SNP-based Prediction of Recurrence Risk in Kidney Stone Patients

October 23, 2022 updated by: Guohua Zeng, The First Affiliated Hospital of Guangzhou Medical University

SNP-based Prediction of Recurrence Risk in Kidney Stone Patients: a Prospective Multicenter Observational Study

The goal of this study is to gain new knowledge about genetic risk factors that may affect the kidney stone recurrence. The study seeks to understand if different forms of genes result in an increased risk of kidney stone recurrence.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

In this study, investigators are prospectively testing whether SNP are associated with kidney stone recurrence. Investigators will test the hypothesis that SNP predispose kidney stone patients to recurrence.

Investigators hope to identify predictors for the kidney stone recurrence. This would allow the identification of a subpopulation of kidney stone patients that would benefit most from prevention measures.

Study Type

Observational

Enrollment (Anticipated)

1300

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • China
    • Guangdong
      • Guangzhou, Guangdong, China, 510120
        • Recruiting
        • The First Affiliated Hospital of Guangzhou Medical University
        • Sub-Investigator:
          • Wei Zhu, Ph.D.

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Kidney stone former who the stone was removed completely

Description

Inclusion Criteria:

  • Age 18 or older
  • Kidney stone former who the stone was removed completely.
  • Ability to give informed consent

Exclusion Criteria:

  • Patient refuses or is unable to give consent

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Kidney stone former
Other: No intervention
No intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Stone-free survival
Time Frame: From date of stone-free until the date of first stone recurrence (up to 7 years)
Time to first stone recurrence from stone-free
From date of stone-free until the date of first stone recurrence (up to 7 years)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

The First Affiliated Hospital of Guangzhou Medical University

Collaborators

Xiangya Hospital of Central South University
Shenzhen People's Hospital
ZhuZhou Central Hospital
Zhongda Hospital
Second Affiliated Hospital of Guangzhou Medical University
Huizhou Municipal Central Hospital
The Second Affiliated Hospital of Kunming Medical University
Jiangmen Central Hospital
Baoshan No.2 People's Hospital
Wuhan University Renmin Hospital
The 2nd.Hospital of Tianjin Medical University
301 Hospital
People's Hospital of Xinjiang
Guangdong No.2 People's Hospital
Dehong People's Hospital
Yongzhou Center Hospital
Shenzhen Longgang Central Hospital

Investigators

  • Principal Investigator: Guohua Zeng, M.D., The First Affiliated Hospital of Guangzhou Medical University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2012

Primary Completion (Anticipated)

December 31, 2022

Study Completion (Anticipated)

December 31, 2023

Study Registration Dates

First Submitted

June 10, 2021

First Submitted That Met QC Criteria

June 15, 2021

First Posted (Actual)

June 23, 2021

Study Record Updates

Last Update Posted (Actual)

October 25, 2022

Last Update Submitted That Met QC Criteria

October 23, 2022

Last Verified

October 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • MRER2013-001

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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