Prognostic Factors and Mortality in Older Stroke Patients With Mechanical Thrombectomy

February 25, 2024 updated by: Far Eastern Memorial Hospital

Prognostic Factors in Disease Progression and Mortality Risk in the Older Stroke Patients With Mechanical Thrombectomy

The study focus on the elderly patient (older than 80 years of age) who had acute ischemic stroke and received mechanical thrombectomy. The investigators analyze different factors in the stage of before, between, after procedure and trying to figure out if there is any difference between the 30-day-mortality group versus non-30-day-mortality group.

Study Overview

Status

Completed

Conditions

Detailed Description

With the constant improvements in health care, standard of living and the decrease birth rate, the percentage of the elderly population ( above 80 years old) is expected to double in Taiwan by the year 2044, according to data from the National Development Council. Consequently with the increase in the proportion of senior citizens, there will be an surge number of patient suffering from cardiovascular and cerebrovascular diseases, most importantly acute ischemic stroke. In recent years, mechanical thrombectomy has become the gold standard in the treatment for acute stroke patients, however, many studies have excluded the patients above the age of 80 years old as the benefits of the procedure have been very controversial and there is no clear evidence proving favorable a outcome. There are a few studies which state that though elderly patients had higher risk of complications when receiving mechanical thrombectomy as compared to younger patients, the prognosis was still superior to those didn't receive any intervention. Previous studies put more emphasis on the overall prognosis, morbidity and mortality rate, they didn't focused on the cause of mortality.

The study focuses on analyzing of the cause of mortality and whether there is a significant difference between 30-day-mortality group versus non-30-day-mortality group.

Study Type

Observational

Enrollment (Actual)

48

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Taiwan
      • New Taipei city, Taiwan, 220
        • Far Eastern Memorial Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

80 years to 110 years (Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

  1. elderly (older than 80 years old)
  2. acute ischemic stroke in anterior circulation
  3. NIHSS more than 8

Description

Inclusion criteria:

  1. elderly (older than 80 years old)
  2. acute ischemic stroke in anterior circulation
  3. NIHSS more than 8

Exclusion Criteria:

  1. posterior infarction
  2. ASPECT score less than 3

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
A
Patient who died in the 30 days after receiving mechanical thrombectomy, no matter the mortality cause
B
Non-30-day-mortality group after receiving mechanical thrombectomy

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
30 days mortality
Time Frame: 30 days
Patient who died in the 30 days after receiving mechanical thrombectomy
30 days

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The cause of mortality
Time Frame: 30 days
Analyse the main cause of mortality
30 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Far Eastern Memorial Hospital

Investigators

  • Principal Investigator: Szu-Hsiang Peng, MD, FEMH

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2020

Primary Completion (Actual)

December 5, 2020

Study Completion (Actual)

December 11, 2020

Study Registration Dates

First Submitted

December 13, 2020

First Submitted That Met QC Criteria

December 13, 2020

First Posted (Actual)

December 17, 2020

Study Record Updates

Last Update Posted (Actual)

February 28, 2024

Last Update Submitted That Met QC Criteria

February 25, 2024

Last Verified

December 1, 2020

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 109125-E

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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