The Brain Activation During Different Motor Patterns in Healthy Adults

February 20, 2023 updated by: National Taiwan University Hospital

The Brain Activation During Motor Execution, Motor Imagery, Action Observation, and Mirror Visual Feedback in Healthy Adults

This study aims to investigate the brain activation during different motor patterns, including motor execution (ME), motor imagery (MI), action observation (AO) and mirror visual feedback (MVF). In addition, the relations between brain activation and motor performance will also be explored. This study includes two parts, which are upper limb and lower limb part. While executing all the tasks, brain activation in primary motor cortex(M1), premotor cortex(PMC), and supplementary motor cortex(SMA) will be monitored by functional near-infrared spectroscopy. One-way ANOVA with repeated measure will be used to detect the differences of brain activation level between each mode. Pearson correlation coefficient will be used to determine the relations of brain activation and motor performance.

Study Overview

Status

Completed

Conditions

Detailed Description

In upper limb part, subjects will be instructed to execute functional reaching task in ME, MI, AO, and MVF mode. During ME mode, motor performance including maximum speed, maximum acceleration, and jerk will be collected simultaneously. In the lower limb part, subjects will be instructed to walking over ground in ME, MI, and AO mode. During ME mode, the temporal and spatial gait parameters, including speed, stride time, cadence, and stride length will be collected.

Study Type

Observational

Enrollment (Actual)

43

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Taiwan
      • Taipei, Taiwan
        • National Taiwan University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 30 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

The population in this study are heathly adults.

Description

  • Inclusion Criteria

    1. Age between 20 to 30 years.
    2. Right-handed.
    3. Ability to walk 30 meters independently without an assistive device.
    4. No neurogical, cardiopulmonary, or muscle diseases that might interfere with the experiment.
    5. Mini-Mental State Examination (MMSE) score greater than 24.
  • Exclusion Criteria 1. Physiological condition is unstable.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Brain activities over primary motor cortex
Time Frame: Day 1
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Day 1
Brain activities over premotor cortex
Time Frame: Day 1
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Day 1
Brain activities over supplementary motor area
Time Frame: Day 1
A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Day 1

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Motor performance of upper limb -maximum speed
Time Frame: Day 1
cm/s
Day 1
Motor performance of upper limb -maximum acceleration
Time Frame: Day 1
cm/s^2
Day 1
Motor performance of upper limb - jerk
Time Frame: Day 1
cm/s^3
Day 1
Motor performance of lower limb - gait speed
Time Frame: Day 1
cm/s
Day 1
Motor performance of lower limb - cadence
Time Frame: Day 1
steps
Day 1
Motor performance of lower limb - stride time
Time Frame: Day 1
second
Day 1
Motor performance of lower limb - stride length
Time Frame: Day 1
cm
Day 1

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Taiwan University Hospital

Investigators

  • Principal Investigator: Yanci Liu, PHD, National Taiwan University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2021

Primary Completion (Actual)

August 7, 2022

Study Completion (Actual)

August 7, 2022

Study Registration Dates

First Submitted

April 25, 2021

First Submitted That Met QC Criteria

April 27, 2021

First Posted (Actual)

May 3, 2021

Study Record Updates

Last Update Posted (Estimate)

February 22, 2023

Last Update Submitted That Met QC Criteria

February 20, 2023

Last Verified

June 1, 2022

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 202102037RINA

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Neurosciences

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mali

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

3
Subscribe