Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery

Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery: a Prospective Observational Study

Sponsors

Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Source Centre Hospitalier Universitaire, Amiens
Brief Summary

Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow. The investigator's standard care includes use of diuretic to avoid interstitial fluid accumulation. The aim of the study is to assess cardiac and renal function before and after depletion by using diuretics

Detailed Description

The study will compare cardiac and renal data before and 6 hours after use of diuretic

- Echocardiographic measure of right function (S wave, TAPSE, ventricle surfaces, inferior vena cava diameter) and left function (LVEF, cardiac output

- Renal function: cumulative diuresis, creatinine level variation and incidence of acute kidney injury using KDIGO classification (creatinine level>26.5 or diuresis<0.05 ml kg-1 h-1)

Overall Status Unknown status
Start Date June 1, 2018
Completion Date June 1, 2020
Primary Completion Date June 1, 2020
Study Type Observational
Primary Outcome
Measure Time Frame
change in renal glomerular filtration before and 6 hours after use of diurectic at baseline (o hours) and 6 hours after use of diuretic
Enrollment 40
Condition
Intervention

Intervention Type: Procedure

Intervention Name: diuretic use

Description: use of diuretic

Eligibility

Sampling Method: Probability Sample

Criteria:

Inclusion Criteria:

patient undergoing elective cardiac surgery under cardiopulmonary bypass

Exclusion Criteria:

- heart transplantation

- use of vasopressor

- chronic renal disease (DGF under 30 ml min-1)

- endocarditis

- patient under ECLS or CPIA

- patient under 18-year-old

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Overall Contact

Last Name: Osama ABOU ARAB, MD

Phone: 33 3 22 08 78 36

Phone Ext.: 87836

Email: [email protected]

Location
Facility: Status: Contact: CHU Amiens Picardie Osama ABOU ARAB [email protected]
Location Countries

France

Verification Date

September 2018

Responsible Party

Type: Sponsor

Keywords
Has Expanded Access No
Condition Browse
Acronym DECONGEST
Patient Data No
Study Design Info

Observational Model: Cohort

Time Perspective: Prospective

Source: ClinicalTrials.gov