- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03684876
Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery (DECONGEST)
May 16, 2023 updated by: Centre Hospitalier Universitaire, Amiens
Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery: a Prospective Observational Study
Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow.
The investigator's standard care includes use of diuretic to avoid interstitial fluid accumulation.
The aim of the study is to assess cardiac and renal function before and after depletion by using diuretics
Study Overview
Detailed Description
The study will compare cardiac and renal data before and 6 hours after use of diuretic
- Echocardiographic measure of right function (S wave, TAPSE, ventricle surfaces, inferior vena cava diameter) and left function (LVEF, cardiac output
- Renal function: cumulative diuresis, creatinine level variation and incidence of acute kidney injury using KDIGO classification (creatinine level>26.5 or diuresis<0.05 ml kg-1 h-1)
Study Type
Observational
Enrollment (Anticipated)
40
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Osama ABOU ARAB, MD
- Phone Number: 87836 33 3 22 08 78 36
- Email: AbouArab.Osama@chu-amiens.fr
Study Locations
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-
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Amiens, France
- Recruiting
- CHU Amiens Picardie
-
Contact:
- Osama ABOU ARAB
- Email: abouarab.osama@chu-amiens.fr
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Sampling Method
Probability Sample
Study Population
patient age >=18 years
Description
Inclusion Criteria:
patient undergoing elective cardiac surgery under cardiopulmonary bypass
Exclusion Criteria:
- heart transplantation
- use of vasopressor
- chronic renal disease (DGF under 30 ml min-1)
- endocarditis
- patient under ECLS or CPIA
- patient under 18-year-old
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
change in renal glomerular filtration before and 6 hours after use of diurectic
Time Frame: at baseline (o hours) and 6 hours after use of diuretic
|
change in renal glomerular filtration before and 6 hours after use of diurectic
|
at baseline (o hours) and 6 hours after use of diuretic
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
June 1, 2018
Primary Completion (Anticipated)
June 1, 2024
Study Completion (Anticipated)
June 1, 2024
Study Registration Dates
First Submitted
July 5, 2018
First Submitted That Met QC Criteria
September 25, 2018
First Posted (Actual)
September 26, 2018
Study Record Updates
Last Update Posted (Actual)
May 17, 2023
Last Update Submitted That Met QC Criteria
May 16, 2023
Last Verified
May 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- PI 2018_843_012
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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