Prognostic Factors and Oncological Outcomes in Laparoscopic Liver Resection for CRLM

August 30, 2021 updated by: Dr. M. D'hondt, General Hospital Groeninge

Laparoscopic Liver Resection for Colorectal Liver Metastases: Retrospective Analysis of Prognostic Factors and Oncological Outcomes in a Single-center Cohort

Laparoscopic liver resection (LLR) has gained acceptance as an effective treatment for colorectal liver metastases (CRLM) in selected patients, providing similar oncologic outcomes compared to open liver resection (OLR). A single-center retrospective analysis of a prospectively maintained database was performed. The primary aim of this study was to determine prognostic factors for the survival outcomes associated with LLR for CRLM.

Study Overview

Status

Completed

Conditions

Detailed Description

LLR was defined as pure LLR, including conversions to OLR. In case of missing data, additional details were retrieved from the individual patient file. Data on patient demographics, timing of diagnosis, neoadjuvant chemotherapy (NAC), tumor characteristics (both primary tumor and CRLM), histopathology, molecular characteristics, operative technique (including classification into anatomically major/technically major/minor LR), intra- and postoperative course, adjuvant chemotherapy (AC) as well as oncological outcomes (OS and DFS) were gathered and analyzed. Postoperative complications were graded according to the Clavien-Dindo classification. Complications were classified as major in case of Clavien-Dindo ≥ 3A.

Study Type

Observational

Enrollment (Actual)

200

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

ADULT
OLDER_ADULT
CHILD

Accepts Healthy Volunteers

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Patients who received laparoscopic liver resection for colorectal liver metastases at General Hospital Groeninge between September 2011 and mid-March 2020

Description

Inclusion Criteria:

Patients diagnosed with colorectal liver metastases
Patients who received laparoscopic liver resection for colorectal liver metastases
Patients who received the laparoscopic liver resection between September 2011 and mid-March 2020

Exclusion Criteria:

Patients with contraindication for laparoscopic liver resection
Refusal to participate in the study

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Survival outcomes Time Frame: 9 years	Overall and disease-free survival (Kaplan-Meier method)	9 years
Prognostic factors Time Frame: 9 years	Univariate Cox proportional-hazards regression analysis	9 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

General Hospital Groeninge

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

September 1, 2011

Primary Completion (ACTUAL)

March 15, 2020

Study Completion (ACTUAL)

August 5, 2021

Study Registration Dates

First Submitted

August 23, 2021

First Submitted That Met QC Criteria

August 30, 2021

First Posted (ACTUAL)

September 5, 2021

Study Record Updates

Last Update Posted (ACTUAL)