High Intensity Interval Circuit Training on Resting Metabolic Rate in Overweight Adults

The Effect of High Intensity Interval Circuit Training With Portable Equipment on Changes in Resting Metabolic Rate in Overweight Adults

This is the first study to examine changes in resting metabolic rate up to 72 hours following an exercise session, and how these changes may be affected by 12 weeks of high intensity interval circuit training (HIICT). Various training programs that have been implemented in previous studies have investigated changes in resting metabolic rate only for the first 2-8 hours following an exercise session.

Briefly, the results of this study will provide insight into the following:

1. To what extent and for how long does HIICT increases the resting metabolic rate following an exercise session?
2. How can this exercise program enhance metabolism without any dietary or other exercise intervention?
3. What is the caloric deficit that will result from 3 months of HIICT and how to what extent this deficit will influence body weight reduction?

Study Overview

• Status: Completed
• Conditions: Overweight and Obesity
• Intervention / Treatment: Other: Exercise training - Phase 1; Other: Exercise training - Phase 2; Other: Exercise training - Phase 3

Detailed Description

According to the World Health Organization, overweight and obesity are defined as as abnormal or excessive fat accumulation, that presents a risk to health. Body Mass Index (BMI) is a useful population-level measure of overweight and obesity in adults, defined as follows: BMI = [weight (kg)] / [height (m)^2]. Individuals with BMI>25 kg/m^2 are considered overweight, whereas individuals with BMI>30 are considered obese. The higher the BMI, the greater the risk of developing non-communicable diseases, such as cardiovascular disease, diabetes mellitus and various forms of cancer. Obesity is now the most widespread disease in the developed world. It has been estimated that over 1.9 billion adults (39% of the population) are overweight, of whom 600 million (13% of the population) are obese. These rates are translated into a significant economic impact on a county's health care system; therefore, drastic measures are needed. The major cause of obesity is an energy imbalance between caloric intake and energy expenditure in favor of the former. Thus, changes in lifestyle that affect the energy balance, such as participation in an exercise program, can reduce body weight and, therefore, contribute to obesity treatment.

The recommendation of physical activity for significant weight loss involves prolonged exercise of moderate to high intensity that gradually increases to ~250 minutes/week. Resistance training is also recommended as it activates the neuromuscular system and can improve functional ability. On the other hand, High Intensity Interval Training (HIIT), which mainly involves a cardiovascular exercise strategy alternating short periods of intense anaerobic exercise with less intense recovery periods, are proposed because they are time-efficient. In addition, HIIT improves aerobic capacity and body composition, which is related to resting metabolic rate and mitochondrial metabolism of skeletal muscle in both healthy and overweight and obese adults. Changes caused by HIIT in mitochondrial function may explain the greater efficacy in inducing positive metabolic adaptations compared to traditional endurance or resistance protocols, even when not accompanied by dietary weight loss strategies.

Resting metabolic rate is defined as the energy expenditure required to maintain the normal physiological processes of the body at rest and accounts for 60-75% of the total daily energy expenditure. Small increases in resting metabolic rate could long-term positive effects on weight management. Energy expenditure is increased not only during exercise, but also for some hours post-exercise. To date, it has been observed that this increase in resting metabolic rate can last for up to 48 hours following an exercise session, especially following resistance training. More specifically, in a study where 7 women (22-35 years old) participated in a resistance training program (100 minutes/session, 10 exercises of 5 sets with 10-15 repetitions per set), there was an increase in their resting metabolic rate by 13% at the first 3 hours and an increase by 4.2% at 16 hours following an exercise session. On the other hand, a 10-week (3 session/week) strength training program with an intensity of 65-85% of the maximum heart rate based on age (gradual increase in intensity), did not appear to cause any changes in resting metabolic rate following an exercise session. However, in another study where resistance training (strength protocol of 3 sets with 10-15 repetitions per set at the beginning of intervention up to 4-8 repetitions at the end of the intervention) was combined with endurance training (65% to 85% with an intensity of 65-85% of the maximum heart rate based on age, of increasing intensity), it was observed that resting metabolic rate increased following an exercise session.

It is important to note that, according to the available literature, it has been shown that training studies have been examined changes in resting metabolic rate only up to 2-8 hours following an exercise session. Therefore, the aim of the present study is to investigate the effect of a 12-week HIICT protocol with portable equipment on changes in resting metabolic rate 24, 48 and 72 hours following an exercise session.

