Magnesium Versus High Dose Fentanyl in Endotracheal Intubation

Magnesium Versus High Dose Fentanyl in Attenuating Stress Response to Endotracheal Intubation

Sponsors

Lead Sponsor: National Cancer Institute, Egypt

Source National Cancer Institute, Egypt
Brief Summary

this study is designed to assess the efficacy of MgSO4 versus high dose fentanyl in attenuating stress response to intubation

Detailed Description

to assess the effect of MgSO4 compared to high dose fentanyl in attenuating stress response in cancer patients undergoing surgeries under general anesthesia requiring endotracheal intubation

Overall Status Recruiting
Start Date September 5, 2020
Completion Date November 15, 2020
Primary Completion Date November 10, 2020
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
heart rate values 3 months
Secondary Outcome
Measure Time Frame
blood pressure 3 months
coughing during intubation 3 months
Enrollment 48
Condition
Intervention

Intervention Type: Drug

Intervention Name: Magnesium sulfate

Description: drug administration before intubation

Arm Group Label: Magnesium sulphate

Intervention Type: Drug

Intervention Name: Fentanyl Citrate

Description: drug administration with induction of anesthesia

Arm Group Label: Fentanyl

Eligibility

Criteria:

Inclusion Criteria:

- Cancer patients undergoing surgery under general anesthesia requiring endotracheal intubation

- ASA I II

- 18 to 60

Exclusion Criteria:

- allergy to any of the used drugs

- renal or hepatic impairment

- hypertensive patients, patients with cardiovascular or cerebrovascular diseases

Gender: All

Minimum Age: 18 Years

Maximum Age: 60 Years

Healthy Volunteers: No

Overall Official
Overall Contact

Last Name: Walaa Y Elsabeeny, MD

Phone: 01007798466

Phone Ext.: 002

Email: [email protected]

Location
Facility: Status: Contact: Contact Backup: Walaa Y Elsabeeny Walaa Y Elsabeeny, MD 01007798466 002 [email protected]
Location Countries

Egypt

Verification Date

October 2020

Responsible Party

Type: Principal Investigator

Investigator Affiliation: National Cancer Institute, Egypt

Investigator Full Name: Walaa Youssef Elsabeeny

Investigator Title: Lecturer of anesthesia and pain management

Has Expanded Access No
Number Of Arms 2
Arm Group

Label: Magnesium sulphate

Type: Experimental

Description: 30 mg per kg MgSo4 infusion in 100 ml saline over 10 minutes

Label: Fentanyl

Type: Experimental

Description: 4 mic per kg fentanyl i.v

Patient Data Undecided
Study Design Info

Allocation: Randomized

Intervention Model: Parallel Assignment

Primary Purpose: Treatment

Masking: Double (Participant, Outcomes Assessor)

Source: ClinicalTrials.gov