Brain and Genetic Predictors of Individual Differences in Pain and Analgesia (PAINGEN)

The purpose of the study is to gain a better understanding of pain processing in the brain. Our understanding of how pain is processed in the brain is limited. We are testing for individual differences in pain perception and emotion.

Study Overview

• Status: Completed
• Conditions: Pain, Acute

• Study Type: Observational
• Enrollment (Actual): 545

Contacts and Locations

Study Locations

• United States
  • Colorado
    • Boulder, Colorado, United States, 80309
      • University of Colorado, Boulder

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 55 years (Adult)
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

The CTS includes 727 same-sex twin pairs between 26-38 years old (as of Spring 2017), originally derived from the Colorado Twin Registry, a population based registry, housed at the Institute for Behavioral Genetics (IBG) at the University of Colorado since 1984, with three previous waves of data collection (1997-2002, 2002-2008, and 2009-2014).

Description

Inclusion Criteria:

• Participants must be registered in the Colorado Community Twin Sample (CTS).

Exclusion Criteria:

• Not being registered in the Colorado Community Twin Sample (CTS).
• Any MRI contraindications.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in pain rating scores made on a Visual Analog Scale (VAS)	Self reported pain using the VAS ranging from 0-100 (with 0 representing "no pain at all" and 100 representing "most intense pain imaginable (in the context of the experiment)).	Measured during pain tasks at a single 4 hour experimental session (within one month of screening completion).

Collaborators and Investigators

• Sponsor: Trustees of Dartmouth College
• Collaborators: QIMR Berghofer Medical Research Institute
• Investigators: Principal Investigator: Tor Wager, PHD, University of Colorado, Boulder

Study record dates

Study Major Dates

• Study Start (Actual): November 7, 2018
• Primary Completion (Actual): October 1, 2023
• Study Completion (Actual): October 1, 2023

Study Registration Dates

• First Submitted: December 14, 2018
• First Submitted That Met QC Criteria: December 17, 2018
• First Posted (Actual): December 20, 2018

Study Record Updates

• Last Update Posted (Actual): November 27, 2023
• Last Update Submitted That Met QC Criteria: November 21, 2023
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pain; Neurologic Manifestations; Acute Pain
• Other Study ID Numbers: Pain Genetics

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No