- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04144686
Advances in Vestibular Rehabilitation
'Effectiveness of Customised Vestibular Rehabilitation With and Without Additional Dual-Task Training in Persons With a Chronic Vestibular Disorder. A Randomised Controlled Trial'
Vestibular rehabilitation therapy (VRT) is an exercise-based programme to encourage central nervous system (CNS) compensation for vestibular dysfunction. There is moderate to strong evidence to support VRT as a safe, effective management in reducing dizziness, vertigo, associated falls and improving quality of life in people with a unilateral and bilateral peripheral vestibular disorder. However, the evidence to discriminate between differing forms of treatment is unclear and, although, approximately 50% to 80% of persons with a vestibular dysfunction achieve significant subjective symptom, gait, dynamic visual acuity and postural stability improvements, full recovery is less common for reasons that currently remain unknown. Thus, further studies are required to identify optimal VRT approaches.
The purpose of this investigation is to identify if the incorporation of dual-task (DT) exercises into a customised VRT programme will have an effect on treatment outcomes in persons with chronic vestibular disorders.
Study Overview
Detailed Description
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Reza Razavi
- Phone Number: 02078483224
- Email: reza.razavi@kcl.ac.uk
Study Contact Backup
- Name: Marousa Pavlou
- Phone Number: 02078486328
- Email: marousa.pavlou@kcl.ac.uk
Study Locations
-
-
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London, United Kingdom, SE1 1UL
- Recruiting
- King's College London
-
Contact:
- Marousa Pavlou
- Phone Number: 02078486328
- Email: marousa.pavlou@kcl.ac.uk
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Contact:
- Viktoria Azoidou
- Phone Number: Azoidou 02078486679
- Email: viktoria.azoidou@kcl.ac.uk
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Sub-Investigator:
- Irene Di Giulio
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Sub-Investigator:
- Louisa Murdin
-
Sub-Investigator:
- Doris Bamiou
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- clinical diagnosis of a peripheral vestibular disorder
- chronic dizziness and/or unsteadiness
- 18 to 80 years' old
- previous vestibular rehabilitation programme completed with partial/no improvement
- willing to participate and to comply with the proposed training and testing regime
Exclusion Criteria:
Persons with
- central nervous system involvement, excluding migraine
- fluctuating symptoms, for example, active Ménière disease
- acute orthopaedic disorders influencing balance control and gait
- a score of < 23/30 on the MoCA
- a score of >15/21 on the HADS for the depression component indicating significant depression symptoms
- inability to attend sessions
- lack of a good grasp of written/spoken English will be excluded.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Group A
Vestibular participants undertaking a single-task vestibular rehabilitation
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Participants will be randomly allocated, using a random number generator, to a 12-week supervised customised exercise group incorporating VRT programme without (Group A) or with cognitive DT exercises (Group B).
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Experimental: Group B
Vestibular participants undertaking a dual-task vestibular rehabilitation
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Participants will be randomly allocated, using a random number generator, to a 12-week supervised customised exercise group incorporating VRT programme without (Group A) or with cognitive DT exercises (Group B).
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Functional Gait Assessment
Time Frame: 10 minutes
|
The primary outcome is the Functional Gait Assessment which is a 10-item test that assesses performance on complex gait tasks (i.e.
walking with head turns, stepping over an obstacle or stopping and turning).
Scores range from 0 to 30.
The highest score is 30 and greater outcomes are indicative of better performance while lower scores are indicative of poorer performance.
The Functional Gait Assessment has been validated in healthy people, older adults with a history of falls and balance impairments, and people with a vestibular disorder.
The minimal detectable change for Functional Gait Assessment is reported to be 6 points in persons with balance and vestibular disorders.
Scores ≤22/30 identify fall risk and are predictable of falls in community-living older persons within 6 months.
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10 minutes
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Functional Gait Dual-Task Test
Time Frame: 45 minutes
|
The FGA in isolation will always be completed first in (primary outcome measure), followed by the dual-task (DT) test conditions, which will be completed in random order.
The cognitive DT condition will involve a numeracy and literacy task and the auditory stimuli will involve restaurant noise.
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45 minutes
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Mini-Balance Evaluation Systems Test
Time Frame: 10 minutes
|
The Mini-Balance Evaluation Test is a measure of dynamic balance (anticipatory postural adjustments, reactive postural control, sensory orientation and dynamic gait).
The Mini-Balance Evaluation Systems Test consists of 14 items, with scores ranging from 0 to 28 points.
Higher scores indicate better outcome while lower scores poorer outcome.
