- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03733041
Neuromodulation for Exercise Adherence
Neuromodulation for Exercise Adherence in Older Veterans
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Background: Fall-related hospitalizations and consequent morbidity and mortality continue to rise despite the availability for over two decades of evidence-based fall-prevention programs. This is a major problem since more than 2.5 million older adults are treated annually for fall-related injuries in the US. Fall-prevention programs focusing on strength and balance exercises have been successful in facility settings but exercise programs are ineffective at home due to lack of adherence. Estimates indicate that only 1 in 5 individuals adhere to home exercise programs for fall prevention. Thus, there is an urgent need to improve adherence to exercise performed at home by older adults seeking to improve balance for the sake of fall prevention. Behavioral interventions have failed to consistently improve adherence to exercise. Biological reasons for poor exercise adherence, such as executive dysfunction, have not been explored. Adherence to long-term exercise is dependent on executive function (EF), which is controlled by the [dorsolateral prefrontal cortex (DLPFC)] of the brain. EF influences choices in scheduling, forgoing competing activities, enduring subtle costs of time and inconvenience, and the ability to delay gratification. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation increasingly used for neural network specific interventions. rTMS of the DLPFC improves EF, memory, motivation, and mental flexibility. rTMS studies to date have stimulated the motor cortex for gait and balance improvements. The role of DLPFC in exercise adherence has not been explored. The proposed study will be the first to test DLPFC stimulation for improving exercise adherence.
Objective: The study objective is to determine the effects of rTMS treatment of the dorsolateral prefrontal cortex compared to sham on: [1. Short-term (2-wk) changes in executive function;] 2. Long-term (24-wk) adherence to a home-based exercise program; 3. Long-term (24-wk) changes in balance and gait; and [4. Short-term (2-wk) changes in self-efficacy and delay discounting.]
Methods: Sedentary community-dwelling older Veterans (age 65 years, [N=106]) will participate in a double-blind randomized sham-controlled three-phase study. The proposed study will use Nintendo Wii-Fit exercises. Phase I will include two weeks of facility-based exercise for safety assessment and learning the program, followed by 12 weeks of home-based exercises. [Subjects with poor adherence and those with good adherence with low EF] will then be randomized to rTMS or sham treatments. Phase II will include ten consecutive weekdays of rTMS or sham treatment along with exercise training for subjects with poor adherence [and for those with good adherence and low EF] and continuation of home-based exercises for those with good adherence and EF. Phase III includes 24-weeks of a home-based exercise program. All subjects will exercise for 45 minutes five days/week. [Objective measure of adherence collected from Wii-Fit console and Conner's continuous performance test for EF will be the primary outcome measures.] Balance and gait will be assessed. [Self-efficacy, delay discounting along with fear of falls, and falls incidence will be assessed. Outcome measures will be assessed at baseline, and at 14, 16, and 40 weeks.]
Significance: This project will have a major impact in improving adherence to an exercise program and in turn, improve balance in sedentary community-dwelling older Veterans. At the end of the proposed project, the investigators will gain knowledge about the efficacy of rTMS in improving EF and exercise adherence. Knowledge gained about the adherence to home-based exercises would be applicable to multiple conditions such as diabetes. Since Wii-Fit and rTMS are readily available, translation of the study results to clinical practice would be expeditious.
Study Type
Enrollment (Estimated)
Phase
- Phase 4
Contacts and Locations
Study Contact
- Name: Kalpana P Padala, MD MS
- Phone Number: (501) 257-2044
- Email: kalpana.padala@va.gov
Study Locations
-
-
Arkansas
-
North Little Rock, Arkansas, United States, 72114-1706
- Recruiting
- Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR
-
Contact:
- Kalpana P Padala, MD MS
- Phone Number: 501-257-2044
- Email: kalpana.padala@va.gov
-
Principal Investigator:
- Kalpana P Padala, MD MS
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Sedentary Community Dwelling Veterans age 60 years
- Have TV at home
Subjects reporting spending long periods of time in sedentary behavior by answering affirmatively to the question: 'For most days, do you feel you sit for too long (6-8 hours or more a day)?
- Some examples might include when watching TV, working at the computer / laptop or when doing sitting-based hobbies such as reading and sewing' will be included
Exclusion Criteria:
GENERAL EXCLUSION CRITERIA
- Those that participate in regular physical activity for at least 30 minutes five or more days of the week
EXCLUSIONARY DUE TO Wii-Fit Exercises
- Use of wheel chair for mobility
- Cognitive impairment [Montreal Cognitive Assessment (MoCA < 26)]
- Weight 325 lbs. (weight restriction of the Wii-Board)
- Absolute contraindications to exercise per The American College of Sports Medicine guidelines
- Those with medical conditions that in the opinion of the study physician are likely to compromise safe participation
EXCLUSIONARY DUE TO rTMS
- Taking medications known to increase risk of seizures from 2012 Beers criteria such as bupropion, chlorpromazine, clozapine.
- Taking other medications known to increase risk of seizures such as tricyclic antidepressants.
- Taking ototoxic medications: Aminoglycosides, CisplatinHistory of seizures/ seizures in first degree relatives
- Those with implanted device
- History of stroke, aneurysm, or cranial neurosurgery
- History of bipolar disorder
- History of abnormal electroencephalogram (EEG)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Sham Comparator: Sham
This group will be randomized to receive sham treatment
|
This group will receive sham treatment
|
Active Comparator: rTMS
This group will be randomized to receive rTMS
|
This group will receive rTMS treatment
|
Other: No intervention
This group will receive no intervention
|
This group will receive no intervention
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Adherence as measured by number of minutes
Time Frame: 14 weeks, 40 weeks
|
Total number of minutes exercised
|
14 weeks, 40 weeks
|
Change in Conner's Continuous Performance Test
Time Frame: 14 weeks, 16 weeks, 40 weeks
|
Commission Error percentage Range 0-100% Higher score is improvement
|
14 weeks, 16 weeks, 40 weeks
|
Change in Adherence as measured by number of sessions
Time Frame: 14 weeks, 40 weeks
|
Total number of sessions exercised
|
14 weeks, 40 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Gait speed
Time Frame: 14 weeks, 16 weeks, 40 weeks
|
The test measures habitual walking speed in meters/sec
|
14 weeks, 16 weeks, 40 weeks
|
Change in Timed Up and Go
Time Frame: 14 weeks, 16 weeks, 40 weeks
|
This is a widely accepted test of pro-active balance and mobility and measured in secs
|
14 weeks, 16 weeks, 40 weeks
|
Collaborators and Investigators
Investigators
- Principal Investigator: Kalpana P Padala, MD MS, Central Arkansas Veterans Healthcare System Eugene J. Towbin Healthcare Center, Little Rock, AR
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- E2961-R
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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