Effect of Interval Training on Arterial Stiffness in Women With Hypertension

this study is aiming to assess the chronic effect of the interval training program on arterial stiffness in women with hypertension

Study Overview

• Status: Completed
• Conditions: Arterial Stiffness
• Intervention / Treatment: Other: interval training exercise

• Study Type: Interventional
• Enrollment (Actual): 50
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Egypt
  • Cairo, Egypt, 17452
    • Faculty of Physical Therapy

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 40 years to 60 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• physically inactive
• BMI 30-40
• Stage 1 and 2 hypertension
• Elevated BP as systolic BP ≥130 mm Hg and/or diastolic BP ≥85 mm Hg measured at the brachial artery.

Exclusion Criteria:

• Medications known to affect weight or appetite
• Any disease associated with exercise intolerance.
• Women were taking hormone replacement therapy

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: interval training; Aerobic interval training. It consisted of a modified interval cycle ergometer training program (3 days a week for 8 weeks). AIT consisted of 8 min warm up, followed by four times of 4-min intervals with HR at 80% of submaximal predetermined HR, with active phases of 3 min of cycling at 60% of submaximal predetermined HR. The exercise session was terminated by 5 min cool down	Other: interval training exercise; interval training exercise
No Intervention: medical treatment; hypertensive medication

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Central arterial stiffness measurements (Pulse Wave Velocity [PWV], augmentation index )	Pulse wave analysis (PWA) of the women in the two groups: pre and post treatment for pulse wave velocity (PWV) and augmentation index(AIx) Pulse Wave Velocity [PWV], augmentation index (AIx @75HR) and resting heart rate were measured using analysis equipment which called Non-invasive blood pressure measurement system using "Mobil-O-Graph 24h PWA " with Hypertension Management Software Client Server (HMS-CS 4.3). PWA was performed using an oscillometric Mobil-O-Graph R 24 h PWA Monitor device (I.E.M GmbH, Germany) with integrated ARCSolver® software	two months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
blood lipid profile	blood analysis will be used to measure lipid profile (high and low-density lipoprotein, cholesterol, triglyceride)	two months
interleukin 6	blood analysis will be used to measure interleukin 6	two months
blood pressure (systolic and diastolic)	resting Blood pressure was monitored from the right arm using an automated digital electronic BP monitor (Omron digital BP monitor, Model 11 EM 403c; Tokyo Japan).	two months

Collaborators and Investigators

• Sponsor: Cairo University

Study record dates

Study Major Dates

• Study Start (Actual): January 25, 2021
• Primary Completion (Actual): March 30, 2021
• Study Completion (Actual): April 15, 2021

Study Registration Dates

• First Submitted: January 12, 2021
• First Submitted That Met QC Criteria: April 23, 2021
• First Posted (Actual): April 28, 2021

Study Record Updates

• Last Update Posted (Actual): March 15, 2022
• Last Update Submitted That Met QC Criteria: March 14, 2022
• Last Verified: March 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Hypertension
• Other Study ID Numbers: P.T REC/012/003094.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No