The Effect of Different Exercise Programs in Coronary Artery Patients: A Randomized Controlled Study

There are studies showing the superiority of HIIT protocols in patients with CAD in the literature, however there is no consensus on the use of HIIT protocols in CAD patients. In addition, in these studies, the HIIT protocols differ in severity and duration and there is no optimal HIIT protocol. Therefore, this study was planed to investigate of two different HIIT protocols and one MICT protocols, which are more commonly used in patients with CAD in the literature on exercise capacity, quality of life, body composition, physical activity level and fear of movement.

Study Overview

• Status: Completed
• Conditions: Exercise; Cardiac Rehabilitation
• Intervention / Treatment: Other: Exercise

• Study Type: Interventional
• Enrollment (Actual): 20
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey
  • Center
    • Kutahya, Center, Turkey, 43100
      • Kütahya Health Sciences University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 30 years to 70 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Have undergone percutaneous transluminal coronary angioplasty or coronary artery bypass graft surgery,
• Nonobstructive CAD registered by angiography
• Left ventricular ejection fraction above 50%,
• Clinically stable for more than 2 weeks in terms of symptoms and medical treatment.

Exclusion Criteria:

• Ischemia symptoms,
• Being in Class III-IV according to the New York Heart Classification,
• Obtaining significant left ventricular outflow obstruction,
• Ventricular arrhythmia,
• Being marked valvular heart disease,
• Failure to comply with exercise testing and training rules,
• To have significant orthopedic or neurological comorbidity that prevents full participation.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Modarete Intensity Continous Training	Other: Exercise; Modarete Intensity Continous Training: Medium intensity continuous exercise training will be performed. Exercise intensity will be adjusted as 50-70% of maximal power. High Intensity Interval Training I: It will be four cycles consisting of 4 minute high intensity exercise phase and 3 minute active recovery phase. High intensity phase will be adjusted as 85-100% of maximal power and active recovery phase as 50-70% of maximal power. High Intensity Interval Training II: It will be 10 cycles consisting of 1 minute high intensity exercise phase and 1 minute active recovery phase. High intensity phase will be adjusted as 85-100% of maximal power and active recovery phase as 50-70% of maximal power.
Experimental: High Intensity Interval Training I	Other: Exercise; Modarete Intensity Continous Training: Medium intensity continuous exercise training will be performed. Exercise intensity will be adjusted as 50-70% of maximal power. High Intensity Interval Training I: It will be four cycles consisting of 4 minute high intensity exercise phase and 3 minute active recovery phase. High intensity phase will be adjusted as 85-100% of maximal power and active recovery phase as 50-70% of maximal power. High Intensity Interval Training II: It will be 10 cycles consisting of 1 minute high intensity exercise phase and 1 minute active recovery phase. High intensity phase will be adjusted as 85-100% of maximal power and active recovery phase as 50-70% of maximal power.
Experimental: High Intensity Interval Training II	Other: Exercise; Modarete Intensity Continous Training: Medium intensity continuous exercise training will be performed. Exercise intensity will be adjusted as 50-70% of maximal power. High Intensity Interval Training I: It will be four cycles consisting of 4 minute high intensity exercise phase and 3 minute active recovery phase. High intensity phase will be adjusted as 85-100% of maximal power and active recovery phase as 50-70% of maximal power. High Intensity Interval Training II: It will be 10 cycles consisting of 1 minute high intensity exercise phase and 1 minute active recovery phase. High intensity phase will be adjusted as 85-100% of maximal power and active recovery phase as 50-70% of maximal power.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
exercise capacity	Cardiopulmonary exercise test	15 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
MacNew Health Related Quallity of Life Qustionnaire	The validity and reliability of the MacNew Heart Disease Health-Related Quality of Life Questionnaire Daşkapan et al. in 2008. It is a scale developed to determine the quality of life in heart diseases consisting of 27 items each containing a 7-point Likert type response. In the evaluation of the scale, 3 sub-dimensions (emotional, physical and social) and total score values are used	15 minutes
body composition	Tanita	1 minute
physical activity level	International Physical Activity Questionnaire	15 minutes
fear of movement	Tampa	15 minutes

Collaborators and Investigators

• Sponsor: Kutahya Health Sciences University

Study record dates

Study Major Dates

• Study Start (Actual): July 15, 2019
• Primary Completion (Actual): March 1, 2021
• Study Completion (Actual): January 1, 2022

Study Registration Dates

• First Submitted: August 5, 2019
• First Submitted That Met QC Criteria: August 5, 2019
• First Posted (Actual): August 7, 2019

Study Record Updates

• Last Update Posted (Actual): August 22, 2022
• Last Update Submitted That Met QC Criteria: August 18, 2022
• Last Verified: August 1, 2022

More Information

Terms related to this study

• Other Study ID Numbers: KMSU-Exercise

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No