- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04013958
Comparison of Treatment by IM Ketamine to IV Ketamine in Patients With Renal Colic
Patients who present to the emergency department (ED), with acute pain due to renal colic, are often treated with opioids. Treatment with opioids has many disadvantages - cardio-respiratory depression, nausea, vomiting and long term dependence. For these reasons, there is a constant search for a way to reduce the use of opioids. ketamine has been proven to augmented the analgesic effect of opioids, and thus reduce the use and adverse effects of opioids. Different studies about the use of Ketamine as a sedition agent have shown that Ketamine given IM versus IV has longer duration of effect with less adverse effects.
The study we are conducting is designed to test and analyze the safety and efficacy of IV Ketamine with IV Morphine compared to IV Ketamine and morphine with IM placebo in a setting of acute pain due to, or suspected renal colic in the ED. When both ways of administration are given by the protocol as is customary for treatment of pain in the Emergency Medicine department, and will be a prospective, randomized, double blind, controlled study.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The procedure:
- Eligible patients will be identified by the ED personnel.
- Research physician will address the patient, explain about the trial and ask the patient to sign a consent form.
- The patient will be randomized and assigned to a trial group: "A" or "B" and it will be noted in the Data sheet.
- According to physician order (IV amount and IM amount) and patient group assignment, the nurse will prepare and administer the different drugs.
- Patients in group "A" wiil receive IV Ketamine with IV morphine and IM placebo of normal saline. Patients in group "B" wiil receive IM Ketamine with IV morphine.
The amount will be calculated based on the patients' weight:
IV Morphine -0.1 mg/kg: Morphine vial contains 10 mg/10 ml. IV Ketamine -0.1 mg/kg: Ketamine vial contains 50 mg/1 ml. IM Ketamine -0.25 mg/kg: Ketamine vial contains 50 mg/1 ml.
- Prior to administering medication to the patient a research assistant, who is blinded to the choice of drugs given, will measure vital signs (blood pressure, heart rate and O2 saturation) as well as pain level on a 100 mm VAS (visual analogue scale) questionnaire.
- After administration of medications the researcher assistant will measure vital signs (blood pressure, heart rate and O2 saturation) as well as pain level on a 100 mm VAS questionnaire, at 5 and 10 minutes after administration, and then at 30, 45, 60, and 90 minutes.
- Measurement of vital signs will not interfere with any other treatment that the patients receives for their injury in the ED.
- Cardiorespiratory follow-up (as per bullet point number 8 above), will be concluded at 1.5 hours post-intervention, and clinical follow-up will continue as long as the patient remains in the ED.
- During the time of the the followup and after, if pain had not subsided sufficiently according to treating physician's clinical assessment, patient will receive further analgesic medications by physician order, as per ED protocol. The protocol takes into account concurrent medications.
Study Type
Enrollment (Anticipated)
Phase
- Phase 3
Contacts and Locations
Study Contact
- Name: Daniel Trotzky, MD
- Phone Number: +97236973829
- Email: danieltro@tlvmc.gov.il
Study Contact Backup
- Name: Omri Ritter, MD
- Phone Number: +972508683149
- Email: omrir@tlvmc.gov.il
Study Locations
-
-
-
Tel-Aviv, Israel, 6423906
- Tel Aviv Sourasky Medical Center, department of Emergency Medicine
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Age 18-70
- Self-report pain greater than or equal to 7/10 on a numerical-verbal scale
- Weigh 50-100 kg
- Have systolic blood pressure of 90-180 mmHg
- Have an ASA (American Society of Anaesthesiologists' classification) score of 1-2
Exclusion Criteria:
- Have had opioid analgesia administered within 6 hours of the study
- Are chronic analgesia users (of opioid or others)
- Have known allergies to morphine or ketamine
- Are pregnant
- Have a psychiatric history
Study Plan
How is the study designed?
Design Details
- Primary Purpose: SUPPORTIVE_CARE
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: TRIPLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
ACTIVE_COMPARATOR: IV Ketamine
IV Ketamine group will receive IV Ketamine with IV morphine and IM saline.
|
IV Ketamine 0.1 mg/kg with IV morphine -0.1 mg/kg with IM Sailne 0.9%
Other Names:
|
EXPERIMENTAL: IM Ketamine
IM Ketamine group will receive IM Ketamine with IV morphine.
|
IM Ketamine 0.3 mg/kg with IV morphine -0.1 mg/kg
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Effectiveness of IM Ketamine in decreasing pain intensity [patient assessed - VAS pain score]
Time Frame: 1.5 hour post administration
|
Time to achieve a clinically meaningful pain reduction was defined as the first time-point at which the patient reported 15mm of pain reduction or more.
Maximal pain reduction was defined as the lowest VAS score reported by the patient over the course of follow-up.
Time to maximal pain reduction was defined as the time at which the patient has the lowest VAS score over the course of the 1.5 hours follow-up.
|
1.5 hour post administration
|
Adverse effects [Opiate Related Symptom Distress Scale]
Time Frame: 1.5 hour post administration
|
adverse effects [Opiate Related Symptom Distress Scale] [ Time Frame: 1.5 hour post administration ]
|
1.5 hour post administration
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (ANTICIPATED)
Primary Completion (ANTICIPATED)
Study Completion (ANTICIPATED)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Pain
- Neurologic Manifestations
- Infant, Newborn, Diseases
- Renal Colic
- Colic
- Acute Pain
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Central Nervous System Depressants
- Peripheral Nervous System Agents
- Analgesics
- Sensory System Agents
- Anesthetics, Dissociative
- Anesthetics, Intravenous
- Anesthetics, General
- Anesthetics
- Excitatory Amino Acid Antagonists
- Excitatory Amino Acid Agents
- Ketamine
Other Study ID Numbers
- TASMC-19-DT-0060-19-CTIL
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Renal Colic
-
Lampang HospitalCompleted
-
Oman Medical Speciality BoardCompletedAcute Renal ColicOman
-
Centre Hospitalier Universitaire de NīmesWithdrawnIntravenous Paracetamol Versus Ketoprofen When Treating Renal Colic in Emergency Situations (PIVKIV)Renal Colic | Acute Renal ColicFrance
-
University of MonastirRecruiting
-
Ataturk UniversityCompleted
-
Lille Catholic UniversityUnknown
-
Tehran University of Medical SciencesCompletedPain | Renal ColicIran, Islamic Republic of
-
Seoul National University HospitalCompleted
Clinical Trials on IV Ketamine
-
Children's Hospital of MichiganCompletedModerate, Deep Sedation
-
Lawson Health Research InstituteUnknownBone Fractures | Dislocations
-
Alameda Health SystemCompleted
-
Dr. Marie Eve Sophie Bussiere-CoteSuspendedAbortion in First TrimesterCanada
-
Northwestern UniversityActive, not recruitingPain | Postpartum DepressionUnited States
-
Yonsei UniversityWithdrawnLaparoscopic Colorectal Resection Due to CancerKorea, Republic of
-
Icahn School of Medicine at Mount SinaiRecruitingDepression | Mild Cognitive ImpairmentUnited States
-
Janssen Research & Development, LLCCompleted
-
Yale UniversityCompletedMajor Depressive Disorder | Post-Traumatic Stress Disorder (PTSD)United States
-
Ohio State UniversityRecruitingMajor Depressive DisorderUnited States