- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04095442
Effect of Antibacterial Mouthwash on Muscle Function in Healthy Young Men and Women
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Visit One:
During an initial visit, subjects will complete the informed consent process, be instructed on the requirements of the study, and practice the exercise protocol (see below).
Study Visit Two:
Subjects will be tested after they have avoided exercise, caffeine, alcohol, chewing gum, and foods high in nitrate (e.g., spinach, beets, collard greens) for at least 24 hours. They will also be asked to not use any mouthwash products during this period. They will then provide provide a saliva sample for subsequent measurement of nitrate and nitrite concentrations and have their breath nitric oxide levels measured using a portable analyzer. The maximal knee extensor speed and power of their knee extensor muscles will then be measured using an isokinetic dynamometer. This machine can control the speed of movement while measuring the maximal force (torque) that a subject can voluntarily produce.
Subjects will then be randomly assigned to receive either an antibacterial mouthwash (Cepacol©, Reckitt Benckiser, Parsippany, NJ) or, as a control solution, an alcohol-free "natural" mouthwash (Tom's of Maine©, Kennebunk, ME). Participants will be asked to rinse their mouth as directed on the product's packaging for 30 s twice per day for 7 (+/-2) days and to record the usage of the mouthwash on a provided form. Subjects will then return for Study Visit 3 (see below). This is considered a single-blind study, which means that the investigators will not know what type of mouthwash a subject is receives.
Study Visit Three:
At the end of the treatment period, subjects will be asked to return to undergo the same procedures as described for Study Visit Two.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Indiana
-
Indianapolis, Indiana, United States, 46202
- Indiana University School of Health and Human Sciences
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion:
- Men and Women age 18-30 years old
- No current use of mouthwash
Exclusion:
- Men and Women <18 or 30> y of age
- Unable to provide informed consent
- Current users of mouthwash
- Current antibiotic use
- Current smokers
- Currently pregnant or lactating
- Stage II hypertension (resting blood pressure >140/>90)
An answer of yes to any of the seven questions on the first page of the Physical Activity Readiness Questionnaire (PAR-Q) indicating that the subject is not physically ready for exercise without a medical exam. These exclusions include the following:
- If participant's doctor has ever said that he/she has a heart condition and that he/she should only do physical activity recommended by a doctor
- Pain in chest when doing physical activity
- In past month, chest pain when not doing physical activity
- If participant has ever lost balance because of dizziness or has ever lost consciousness
- Bone or joint problem that could be made worse by change in physical activity
- Currently on prescribed drugs for blood pressure or heart condition.
- If the participant knows of any other reason why he/she should not do physical activity.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Cepacol
|
Twice-daily use of Cepacol per the manufacturer's guidelines
|
Sham Comparator: Tom's Natural Mouthwash
|
Twice-daily use of Tom's Natural Mouthwash per the manufacturer's guidelines
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Muscle Function
Time Frame: 1 day
|
Maximal knee extensor speed determined using isokinetic dynamometry
|
1 day
|
Muscle Function
Time Frame: 7 day
|
Maximal knee extensor speed determined using isokinetic dynamometry
|
7 day
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Salivary Nitrate
Time Frame: 1 day
|
Salivary concentration of nitrate
|
1 day
|
Salivary Nitrite
Time Frame: 7 day
|
Salivary concentration of nitrite
|
7 day
|
Breath Nitric Oxide
Time Frame: 1 day
|
Breath nitric oxide level
|
1 day
|
Breath Nitric Oxide
Time Frame: 7 day
|
Breath nitric oxide level
|
7 day
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1907204336
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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