Precision Nutrition and Food Safety for Dietary Prevention of Chronic Disease Study (PNFS)

January 7, 2024 updated by: Yu Zhang, Zhejiang University

Precision Nutrition and Food Safety for Dietary Prevention of Chronic Disease (PNFS) Study

The associations between food nutrition and safety factors with the risk of chronic diseases are still unclear. This study is conducted in Jinhua, a city with a high prevalence of chronic diseases in China, to assess relations between food nutrition and safety factors and chronic diseases.

Study Overview

Status

Active, not recruiting

Conditions

Detailed Description

Investigations of associations of food nutrition and safety factors with the risk of chronic diseases are limited and studies in China are still lacking. The investigators aim to collect basic characteristics of participants at baseline, including sex, age, smoking, exercise, marriage, education level, dietary factors, and so on, to assess the association of food nutrition and safety factors including various food items, dietary fatty acids, and internal biomarkers of food contaminants such as acrylamide and 3-MCPD with various chronic diseases in a Chinese middle-aged and elderly population. We will use multi-omics technology to investigate the causal mechanisms. Results from this study will be valuable for chronic diseases prevention in China.

Study Type

Observational

Enrollment (Estimated)

2290

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
      • Jinhua, China
        • Lanxi Hospital of Traditional Chinese Medicine
    • Zhejiang
      • Lanxi, Zhejiang, China, 321100
        • Lanxi Red Cross Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

45 years to 75 years (Adult, Older Adult)

Accepts Healthy Volunteers

N/A

Sampling Method

Probability Sample

Study Population

Subjects are eligible residents from 10 government-administered units including 7 urban towns and 3 rural villages of Jinhua, China.

Description

Inclusion Criteria:

  • Subject aged ≥45 and ≤74 years old
  • Subject has complete data on diet and follow-up time

Exclusion Criteria:

had the major illness that had made personal life disabled

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Numbers of participants with metabolic syndrome
Time Frame: From entry into the study baseline:2018 until 2023
metabolic syndrome
From entry into the study baseline:2018 until 2023
Numbers of participants with obesity
Time Frame: From entry into the study baseline:2018 until 2023
Obesity
From entry into the study baseline:2018 until 2023
Numbers of participants with diabetes
Time Frame: From entry into the study baseline:2018 until 2023
Diabetes
From entry into the study baseline:2018 until 2023

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Numbers of participants died
Time Frame: From entry into the study baseline:2018 until 2023
All-cause and cause-specific mortality
From entry into the study baseline:2018 until 2023
Numbers of participants with cardiovascular diseases
Time Frame: From entry into the study baseline:2018 until 2023
Cardiovascular diseases
From entry into the study baseline:2018 until 2023

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Numbers of participants with fatty liver disease
Time Frame: From entry into the study baseline:2018 until 2023
Fatty liver disease
From entry into the study baseline:2018 until 2023

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Zhejiang University

Collaborators

Lanxi Hospital of Traditional Chinese Medicine
Lanxi Red Cross Hospital

Investigators

  • Principal Investigator: Jingjing Jiao, Zhejiang University
  • Principal Investigator: Pan Zhuang, Zhejiang University
  • Study Director: Weifang Zheng, Lanxi Red Cross Hospital
  • Principal Investigator: Yu Zhang, Zhejiang University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2018

Primary Completion (Estimated)

May 1, 2024

Study Completion (Estimated)

July 1, 2028

Study Registration Dates

First Submitted

February 3, 2022

First Submitted That Met QC Criteria

February 9, 2022

First Posted (Actual)

February 21, 2022

Study Record Updates

Last Update Posted (Actual)

January 10, 2024

Last Update Submitted That Met QC Criteria

January 7, 2024

Last Verified

March 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Cohort-PNFS

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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