- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04407351
Develop Novel Phototherapy for Health Care of Patients With Sleep Disorder, Mild Cognitive Impairment, or Dementia
May 27, 2020 updated by: Hsin-Su Yu, Kaohsiung Medical University
Develop Phototherapy of Improving the Quality of Sleep and Healthcare for Patients With Sleep Disorder, Mild Cognitive Impairment, or Dementia: a Novel Light Emitting Diode (LED) Application on Health Promotion
Investigators aim to collaborate with the division of neurology, ophthalmology and dermatology at the Kaohsiung Medical University, and make a new phototherapy for participants suffering from dementia, sleep disorder, mild cognitive dysfunction by using IoT and data science on big health and environmental data.
Study Overview
Status
Completed
Intervention / Treatment
Detailed Description
Solar light is an important environmental factor for all living organisms.
With the advancement of the lighting technology, artificial light, such as light emitting diode (LED), has become another major lighting source.
The influence of blue light and color temperature emitted from LED light source in most of the commercial 3C electronics on human health has been increasingly paid attention.
Light exposure has been reported to be associated with different physiological mechanisms and pathologic events, including sleeping, metabolism and brain dysfunctions.
However, lights are also applied in many therapeutic processes.
Hence, it is a critical issue to develop a next-generation lighting environment for health promotion and improve the competitiveness of green-technology industries in Taiwan by integrating biomedical researches and cutting-edge lighting technology.
For developing next-generation LED industry, the inspection technology and product standard on photobiology safety has been established in Taiwan.
Inspiringly, Researchers in Taiwan have made a LED structure that can emit all the hues of sunlight by changing its terminal voltage, which may further facilitate the use of future lighting device on health promotion.
Based on these technical advancement, in this project, investigators aim to integrate multidisciplinary investigations on animal experiments, translational applications, and clinical trials to establish an good lighting environment for participants with dementia and mild cognitive dysfunction, and bring benefits to Taiwan's green technologies.
To meet this goal, this project aims to integrate lighting and information technologies, including Internet of Things (IoT) and data science analytics, to investigate the lighting effects on human health by conducting animal and translational experiments, and further promote the health in multiple testing groups across different patients.
In this project, investigators incorporate the research strengths in light bioscience, environmental bioscience and medical engineering developed at National Health Research Institutes (NHRI) and the lighting, IoT and data science technologies developed at National Applied Research Laboratories (NARL).
Additionally, investigators aim to collaborate with the division of neurology, ophthalmology and dermatology at the Kaohsiung Medical University, and make a new phototherapy for participants suffering from dementia, sleep disorder, cognitive dysfunction by using IoT and data science on big health and environmental data.
By integrating multi-disciplinary technologies, investigators aim to promote health on brain, mind and body for elderly people and susceptible population by providing a health home lighting environment, which would be potentially beneficial to resolve the emerging issues of aging, sub-health population, psychiatric and neurodegenerative diseases.
Moreover, the safety and molecular mechanism of phototherapy will be validated using animal models.
Industrially, this project will build a strong linkage between LED, information and health promotion industries and upgrade the traditional LED industry by adding the novel application on health promotion.
Study Type
Interventional
Enrollment (Actual)
51
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Kaohsiung City, Taiwan, 807
- Kaohsiung Medical University Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
55 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- (1) The age is between 55 and 80 years old
- (2) Education level is above elementary school graduation
- (3) Use Edinburgh Inventory as the right hand
Exclusion Criteria:
- (1) Neurological diseases, including cerebral stroke, epilepsy, Parkinson's disease and head trauma that cause local nerve signs
- (2) Mental illnesses, including mental disorders, drug addiction, abnormal personality, and poorly controlled schizophrenia;
- (3) Regularly take sedative and sleeping drugs or central nervous system stimulants
- (4) Major physical diseases, including cancer, poorly controlled diabetes, hypertension and thyroid disease, immune rheumatism, heart failure, chronic obstructive pulmonary disease, liver cirrhosis, and chronic kidney disease stages IV and V
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Arm Green LED light - Red LED light
Every morning between 7-8 o'clock, participants will receive 7,500 Lux at home at 470 nm as a full-band (bright light) light-emitting diode (Green LED light) luminaire with a distance of 80-100 cm at a 45-degree angle Light exposure for 30-60 minutes for 12 weeks, the rest of the time indoors is not limited by light.
