- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03737539
Dynamic Monitoring of ctDNA Methylation to Predict Relapse in Colorectal Cancer After Radical Resection (POSTCA)
May 17, 2023 updated by: Guoxiang Cai, Fudan University
Dynamic Monitoring of Circulating Tumor DNA Methylation to Predict Relapse in Colorectal Cancer After Radical Resection: A Prospective, Multicenter, Clinical Study (POSTCA)
This is a prospective, multicenter, observational, single-blinded controlled study.
Dynamic monitoring of patients with resectable colorectal cancer was performed using the previously established colorectal tumor-specific plasma ctDNA methylation markers (Multigene methylation detection).
Dynamic monitoring of plasma ctDNA methylation before and after treatment and at regular follow-up in patients with colorectal cancer after radical resection of tumor, to explore the predictive effect of postoperative plasma ctDNA methylation on postoperative recurrence and whether dynamic monitoring of postoperative ctDNA methylation could be earlier than imaging examination to indicate tumor recurrence.
Study Overview
Status
Recruiting
Intervention / Treatment
Detailed Description
At present, the main treatment of colorectal cancer (CRC) is surgical resection.
CRC patients after radical surgery have good overall survival.
However, there are still a large number of patients with postoperative recurrence.
The postoperative recurrence rate of stage II CRC patients is 20-30%, and that of stage III CRC patients is 50-60%.
Currently, there is no effective measures to predict whether patients suffer postoperative relapse.
Patients can only periodically visit doctors in the hope of timely treatment in case of recurrence.
Current clinical monitoring methods mainly include imaging detection and tumor markers detection.
However, long-term monitoring may affect patients' quality of life and increase patients' economic burden.
Therefore, biomarkers that can predict the prognosis of patients and screen out those who need intensive follow up are urgently warranted.
At present, imaging is the mainly used approach to monitor tumor recurrence.
Quantitative determination of ctDNA methylation in plasma may find tumor recurrence trend before imaging detection, indicating that quantitative determination of ctDNA methylation in plasma is a more sensitive monitoring approach than traditional imaging detection.
Can plasma ctDNA methylation be a new recurrence monitoring technique and prognostic prediction method of CRC in clinical practice?
In this study, we aimed to monitor the dynamic level of plasma ctDNA methylation after surgery in CRC patients, and to explore the advantages of plasma ctDNA methylation detection over traditional CRC in recurrence monitoring and prognosis prediction.
This is a prospective, multicenter, observational, single-blinded controlled study.
Dynamic monitoring of CRC patients was performed using the previously established colorectal tumor-specific plasma ctDNA methylation markers.
Dynamic monitoring of plasma ctDNA methylation before and after treatment and at regular follow-up in patients with CRC after radical resection of tumor, to explore the predictive effect of postoperative plasma ctDNA methylation on postoperative recurrence and whether dynamic monitoring of postoperative ctDNA methylation could be earlier than imaging examination to indicate tumor recurrence.
Study Type
Observational
Enrollment (Anticipated)
300
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Guoxiang Cai, M.D. Ph.D.
- Phone Number: +86 13611831623
- Email: gxcai@fudan.edu.cn
Study Locations
-
-
-
Shanghai, China, 200032
- Recruiting
- Fudan University Shanghai Cancer Center
-
Contact:
- Guoxiang Cai, M.D. Ph.D.
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Sampling Method
Non-Probability Sample
Study Population
Patients with resectable colorectal cancer must have baseline evaluations performed prior to the study and must meet all inclusion and exclusion criteria.
In addition, the patient must be thoroughly informed about all aspects of the study, including the study visit schedule and required evaluations and all regulatory requirements for informed consent.
Description
Inclusion Criteria:
- Male or female ≥ 18 years of age on the day of signing informed consent.
- Patients must have histologically confirmed colorectal cancer.
- Patients need to receive surgical resection.
- Patients must have a performance status of ≤1 on the ECOG Performance Scale.
- Life expectancy of more than 5 years.
- Written informed consent must be obtained from patient or patient's legal representative and ability for patient to comply with the requirements of the study.
Exclusion Criteria:
- Patients received adjuvant treatment prior to the surgical resection.
- Patients received blood transfusion two weeks before or during the surgical resection.
- Patients with unresected advanced colorectal adenoma.
- Patients who are positive for Human Immunodeficiency Virus (HIV), Hepatitis B or Hepatitis C.
- Patients who are pregnant.
- Patients who are alcoholic or drug abusers.
- Patients with a history or current evidence of any condition or abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the Investigator.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Colorectal cancer
Patients diagnosed with resectable colorectal cancer
|
Colorectal tumor-specific plasma ctDNA methylation markers detection
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Disease Free Survival (DFS)
Time Frame: 2-year DFS
|
The primary endpoint for this study is Disease Free Survival (DFS), which will be assessed using RECIST version 1.1.
|
2-year DFS
|
ctDNA methylation markers versus CT/MRI
Time Frame: 2 years
|
ctDNA methylation predictors of outcome will be compared to CT/MRI
|
2 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
September 1, 2018
Primary Completion (Anticipated)
June 1, 2023
Study Completion (Anticipated)
June 1, 2024
Study Registration Dates
First Submitted
November 8, 2018
First Submitted That Met QC Criteria
November 8, 2018
First Posted (Actual)
November 9, 2018
Study Record Updates
Last Update Posted (Actual)
May 19, 2023
Last Update Submitted That Met QC Criteria
May 17, 2023
Last Verified
May 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- FDCRC42-CGX (POSTCA trial)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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