brain stimulation surgery, including motor fluctuations, difficult-to-control-dyskinesias, unpredictable off-times, and/or dystonia
- Preoperative MRI without cortical or subdural adhesions or vascular abnormalities
- Subject is medically fit for surgical intervention, as deemed by a primary care physician
Exclusion Criteria:
- Inability or unwillingness to tolerate 20 minutes and up to 40 minutes of additional operative time
- Patient with history of secondary Parkinsonism, stroke, or progressive central nervous system disease other than Parkinson's disease.
- Subject is at high risk for surgical complications such as active systemic infection, coagulation disorders (such as the use of anti-thrombotic therapies) or platelet count below 100,000.
- Subject is taking chronic anticoagulants or antiplatelet agent or subject has an abnormally elevated preoperative coagulation profile (either (Partial Thromboplastin Time) PTT or prothrombin time/INR).
- Patients with recent use (within one week) of anticoagulant or antiplatelet agent use
- Subject has history of bleeding or immune compromise.
- Subject has history of implant-related infection.
- Subject has a prior history of seizures or epilepsy.
- Subject has a clinically significant or unstable medical condition including uncontrolled systemic hypertension with values above 170/100; cardiac or pulmonary disease; uncorrected coagulation abnormalities; diabetes; or any condition that would render the patient unable to safely cooperate with the study tests as judged by the screening physician.
- Subject has a significant abnormality on preoperative brain MRI
- Subject has had prior craniotomy or brain surgery.
- Subject has significant memory impairment (based on Montreal Cognitive Assessment (MoCA) < 23).
Subject has a disease or condition that prevents understanding or communication of informed consent, study demands, and testing protocols, including:
- Cognitive decline including diagnosed forms of dementia and/or progressive neurologic disease
- Does not speak a principal language associated with the region
- Hearing loss that prevents adequate communication with researchers.
- Subject has moderate or severe depression (HAMD ≥ 17)
- Subject is implanted with any neuromodulation device in the head including, but not limited to cochlear implant, deep brain stimulator, or auditory brain implant.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Parkinson's Disease
|
If patients participate in this study, after the deep brain stimulator leads have been implanted, the researcher(s) will plan to measure electrical signals from the brain while patients perform hand movement tasks.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Differences in neural signals related to stopping and conflicting movements
Time Frame: Up to 40 minutes
|
Patients will be asked to perform hand movements in response to either a go signals, a conflict signal, or a stopping signal.
|
Up to 40 minutes
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
December 6, 2016
Primary Completion (ACTUAL)
November 10, 2020
Study Completion (ACTUAL)
November 10, 2020
Study Registration Dates
First Submitted
July 24, 2018
First Submitted That Met QC Criteria
July 24, 2018
First Posted (ACTUAL)
July 31, 2018
Study Record Updates
Last Update Posted (ACTUAL)
October 7, 2021
Last Update Submitted That Met QC Criteria
September 29, 2021
Last Verified
September 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 16-001516
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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