- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04938947
Resistance Training and Blood Flow Restriction
Effect of Resistance Training With Blood Flow Restriction on Motor Unit Hypertrophy in the Vastus Lateralis
Study Overview
Status
Detailed Description
Specific Aims and Hypotheses:
Specific Aim 1: To examine the changes of type I and II (different types of muscle fibers) muscle fiber cross-sectional areas in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction. Hypothesis 1: Type I and II fiber cross-sectional area will increase following low-intensity resistance training with blood flow restriction, however, only cross-sectional area of type II fibers will increase post high-intensity resistance training.
Specific Aim 2: To examine changes in the size of the motor units that are active during low and high intensity contractions in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction. Hypothesis 2: The motor units that are active during low and high intensity contractions will increase in size from low-intensity resistance training with blood flow restriction, but only the motor units that are active during high intensity contractions will increase in size from high-intensity resistance training.
Specific Aim 3: To examine changes in whole muscle cross-sectional area as measured via ultrasound pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction. Hypothesis 3: Whole muscle cross-sectional area will increase to similar degrees from both high-intensity resistance training and low-intensity resistance training with blood flow restriction.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Kansas
-
Lawrence, Kansas, United States, 66045
- Robinson Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
-
Exclusion Criteria:
- Participants must not have participated in resistance training more than 5 times in the 6 months preceding the study.
- Participants must be healthy and free of any cardiovascular, metabolic or musculoskeletal conditions that may affect the results of the investigation.
- Participants must not have a history of severe hip, knee and/or ankle injuries, or any other pathological conditions that impair their motor control.
- Participants must not have any pre-existing cardiovascular conditions that involve blood flow/blood clotting.
- Participants who are currently taking blood thinners or any medications regulating blood pressures or heart rate will not be eligible to participate in the study.
- Female participants who are pregnant at the start of or who are planning to become pregnant during the resistance training intervention will not be eligible to participate in the study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: High-Intensity Resistance Training Group
Participants in this group will complete 3 resistance training sessions per week for 6 weeks (18 sessions total).
During each resistance training session, participants will perform 3 sets of bilateral leg-extensions (performed with both legs) to volitional failure (likely 8-12 repetitions) using 80% of their 1-repetition maximum (the most weight they are able to perform 1 complete repetition with, but not 2).
|
This intervention consists of performing high-intensity bilateral (both legs at the same time) leg extensions using 80% of a participants 1 repetition maximum (the maximum weight an individual can complete 1 repetition with, but not 2) to volitional failure.
|
Experimental: Low-Intensity Resistance Training with Blood Flow Restriction Group
Participants in this group will complete 3 resistance training sessions per week for 6 weeks (18 sessions total).
During each training session, participants will perform 3 sets of bilateral leg-extensions (performed with both legs) to volitional failure using 30% of their 1-repetition maximum (the most weight they are able to perform 1 complete repetition with, but not 2).
Participants in this group will perform all leg extensions with blood flow restriction cuffs applied to the proximal thigh of both legs.
The pressure that the cuffs are inflated to will be calculated based on estimates of each subject's arterial occlusion pressure from their thigh circumference.
Once the target pressure is reached, the cuffs will not be deflated until after the final set of the training session.
|
This intervention consists of inflatable cuffs that are designed to partially occlude veinous blood return from the lower extremities during resistance training.
Other Names:
This intervention consists of performing low-intensity bilateral (both legs at the same time) leg extensions using 30% of a participants 1 repetition maximum (the maximum weight an individual can complete 1 repetition with, but not 2) to volitional failure.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Determine changes in muscle fiber cross-sectional area
Time Frame: July 2021-May 2022
|
A primary purpose of the study is to examine the changes of muscle fiber cross-sectional areas in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction
|
July 2021-May 2022
|
Determine changes in motor unit size
Time Frame: July 2021- May 2022
|
Another primary purpose of the study is to examine changes in motor unit size (a non-invasive measure of muscle fiber size) in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and low-intensity resistance training with blood flow restriction
|
July 2021- May 2022
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- STUDY00147374
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Blood Flow Restriction and Low-Intensity Resistance Training
-
Halic UniversityCompletedHigh-Intensity Interval Training | Blood Flow Restriction ExerciseTurkey
-
Riphah International UniversityRecruitingAnterior Cruciate Ligament Reconstruction | Resistance Training | Volleyball | Blood Flow Restriction TherapyPakistan
-
George Fox UniversityRecruitingBlood Flow Restriction TrainingUnited States
-
Baylor UniversityCompletedBlood Flow Restriction Training | Betaine SupplementationUnited States
-
Istanbul Medipol University HospitalBahçeşehir University; Medipol UniversityRecruitingExercise Training | Geriatrics | Blood Flow Restriction TrainingTurkey
-
The Jerzy Kukuczka Academy of Physical Education...RecruitingResistance Training | Blood Flow Restriction | Hypoxia, AltitudePoland
-
Istanbul Medipol University HospitalCompletedHypertrophy | Resistance Training | Osteoarthritis of Knee | Pain, Joint | Blood Flow Restriction Exercise | Occlusion TrainingTurkey
-
University of British ColumbiaRecruitingHypertrophy | Muscle Strength | Resistance Training | High-Intensity Interval TrainingCanada
-
Utah State UniversityWithdrawnBlood Flow RestrictionUnited States
-
Cairo UniversityHeba mohamed Embaby; Salwa ElgendyCompletedHigh Intensity Interval Training | Diet, HealthyEgypt
Clinical Trials on High-Intensity Resistance Training
-
Universidade Federal de Sao CarlosConselho Nacional de Desenvolvimento Científico e TecnológicoCompletedChronic Obstructive Pulmonary DiseaseBrazil
-
Karolinska InstitutetNeuro+CompletedMultiple Sclerosis | Fatigue | Cytokines | Resistance Training | Exercise TherapySweden
-
Rigshospitalet, DenmarkOdense University Hospital; University of Southern DenmarkCompletedMyositis | Dermatomyositis | Polymyositis | Immune-Mediated Necrotizing MyopathyDenmark
-
Universidad Santo TomasUniversidad del Rosario; Universidad Manuela BeltránCompleted
-
Universidad Santo TomasUniversidad Nacional de Colombia; Universidad del RosarioCompletedObesity | Cognitive Function | Motor ActivityColombia
-
Riphah International UniversityCompletedPolycystic Ovary SyndromePakistan
-
University of TorontoUniversity Health Network, TorontoTerminated
-
Riphah International UniversityCompleted
-
Universidad Europea de MadridHospital Infantil Universitario Niño Jesús, Madrid, SpainCompletedAnorexia Nervosa Restricting TypeSpain
-
University of PadovaUniversity of Roma La SapienzaCompletedExercise | Resistance TrainingItaly