Effect of Etomidate and Propofol on Electroencephalography (CHAPE)

May 25, 2022 updated by: Zhihong LU, Air Force Military Medical University, China

Characteristic Changes During Anesthesia With Etomidate and Propofol

Electroencephalography (EEG) monitoring reflect the brain electro-activity. Different anesthetics may show different changes in EEG during anesthesia. Etomidate and propofol are widely used for general anesthesia. The characteristic changes of these two anesthetics may be different.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

68

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • China
    • Shaanxi
      • Xi'an, Shaanxi, China, 710032
        • Recruiting
        • Xijing Hospital
        • Sub-Investigator:
          • Yonghui Wang

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Patients scheduled for surgery under general anesthesia
  • Patients provided written informed consent

Exclusion Criteria:

  • Patients with history of neurological or psychiatric diseases
  • Patients younger than 18 years old
  • Patients scheduled for surgery involved head
  • Patients with pregnancy or planned for breeding

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: etomidate
Drug: etomidate anesthesia
etomidate is used for induction and maintenance of general anesthesia
Experimental: propofol
Drug: propofol anesthesia
propofol is used for induction and maintenance of general anesthesia

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
delta wave deficiency during anesthesia
Time Frame: from anesthesia induction to extubation of the endotracheal tube, on an average of 2.5 hours
from anesthesia induction to extubation of the endotracheal tube, on an average of 2.5 hours

Secondary Outcome Measures

Outcome Measure
Time Frame
spindle wave deficiency during anesthesia
Time Frame: from anesthesia induction to extubation of the endotracheal tube, on an average of 2.5 hours
from anesthesia induction to extubation of the endotracheal tube, on an average of 2.5 hours
burst suppression during anesthesia
Time Frame: from anesthesia induction to extubation of the endotracheal tube, on an average of 2.5 hours
from anesthesia induction to extubation of the endotracheal tube, on an average of 2.5 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Air Force Military Medical University, China

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 28, 2022

Primary Completion (Anticipated)

December 30, 2022

Study Completion (Anticipated)

February 28, 2023

Study Registration Dates

First Submitted

April 27, 2020

First Submitted That Met QC Criteria

April 27, 2020

First Posted (Actual)

April 30, 2020

Study Record Updates

Last Update Posted (Actual)

May 31, 2022

Last Update Submitted That Met QC Criteria

May 25, 2022

Last Verified

May 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • XJH-A-20200330

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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