Neuromuscular Responses to Acute Beetroot Ingestion in Women Older Adults (BEET_ELDERLY)

Neuromuscular Responses to Acute Beetroot Ingestion in Women Older Adults. Performance and Side Effects

Beetroot juice supplementation has shown the capacity for provoking different physiological effects (e.g. vasodilation and muscle contraction increments). However, the effects of beetroot juice ingestion on neuromuscular performance in women older adults are barely studied. In this randomized placebo-controlled study, we investigated the effects of beetroot acute supplementation in improving neuromuscular performance in women older adults

Study Overview

• Status: Completed
• Conditions: Placebo; Dietary Supplement
• Intervention / Treatment: Dietary supplement: beetroot juice

Detailed Description

Beetroot juice supplementation has shown the capacity for provoking different physiological effects that could affect human performance (e.g. vasodilation and muscle contraction increments). Although this dietary supplement has been commonly used for improving sports performance in recreational or professional athletes, the scientific literature in older adults is scarce. Thus, in our knowledge, no previous studies have analyzed the side effects associated to ingestion in this population group. In this randomized placebo-controlled study, we investigated the effects of beetroot acute supplementation in improving neuromuscular performance and side effects associated with ingestion in women older adults.

• Study Type: Interventional
• Enrollment (Actual): 9
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Spain
  • Madrid
    • Pozuelo de Alarcón, Madrid, Spain, 28223
      • Universidad Francisco de Vitoria

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years to 80 years (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• Women >65 or <85 years of age.
• In good health, as determined by the investigator's review of history.

Exclusion Criteria: (based in previous studies on this topic (doi: 10.1093/gerona/glaa311).

Men and women <65 or >85 years of age Unable to provide informed consent Current smokers Significant orthopedic limitations or other contraindications to strenuous exercise Those taking proton pump inhibitors, antacids, xanthine oxidase inhibitors, or on hormone replacement therapy Those taking anti-coagulants or on anti-platelet therapy History of neuromuscular disease (e.g., cervical spondylotic radiculomyelpathy, lumbar spondylosis, amyotrophic lateral sclerosis, Guillain-Barré syndrome, and acquired demyelinating polyneuropathies) Cardiovascular disease (e.g., > stage I hypertension, heart failure, myocardial infarction/ischemia significant myocardial or pericardial diseases (e.g. amyloidosis, constriction), Moderate or severe valvular disease, renal disease, liver disease, or anemia

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Quadruple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Beetroot supplementation; One serving 70 mL of beetroot juice (6.4 mmol of NO3-; Beet-It-Pro Elite Shot, James White Drinks Ltd., Ipswich, UK) 3 h before initiating the testing session.	Dietary supplement: beetroot juice; Acute effects of beetroot juice or placebo juice ingestion
Placebo Comparator: Placebo supplementation; One serving 70 mL of beetroot juice placebo (0.04 mmol of NO3-; Beet-It-Pro Elite Shot, James White Drinks Ltd., Ipswich, UK) 3 h before initiating the testing session.	Dietary supplement: beetroot juice; Acute effects of beetroot juice or placebo juice ingestion

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in maximal isometric handgrip strength (N)	Using a dynamometer and measuring dominant/ non-dominant side	1-week
Changes in 6-m gait speed test	Using a photocell timing gates (seconds)	1-week
Changes in Time Up and Go test	Using a photocell timing gates (seconds)	1-week
Changes in Sit and Stand Test	Using Power Frail APP	1-week
6-Minute Walk Test		1-week

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Rate of perception effort (RPE)	Using a validated scale (1-10 points)	1-week
Side effects questionnarie	Using a side-effects questionnarie (YES/NO scale)	1-week

Collaborators and Investigators

• Sponsor: Universidad Francisco de Vitoria
• Investigators: Principal Investigator: Alvaro López Samanes, PhD, Universidad Francisco de Vitoria

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2022
• Primary Completion (Actual): March 18, 2022
• Study Completion (Actual): April 10, 2022

Study Registration Dates

• First Submitted: April 13, 2022
• First Submitted That Met QC Criteria: April 13, 2022
• First Posted (Actual): April 20, 2022

Study Record Updates

• Last Update Posted (Actual): May 9, 2022
• Last Update Submitted That Met QC Criteria: May 3, 2022
• Last Verified: May 1, 2022

More Information

Terms related to this study

• Keywords: dietary supplements; nitrate; neuromuscular function
• Other Study ID Numbers: uFrancisco_Vitoria_

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No