Anesthesia and Cancer Study: Renal Cell Carcinoma

The Influence of Type of Anesthesia on Recurrence of Renal Cell Carcinoma After Nephrectomy: a Prospective Randomized Controlled Study

Sponsors

Lead Sponsor: Seoul National University Hospital

Source Seoul National University Hospital
Brief Summary

This study investigates the influence of type of anesthesia on recurrence and survival of renal cell carcinoma in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics, such as sevoflurane or desflurane.

Detailed Description

The effect of anesthesia on cancer recurrence and survival is controversial. According to some retrospective studies and preclinical studies, TIVA is suggested to be more favorable than inhalation anesthesia regarding cancer recurrence and survival after surgery. However, to our knowledge, there is no study which investigates the influence of type of anesthesia on recurrence of renal cell carcinoma after nephrectomy.

Overall Status Not yet recruiting
Start Date September 2020
Completion Date July 2025
Primary Completion Date July 2022
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
one year metastasis-free survival one years after surgery
Secondary Outcome
Measure Time Frame
three year metastasis-free survival three years after surgery
one year survival one year after surgery
three year survival three year after surgery
Enrollment 620
Condition
Intervention

Intervention Type: Drug

Intervention Name: Propofol

Description: Propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia

Arm Group Label: TIVA group

Intervention Type: Drug

Intervention Name: Inhaled General Anesthetics

Description: Sevoflurane or desflurane for induction and maintenance of anesthesia

Arm Group Label: inhalation group

Eligibility

Criteria:

Inclusion Criteria:

- Adult patients scheduled for elective nephrectomy due to renal cell carcinoma

Exclusion Criteria:

- Emergency surgery

- Pregnancy

- Allergies to anesthetics

- Palliative surgery

- Refusal to participate in the study

- History of diagnosis or surgery for other cancer

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Overall Contact

Last Name: Jin-Tae Kim

Phone: 821062608490

Email: [email protected]

Location
Facility: Jin-Tae Kim
Location Countries

Korea, Republic of

Verification Date

August 2020

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Seoul National University Hospital

Investigator Full Name: Jin-Tae Kim

Investigator Title: professor

Keywords
Has Expanded Access No
Condition Browse
Number Of Arms 2
Arm Group

Label: TIVA group

Type: Experimental

Description: Patients receiving the total intravenous anesthesia using propofol

Label: inhalation group

Type: Active Comparator

Description: Patients receiving inhalation anesthesia using sevoflurane or desflurane

Patient Data No
Study Design Info

Allocation: Randomized

Intervention Model: Parallel Assignment

Intervention Model Description: A prospective randomized controlled study

Primary Purpose: Prevention

Masking: Double (Participant, Outcomes Assessor)

Source: ClinicalTrials.gov