- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04840381
Dietary Habits and Lifestyle of Nonagenarians and Centenarians in the Italian Abruzzo Region
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Several epidemiological studies indicates that diet and physical activity are two pivotal pillars for the maintenance the of the health status and for longevity. These two last factors seem to be strictly linked between them, as demonstrated by some studies on the so called "Blue zones", particular lands in the planet where longevity rate - in terms of nonagenarians and centenarians - is particularly high. In these studies, it has been pointed out that, other than genetics, individuals following dietary regimens with lower consumption of available carbohydrates and processed foods, higher consumption of fruit, vegetables, cereals and pulses and moderate intake of meat, fish and dairy foods live longer and in a healthier status.
The Abruzzo region is characterized by a great gastronomical variability, due also to the particular geographical characterization, with a few kilometer distance between sea and mountains. However, most of these dietary habits tend to stick in a valuable way to Mediterranean Diet, a dietary regimen listed in 2010 in the Representative List of the Intangible Cultural Heritage of Humanity by UNESCO. Intriguingly, the Mediterranean Diet is based on the intake of the above mentioned food groups, plus a recognized key role of the physical activity and conviviality in the meal consumption.
Particularly, in the internal and mountainous part of the Abruzzo region, it has been found that the local citizens followed/follows a typical "dietary practice" called "sdijuno", which in local dialect means "to break the fasting of the night". In fact, "sdijuno" was the first abundant meal of the day - usually at mid-morning, based on the local vegetable-based foods - following the previous frugal dinner and breakfast meals. Thus, it can be hypothesized of 14-16 hours of almost fasting period. This evidence falls into the most recent findings showing the importance to consume meals in the middle part of the day and limiting the caloric intake during evening time, when metabolism tends to decrease according to body circadian rhythm.
Based on these premises, the aim of the present study is to survey the dietary habits of nonagenarians and centenarians of the Abruzzo region - particularly focusing on their adherence to "sdijuno" practice - as well as physical activity and to collect personal data and health status information. Then, it will be investigated whether the adherence to the "sdijuno" dietary practice is relevant among the nonagenarians and centenarians and there is a link between this practice and the longevity of the volunteers. To do this, an ad hoc questionnaire has been set-up and will be administered to register food frequency and meal time, main recipes, physical activity habits, health status.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Contact
- Name: Mauro Serafini, PhD
- Phone Number: +39 0861266939
- Email: mserafini@unite.it
Study Locations
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Teramo, Italy, 64100
- University of Teramo - Faculty of Bioscience and Agro-Food and Environmental Technology
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Age ≥ 90 years old
- Borned and living for most of their life in the Abruzzo region.
Exclusion Criteria:
- Age lower 80 years old.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Nonagenarians and Centenarians
Nonagenarians and Centenarians borned and living for most of their life in the Abruzzo region.
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Administration of an ad hoc questionnaire to register food frequency consumption and meal time, main recipes; phisical activity questionnaire and list of questions concerning the previous and actual health status of participants
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Frequency of intake of food groups
Time Frame: 1 year
|
Observed information regarding the frequency of the consumption different food groups during subejects' period of youth
|
1 year
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Moderate or Vigorous Physical Activity Per Week
Time Frame: 1 Week
|
Self reported practice of moderate or vigorous physical activity per week during subejects' period of youth and old age (minutes-per-week)
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1 Week
|
Mealtime
Time Frame: 1 Day
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Self reported information regarding the daily mealtime during subejects' period of youth and old age (hour and minutes of meal eating)
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1 Day
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Body weight
Time Frame: 1 Day
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Self reported body weight (kg)
|
1 Day
|
Body height
Time Frame: 1 Day
|
Self reported body height (m)
|
1 Day
|
Body Mass Index (BMI)
Time Frame: 1 Day
|
Weight and height will be combined to report BMI in kg/m^2
|
1 Day
|
Collaborators and Investigators
Sponsor
Collaborators
Publications and helpful links
General Publications
- Angelino D, Godos J, Ghelfi F, Tieri M, Titta L, Lafranconi A, Marventano S, Alonzo E, Gambera A, Sciacca S, Buscemi S, Ray S, Galvano F, Del Rio D, Grosso G. Fruit and vegetable consumption and health outcomes: an umbrella review of observational studies. Int J Food Sci Nutr. 2019 Sep;70(6):652-667. doi: 10.1080/09637486.2019.1571021. Epub 2019 Feb 15.
- Gensous N, Franceschi C, Santoro A, Milazzo M, Garagnani P, Bacalini MG. The Impact of Caloric Restriction on the Epigenetic Signatures of Aging. Int J Mol Sci. 2019 Apr 24;20(8):2022. doi: 10.3390/ijms20082022.
- Magrone T, Perez de Heredia F, Jirillo E, Morabito G, Marcos A, Serafini M. Functional foods and nutraceuticals as therapeutic tools for the treatment of diet-related diseases. Can J Physiol Pharmacol. 2013 Jun;91(6):387-96. doi: 10.1139/cjpp-2012-0307. Epub 2013 Apr 12.
- Poulain M, Pes GM, Grasland C, Carru C, Ferrucci L, Baggio G, Franceschi C, Deiana L. Identification of a geographic area characterized by extreme longevity in the Sardinia island: the AKEA study. Exp Gerontol. 2004 Sep;39(9):1423-9. doi: 10.1016/j.exger.2004.06.016.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- CenTEnari
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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