Then crossover to red light after 2 weeks for wash out.
Every morning between 7-8 o'clock, participants receive 50 Lux of Red LED light (dim light) at their own homes and illuminate at a distance of 80-100 cm at a 45-degree angle for 30-60 minutes for 12 weeks.
|
Investigators arrange 12 weeks green LED light phototherapy.
Investigators arrange 12 weeks red LED light phototherapy (placebo).
|
Other: Arm Red LED light - Green LED light
Every morning between 7-8 o'clock, participants receive 50 Lux of Red LED light (dim light) at their own homes and illuminate at a distance of 80-100 cm at a 45-degree angle for 30-60 minutes for 12 weeks, and the rest of the time indoors is not restricted by light.
Then crossover to green light after 2 weeks for wash out.
Every morning between 7-8 o'clock, participants will receive 7,500 Lux at home at 470 nm as a full-band (bright light) light-emitting diode (Green LED light) luminaire with a distance of 80-100 cm at a 45-degree angle Light exposure for 30-60 minutes for 12 weeks.
|
Investigators arrange 12 weeks green LED light phototherapy.
Investigators arrange 12 weeks red LED light phototherapy (placebo).
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Laser Doppler blood flow analysis (perfusion unit (PU))
Time Frame: Baseline
|
It is a technique for monitoring microvascular perfusion by PeriFlux System 5000 (Perimed, Stockholm, Sweden).
The light source can penetrate tissues and thus can measure blood perfusion without invasive procedures.
The microvascular perfusion situation is immediate results and can be used to quantify the degree of skin damage.
Its unit is perfusion unit (PU).
|
Baseline
|
Laser Doppler blood flow analysis (perfusion unit (PU))
Time Frame: 12 weeks
|
It is a technique for monitoring microvascular perfusion by PeriFlux System 5000 (Perimed, Stockholm, Sweden).
The light source can penetrate tissues and thus can measure blood perfusion without invasive procedures.
The microvascular perfusion situation is immediate results and can be used to quantify the degree of skin damage.
Its unit is perfusion unit (PU).
|
12 weeks
|
Laser Doppler blood flow analysis (perfusion unit (PU))
Time Frame: 26 weeks
|
It is a technique for monitoring microvascular perfusion by PeriFlux System 5000 (Perimed, Stockholm, Sweden).
The light source can penetrate tissues and thus can measure blood perfusion without invasive procedures.
The microvascular perfusion situation is immediate results and can be used to quantify the degree of skin damage.
Its unit is perfusion unit (PU).
|
26 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Hydration
Time Frame: Baseline
|
The skin multi-functional detection system measures the skin's water content to detect whether the skin is too dry.
|
Baseline
|
Hydration
Time Frame: 12 weeks
|
The skin multi-functional detection system measures the skin's water content to detect whether the skin is too dry.
|
12 weeks
|
Hydration
Time Frame: 26 weeks
|
The skin multi-functional detection system measures the skin's water content to detect whether the skin is too dry.
|
26 weeks
|
Transepidermal water loss
Time Frame: Baseline
|
Use the skin multifunctional detection system to measure the skin water loss state to understand the skin health.
|
Baseline
|
Transepidermal water loss
Time Frame: 12 weeks
|
Use the skin multifunctional detection system to measure the skin water loss state to understand the skin health.
|
12 weeks
|
Transepidermal water loss
Time Frame: 26 weeks
|
Use the skin multifunctional detection system to measure the skin water loss state to understand the skin health.
|
26 weeks
|
Sebum
Time Frame: Baseline
|
The measuring principle is to use a photometer to measure the oil point transmittance to determine the size of the oil point and detect the skin oil content.
|
Baseline
|
Sebum
Time Frame: 12 weeks
|
The measuring principle is to use a photometer to measure the oil point transmittance to determine the size of the oil point and detect the skin oil content.
|
12 weeks
|
Sebum
Time Frame: 26 weeks
|
The measuring principle is to use a photometer to measure the oil point transmittance to determine the size of the oil point and detect the skin oil content.
|
26 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Yu WT, Yu HS, Wu CS, Lee CH, Cheng YC, Lin WT, Chen GS, Lan CC. Noninvasive cutaneous blood flow as a response predictor for visible light therapy on segmental vitiligo: a prospective pilot study. Br J Dermatol. 2011 Apr;164(4):759-64. doi: 10.1111/j.1365-2133.2010.10148.x.
