- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04449016
Effect of Ethnicity on Changes in VO2max and Cardiac Output in Response to Short-Term High Intensity Interval Training
June 24, 2020 updated by: Todd A. Astorino Ph.D, California State University, San Marcos
The purpose of this study was to determine if ethnicity alters training responsiveness to a low dose of high intensity interval training in inactive women.
Study Overview
Status
Completed
Intervention / Treatment
Detailed Description
Prior to the session, women completed a 4-minute warmup at 10 % PPO.
Each subject completed 9 sessions of HIIT over a 3-week period which consisted of eight to ten 1-minute bouts of cycling at 85% PPO with 75-second recovery between bouts at 10 % PPO.
This protocol is well-tolerated in inactive individuals.
Continuously during each session, heart rate was monitored using telemetry.
On days 1, 3, 6, and 9 of training, the physical activity enjoyment scale (PACES) was completed.
VO2max and cardiac output max were assessed prior to training, as well as post.
Study Type
Interventional
Enrollment (Actual)
22
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
California
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San Marcos, California, United States, 92096
- California State University San Marcos
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 45 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Female
Description
Inclusion Criteria:
- Women
- Between the age of 18-45
- Healthy and non-obese (BMI < 30 kg/m2)
- Perform less than 150 minutes per week of exercise in the last 12 months
- 100% Caucasian or 100% Hispanic
Exclusion Criteria:
- Injured
- Obese
- Active
- Mixed ethnicity
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Non-Randomized
- Interventional Model: Sequential Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Caucasian
Participants performed 9 sessions of HIIT over 3 weeks, utilizing progressive overload by increasing the number of bouts by 1 each week.
They started with 8 bouts on week 1, 9 bouts on week 2, and 10 bouts on week 3.
|
Repeated, brief, and intense exercise bouts separated by active recovery
|
Experimental: Hispanic
Participants performed 9 sessions of HIIT over 3 weeks, utilizing progressive overload by increasing the number of bouts by 1 each week.
They started with 8 bouts on week 1, 9 bouts on week 2, and 10 bouts on week 3.
|
Repeated, brief, and intense exercise bouts separated by active recovery
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in baseline in VO2max at 3 weeks
Time Frame: 3 weeks
|
Each participant performed VO2max testing on an electronically-braked cycle ergometer using a ramp protocol.
During exercise, subjects expired through a plastic mouthpiece and low resistance valve into tubing connected to a mixing chamber.
Measures of ventilation and expired fractions of oxygen and carbon dioxide were obtained throughout exercise by a metabolic cart.
Gas exchange data including VO2, VCO2, and ventilation were time-averaged every 15 seconds.
The test was terminated when the subject's pedal cadence was below 50 rev/min.
|
3 weeks
|
Change in baseline in cardiac output max at 3 weeks
Time Frame: 3 weeks
|
During the VO2max assessment, participants wore a thoracic impedance device to measure heart rate and stroke volume, calculating their cardiac output.
|
3 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Todd Astorino, PhD, California State University, San Marcos
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Astorino TA, White AC, Dalleck LC. Supramaximal testing to confirm attainment of VO2max in sedentary men and women. Int J Sports Med. 2009 Apr;30(4):279-84. doi: 10.1055/s-0028-1104588. Epub 2009 Feb 6.
- Johnson JL, Slentz CA, Duscha BD, Samsa GP, McCartney JS, Houmard JA, Kraus WE. Gender and racial differences in lipoprotein subclass distributions: the STRRIDE study. Atherosclerosis. 2004 Oct;176(2):371-7. doi: 10.1016/j.atherosclerosis.2004.05.018.
- Raleigh JP, Giles MD, Scribbans TD, Edgett BA, Sawula LJ, Bonafiglia JT, Graham RB, Gurd BJ. The impact of work-matched interval training on V̇O2peak and V̇O2 kinetics: diminishing returns with increasing intensity. Appl Physiol Nutr Metab. 2016 Jul;41(7):706-13. doi: 10.1139/apnm-2015-0614. Epub 2016 Feb 29.
- Astorino TA, Schubert MM, Palumbo E, Stirling D, McMillan DW, Cooper C, Godinez J, Martinez D, Gallant R. Magnitude and time course of changes in maximal oxygen uptake in response to distinct regimens of chronic interval training in sedentary women. Eur J Appl Physiol. 2013 Sep;113(9):2361-9. doi: 10.1007/s00421-013-2672-1. Epub 2013 Jun 11.
- Bowdon M, Marcovitz P, Jain SK, Boura J, Liroff KG, Franklin BA. Exercise Training in "At-Risk" Black and White Women: A Comparative Cohort Analyses. Med Sci Sports Exerc. 2018 Jul;50(7):1350-1356. doi: 10.1249/MSS.0000000000001580.
- Gill JM, Celis-Morales CA, Ghouri N. Physical activity, ethnicity and cardio-metabolic health: does one size fit all? Atherosclerosis. 2014 Feb;232(2):319-33. doi: 10.1016/j.atherosclerosis.2013.11.039. Epub 2013 Nov 23.
- Skinner JS, Jaskolski A, Jaskolska A, Krasnoff J, Gagnon J, Leon AS, Rao DC, Wilmore JH, Bouchard C; HERITAGE Family Study. Age, sex, race, initial fitness, and response to training: the HERITAGE Family Study. J Appl Physiol (1985). 2001 May;90(5):1770-6. doi: 10.1152/jappl.2001.90.5.1770.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
June 1, 2017
Primary Completion (Actual)
December 22, 2019
Study Completion (Actual)
March 23, 2020
Study Registration Dates
First Submitted
June 24, 2020
First Submitted That Met QC Criteria
June 24, 2020
First Posted (Actual)
June 26, 2020
Study Record Updates
Last Update Posted (Actual)
June 26, 2020
Last Update Submitted That Met QC Criteria
June 24, 2020
Last Verified
June 1, 2020
More Information
Terms related to this study
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Undecided
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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