Flow of the research design:

1. Baseline: Anthropometric and physiological measurements (including a Resting Metabolic Rate (RMR) measurement following an overnight fast).
2. One-week familiarization period: Volunteers will participate in two exercise sessions in order to learn the right techniques. RMR will be measured 24, 48 and 72 hours following the last exercise session. Moreover, participants will be given instructions and then they will record their diet for 3 days (2 week days and one weekend day).
3. Initiation of the 12-week HIICT program: The program will be supervised and portable training equipment will be used. There will be 3 exercise sessions per week (Monday-Wednesday-Friday). The program will be divided into 3 phases (4 weeks each phase), where exercise intensity will increase gradually.
4. 1st phase: RMR will be measured 24 hours before, as well as 24, 48 and 72 hours following the last exercise session of the phase (e.g. at the end of the 4th week of the program). Anthropometric and physiological measurements will also be conducted. Moreover, participants will record their diet for 3 days (2 week days and one weekend day).
5. 2nd phase: Exercise intensity will increase. The same measurements with phase 1 will be conducted.
6. 3rd phase: Exercise intensity will increase. The same measurements with phases 1 and 2 will be conducted.

• Study Type: Interventional
• Enrollment (Actual): 20
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Greece
  • Trikala, Greece, 42100
    • SmArT LABORATORY, SCHOOL OF PHYSICAL EDUCATION & SPORTS SCIENCES, UNIVERSITY OF THESSALY

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 30 years to 50 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Overweight or class I obesity (BMI: 25-35 kg/m^2)
• Sedentary lifestyle
• Willing to lose weight
• Individuals at low risk of various cardiovascular, pulmonary, renal, and metabolic diseases as well as other conditions (e.g., pregnancy and orthopedic injury) that require special attention when developing the exercise prescription (Thompson et al., 2013). This risk classification indicates that participants will be able to participate in moderate intensity exercise [40-60% oxygen uptake reserve (VO2R); 3-6 metabolic equivalent of task (METs)] and also in vigorous intensity exercise (>60% VO2R; >6 METs) while medical examination, exercise test and physician supervision are not recommended in the preparticipation health screening process.

Exclusion Criteria:

• Following a diet plan or taking dietary supplements over the last 6 months and during the intervention
• Participation in another training program over the last 6 months and during the intervention
• Family history of coronary heart disease
• Recent musculoskeletal injury

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Experimental group; A 12-week high intensity interval circuit training program for weight management in overweight adults.	Other: Exercise training - Phase 1; Phase 1 is the first 4 weeks of the 12-week training program.; Other: Exercise training - Phase 2; Phase 2 is the next 4 weeks following phase 1 of the 12-week training program. The exercise intensity during exercise bouts in this phase is increased compared to the exercise intensity applied in phase 1.; Other: Exercise training - Phase 3; Phase 3 is the last 4 weeks of the 12-week training program. The exercise intensity during exercise bouts in this phase is increased compared to the exercise intensity applied in the previous phases.
No Intervention: Control group; No intervention for 12 weeks, participants perform all tests.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Resting metabolic rate (kilocalories)	Resting metabolic rate following 12 hours of an overnight fast	At baseline
Resting metabolic rate (24 before an exercise bout) (kilocalories)	Changes in resting metabolic rate 24 before an exercise bout	Pre-intervention, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3
Resting metabolic rate (24 following an exercise bout) (kilocalories)	Changes in resting metabolic rate 24 following an exercise bout	Pre-intervention, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3
Resting metabolic rate (48 following an exercise bout) (kilocalories)	Changes in resting metabolic rate 48 following an exercise bout	Pre-intervention, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3
Resting metabolic rate (72 following an exercise bout) (kilocalories)	Changes in resting metabolic rate 72 following an exercise bout	Pre-intervention, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3
Body fat mass (kilograms)	Changes in body fat mass measured with dual-energy x-ray absorptiometry (DEXA)	At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3
Body lean mass (kilograms)	Changes in body lean mass measured with dual-energy x-ray absorptiometry (DEXA)	At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3
Bone mass (kilograms)	Changes in bone mass measured with dual-energy x-ray absorptiometry (DEXA)	At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Waist to hip ratio (WHR)	WHR is calculated by dividing waist circumference by hip circumference	At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3
Lower limb strength	Leg press (10 Repetition Maximum - RM)	At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3
Upper body strength	Chest press (10 Repetition Maximum - RM)	At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3
Aerobic capacity test	Ebbeling submaximal treadmill walking test	At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3
Maximal abdominal muscle endurance	Maximal repetition till exhaustion	At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

Collaborators and Investigators

• Sponsor: University of Thessaly
• Investigators: Study Director: Ioannis G Fatouros, PhD, SmArT Lab, DPESS, University of Thessaly

Study record dates

Study Major Dates

• Study Start (Actual): April 8, 2019
• Primary Completion (Actual): July 20, 2019
• Study Completion (Actual): August 20, 2019

Study Registration Dates

• First Submitted: May 23, 2019
• First Submitted That Met QC Criteria: May 30, 2019
• First Posted (Actual): June 3, 2019

Study Record Updates

• Last Update Posted (Actual): November 6, 2019
• Last Update Submitted That Met QC Criteria: November 4, 2019
• Last Verified: November 1, 2019

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Body Weight; Overweight
• Other Study ID Numbers: HIICT-RMR study

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No