Scores ≤ 20/32 indicate increased falls risk.
|
10 minutes
|
Cambridge Neuropsychological Test Automated Battery
Time Frame: 50 minutes
|
Cambridge Neuropsychological Test Automated Battery is a semiautomated computer program that utilizes a touch screen technology and press pad, to assess neurocognitive function.
The Cambridge Neuropsychological Test Automated Battery core cognition battery is a validated cognitive assessment system for assessing multiple components of cognitive function, including attention, visual memory, spatial memory, executive function and reaction time.
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50 minutes
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Montreal Cognitive Assessment Tool
Time Frame: 5 minutes
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The Montreal Cognitive Assessment Tool is a rapid screening tool for mild cognitive dysfunction.
It assesses different cognitive domains: attention and concentration, executive function, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation.
The scores range from 0-30.
Higher scores indicate better outcomes while lower scores are indicative of poorer outcomes.
It has been recommended that a cut-off scores of 23/30 be used to identify multi-domain cognitive impairment.
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5 minutes
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Speech in Babble Test
Time Frame: 10 minutes
|
The Speech in Babble Test is a low redundancy speech in babble type noise test.
The Speech in Babble Test is presented on a calibrated computer using Matlab software.
There are 8 in total phonemically and phonetically balanced word lists.
The words are presented in the background of a 20-talker babble noise.
Two randomly selected monosyllabic consonant vowel consonant word lists in a background of multitalker babble are presented to each ear (i.e. each ear is tested twice).
The signal to noise ratio during the test is varied adaptively.
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10 minutes
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Standard pure tone audiometry
Time Frame: 10 minutes
|
Standard pure tone audiometry is considered a 'gold' standard test of audiologic examination.
This test will be completed with a portable calibrated audiometer (GSI Pello Standard model with DD45's, IP30 and B81, Serial Number: GS0071085, calibrated by Guymark UK Ltd).
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10 minutes
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Axivity Wrist Band 3-Axis logging accelerometer
Time Frame: 7 days
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Participants' physical activity level will be assessed using a wrist-worn accelerometer, the Axivity Wrist Band 3-Axis logging accelerometer.
The Axivity Wrist Band 3-Axis logging accelerometer captures triaxial acceleration data at 100 Hz with a dynamic range of ±8 g and has been widely used in population-based studies to assess physical activity levels.
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7 days
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Activity-specific Balance Confidence Scale
Time Frame: 3 minutes
|
The Activity-specific Balance Confidence Scale is a self-perceived questionnaire with 16 items and assesses balance confidence in daily activities.
Scores range from 0 to 100.
Higher scores are indicative of better outcome while lower scores indicate poorer outcome.
A score ≤67/100 indicate increased falls risk.
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3 minutes
|
Hospital Anxiety and Depression Scale
Time Frame: 3 minutes
|
The Hospital Anxiety and Depression Scale, a 14-item scale which assesses non-somatic anxiety and depression symptoms, will also be completed.
Scores range from 0 to 21 for each subscale with a score ≥8 proposed for the identification of caseness, for both depression and anxiety.
Higher scores are indicative of poorer outcomes.
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3 minutes
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Pittsburgh Sleep Quality Index
Time Frame: 3 minutes
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The Pittsburgh Sleep Quality Index generates seven component scores: subjective sleep quality, sleep latency, sleep duration habitual sleep efficiency, sleep disturbance, use of sleeping medication, and daytime dysfunction.
The sleep component scores are summed to yield a total score ranging from 0 to 21 with the higher total score (referred to as global score) indicating worse sleep quality while lower scores indicate better outcomes.
In distinguishing good and poor sleepers, a global Pittsburgh Sleep Quality Index score >5 yields a sensitivity of 89.6% and a specificity of 86.5%.
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3 minutes
|
Epworth Sleepiness Scale
Time Frame: 3 minutes
|
The Epworth Sleepiness Scale is a validated and widely used questionnaire exploring daytime sleepiness.
It consists of eight questions that are added together to obtain a single number.
Higher scores indicate sleeping disorder while lower scores are indicative of better outcomes.
Scores range from 0 to 24.
The reference range of 'normal' Epworth Sleepiness Scale scores is 0-10 while Epworth Sleepiness Scale scores of 11-24 represent increasing levels of 'excessive daytime sleepiness'.
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3 minutes
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EQ-5D-5L
Time Frame: 3 minutes
|
The EQ-5D-5L is a generic measure of health status for clinical and economic appraisal.
The EQ-5D-5L descriptive system comprises of 5 dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression).
Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems, and extreme problems.