- Yang SY, Lan CC. Acquired Port-wine Stain with Local Heat. Acta Derm Venereol. 2016 Feb;96(2):274-5. doi: 10.2340/00015555-2193. No abstract available.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
May 1, 2017
Primary Completion (Actual)
April 30, 2020
Study Completion (Actual)
May 7, 2020
Study Registration Dates
First Submitted
May 10, 2020
First Submitted That Met QC Criteria
May 27, 2020
First Posted (Actual)
May 29, 2020
Study Record Updates
Last Update Posted (Actual)
May 29, 2020
Last Update Submitted That Met QC Criteria
May 27, 2020
Last Verified
May 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- MOST106-3111-Y-043001
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
IPD Plan Description
Investigators do not plan to make individual participant data available to other researchers.
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Sleep Disorder
-
Matrouh UniversitySuez Canal University; Beni-Suef University; University of Bisha, Saudia ArabiaCompletedSleep Disorder | Sleep Hygiene | Sleep Disorder; Insomnia Type | Sleep Disorder in Elderly | Sleep Disorder, Mental Health | Sleep Disorders, Physical HealthEgypt
-
Johns Hopkins UniversityNational Institute on Drug Abuse (NIDA)CompletedSleep Disorder | Diarrhea | Anxiety Disorders | Insomnia | Sleep Initiation and Maintenance Disorders | Anxiety | Sleep Disturbance | Gastrointestinal Dysfunction | Heartburn | Caffeine | Caffeine Withdrawal | Caffeine; Sleep Disorder | Caffeine Dependence | Caffeine-Induced Anxiety Disorder | Caffeine-Induced Sleep... and other conditionsUnited States
-
Johannes Gutenberg University MainzRecruitingSleep Disorder | Restless Legs Syndrome | Insomnia | Sleep Apnea | Narcolepsy | Idiopathic Hypersomnia | Somnambulism | Sleep Disorder Parasomnia | REM Behavior DisorderGermany
-
Yale UniversityCompletedCircadian Rhythm Sleep Disorder, UnspecifiedUnited States
-
The University of Texas Health Science Center,...Active, not recruitingRapid Eye Movement Sleep Behavior DisorderUnited States
-
Merck Sharp & Dohme LLCCompletedDyssomnias | Sleep Disorders | Mental Disorder | Sleep Initiation and Maintenance Disorder; Elderly | Sleep Disorder, Intrinsic
-
Yale UniversityNational Heart, Lung, and Blood Institute (NHLBI)RecruitingCritical Illness | Sleep Deprivation | Circadian Rhythm Sleep Disorder, UnspecifiedUnited States
-
Vanda PharmaceuticalsRecruitingSleep Disorder | Sleep Disturbance | Autism Spectrum Disorder | Neurological DisorderUnited States
-
Assistance Publique Hopitaux De MarseilleAix Marseille UniversitéRecruitingREM Sleep Behaviour DisorderFrance
-
Federal University of Minas GeraisHarvard Medical School (HMS and HSDM)Active, not recruitingDepressive Disorder | Quality of Life | Sleep Disorder | Anxiety Disorders | Insomnia | Spirituality | Stress Disorder | Insomnia Chronic | Insomnia Disorder | Complementary TherapyBrazil
Clinical Trials on Green LED light
-
New York Institute of TechnologyRecruitingPain, Chronic | Ehlers-Danlos SyndromeUnited States
-
University of ArizonaActive, not recruiting
-
University of ArizonaEnrolling by invitation
-
Nova Scotia Health AuthorityActive, not recruiting
-
University of ArizonaRecruiting
-
University of BergenGlamoxCompletedSleep | Sleep Deprivation | Shift-Work Related Sleep DisturbanceNorway
-
Illumacell Inc.Kerber Applied Research; Alberta Health Services - Lower Limb Wound ClinicCompletedDiabetic Foot UlcerCanada
-
Erebouni Medical CenterRecruitingNeonatal Hyperbilirubinemia | Jaundice, NeonatalArmenia
-
Washington University School of MedicineCompletedMelanoma | Breast Cancer | Malignant Melanoma | Cancer of Breast | Cancer of the BreastUnited States
-
University of HelsinkiCompletedBPH (Benign Prostatic Hyperplasia)Finland