Milrinone on Cardiac Performance During Off-pump Coronary Artery Bypass Surgery

September 26, 2023 updated by: Tae-Yop Kim, MD PhD, Konkuk University Medical Center

Milrinone on Cardiac Performance in Patients Undergoing Off-pump Coronary Artery Bypass Surgery

The purpose of this study is to analyze the changes in cardiac performance before and after milrinone administration in order to find out whether milrinone improves LV performance in patients undergoing coronary artery bypass surgery.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

20

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

valvular heart disease

Description

Inclusion Criteria:

  • patient agree and provide written informed consent.
  • patient undergoing elective coronary artery bypass graft surgery
  • preoperative LV EF>50% (TTE)

Exclusion Criteria:

  • preoperative cardiac dysrhythmia
  • preoperative IABP
  • use of other inotropic agents

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
TMAD
Tissue motion annular displacement (TMAD) of tricuspid valve annulus transesophageal echocardiography
Drug: Milrinone Injection
giving IV milrinone: 50 mcg/kg loading dose by IV push over 10 minutes, then 0.375-0.75 mcg/kg/min IV
Other Names:
  • Milrinone

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
TMAD of ticuspid annulus during early relaxation
Time Frame: 15 mini after milrinone administration
15 mini after milrinone administration

Secondary Outcome Measures

Outcome Measure
Time Frame
global longitudinal strain of the right ventricle
Time Frame: 15 mini after milrinone administration
15 mini after milrinone administration
left ventricular ejection fraction
Time Frame: 15 min after milline administration
15 min after milline administration
global longitudinal strain of the left ventricle
Time Frame: 15 min after milline administration
15 min after milline administration

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Konkuk University Medical Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

September 1, 2024

Primary Completion (Estimated)

December 1, 2024

Study Completion (Estimated)

December 1, 2024

Study Registration Dates

First Submitted

November 4, 2019

First Submitted That Met QC Criteria

November 4, 2019

First Posted (Actual)

November 6, 2019

Study Record Updates

Last Update Posted (Actual)

September 28, 2023

Last Update Submitted That Met QC Criteria

September 26, 2023

Last Verified

September 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • KUH0000000123

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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