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3 minutes
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Vertigo Symptom Scale
Time Frame: 3 minutes
|
The VSS is used to assess the frequency and severity of common vestibular (Vertigo Symptom Scale-V; e.g.
vertigo, imbalance) and autonomic/somatic (Vertigo Symptom Scale-A; e.g.
heart pounding, heavy feeling in the arms or legs) symptoms.
Scores range from 0 to 60. Normalised scores range from 0-4, with higher scores indicating a higher (i.e.
worse) level of symptoms while lower scores indicate better outcomes.
|
3 minutes
|
Situational Vertigo Questionnaire
Time Frame: 3 minutes
|
The Situational Vertigo Questionnaire -shortened version measures how frequently symptoms are provoked or exacerbated in environments with visual vestibular mismatch or intense visual motion (e.g.
travelling on escalators, crowds, scrolling computer screens).
Scores range from 0 to 4. Higher scores indicate poorer outcomes while lower scores are indicative of better outcomes.
Scores ≥0.7/4 indicate visual induced dizziness symptoms.
|
3 minutes
|
Dizziness Handicap Inventory
Time Frame: 3 minutes
|
The Dizziness Handicap Inventory is a 25-item self-assessment inventory designed to evaluate self-perceived handicap imposed by symptoms of dizziness.
It consists of three domains: emotional, functional and physical.
Total scores range from 0 to 100, with higher score indicating greater perceived handicap while lower scores are indicative of better performance.
Scores between 0-30, 31-60, and 61-100 on the Dizziness Handicap Inventory indicate mild, moderate, and severe perceived handicap respectively, and can differentiate a person's functional abilities.
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3 minutes
|
Cognitive and Behavioural Symptom Questionnaire
Time Frame: 3 minutes
|
The Cognitive and Behavioural Symptom Questionnaire is a measure of subjects' cognitive (i.e.
beliefs) and behavioural responses to symptoms of their health condition.
This measure includes five cognitive (i.e.
beliefs) subscales: Symptom Focusing, Catastrophizing, Damaging Beliefs, Fear Avoidance and Embarrassment Avoidance; and two behavioural subscales: All or- Nothing and Avoidance/Rest.
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3 minutes
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The Illness Perception Questionnaire-Revised
Time Frame: 3 minutes
|
The Illness Perception Questionnaire-Revised was used to measure participants' illness perceptions.
The Illness Perception Questionnaire-Revised measures the key components in Leventhal's common sense self-regulatory model: Illness identity will measured by asking patients to indicate whether they have experienced and attribute a number of potential symptoms to their dizziness condition.
Scores range from 0 to 24 with higher scores indicating increased illness identity while lower scores indicate better outcomes.
|
3 minutes
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Viktoria Azoidou, Ms
Publications and helpful links
General Publications
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- Neuhauser H, Leopold M, von Brevern M, Arnold G, Lempert T. The interrelations of migraine, vertigo, and migrainous vertigo. Neurology. 2001 Feb 27;56(4):436-41. doi: 10.1212/wnl.56.4.436.
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- Fowler KS, Saling MM, Conway EL, Semple JM, Louis WJ. Paired associate performance in the early detection of DAT. J Int Neuropsychol Soc. 2002 Jan;8(1):58-71.
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- Guerraz M, Yardley L, Bertholon P, Pollak L, Rudge P, Gresty MA, Bronstein AM. Visual vertigo: symptom assessment, spatial orientation and postural control. Brain. 2001 Aug;124(Pt 8):1646-56. doi: 10.1093/brain/124.8.1646.
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- Hall CD, Herdman SJ, Whitney SL, Cass SP, Clendaniel RA, Fife TD, Furman JM, Getchius TS, Goebel JA, Shepard NT, Woodhouse SN. Vestibular Rehabilitation for Peripheral Vestibular Hypofunction: An Evidence-Based Clinical Practice Guideline: FROM THE AMERICAN PHYSICAL THERAPY ASSOCIATION NEUROLOGY SECTION. J Neurol Phys Ther. 2016 Apr;40(2):124-55. doi: 10.1097/NPT.0000000000000120.
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- Whitney SL, Wrisley DM, Brown KE, Furman JM. Is perception of handicap related to functional performance in persons with vestibular dysfunction? Otol Neurotol. 2004 Mar;25(2):139-43. doi: 10.1097/00129492-200403000-00010.
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- Lajoie Y, Gallagher SP. Predicting falls within the elderly community: comparison of postural sway, reaction time, the Berg balance scale and the Activities-specific Balance Confidence (ABC) scale for comparing fallers and non-fallers. Arch Gerontol Geriatr. 2004 Jan-Feb;38(1):11-26. doi: 10.1016/s0167-4943(03)00082-7.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 19/LO/1066
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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