- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05343247
Dental Age Estimation by Different Methods in Patients With Amelogenesis Imperfecta
Evaluation of Dental Age of Children With Amelogenesis Imperfecta Using Willems Method, Cameriere European Formula, and London Atlas
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
One of the developmental enamel defects, amelogenesis imperfecta (AI), is also known as enamel hypoplasia/hypomineralization. It is a rare inherited disease that affects the enamel structure, amount and component in primary and permanent teeth, and it has been reported to be accompanied by some dental anomalies and nephrocalcinosis. Dental anomalies and nephrocalcinosis can affect tooth development, and there are limited studies examining tooth development in these individuals.Dental age is widely evaluated by pedodontists, forensic dentists and orthodontists. While a delay in tooth development may be associated with growth retardation and learning difficulties, dental age determination can also be used for forensic age determination for children whose birth information is uncertain. A clear assessment of maturation in children with continued growth is important in establishing a dental treatment plan.
Dental age is widely evaluated by pedodontists, forensic dentists and orthodontists. While a delay in tooth development may be associated with growth retardation and learning difficulties, dental age determination can also be used for forensic age determination for children whose birth information is uncertain. A clear assessment of maturation in children with continued growth is important in establishing a dental treatment plan.
There are two basic approaches to dental age determination in children:
- evaluation of eruption of teeth in the oral cavity,
- evaluation of the development and mineralization of crowns and roots on dental radiographs.
In many methods, the developmental stages of different numbers of permanent teeth are used.
The most commonly used method for determining dental age in children; is the Demirjian method that evaluates the development of seven left permanent mandibular teeth in eight stages (from A to H). Willems et al. In 2001, they modified the Demirjian method by conducting a study on the fact that it showed higher age determination in the Belgian Caucasian population. The adapted method was named the Willems method. It is stated that one of the advantages of this method is that it is a relatively simple system for determining tooth age.
One of the most widely used methods of dental age determination recently is the European formula of Cameriere et al., which is calculated based on open apex. It has been reported that this method has been tested on different population groups, and the results are accurate and reliable.
An atlas method was proposed by a group of London researchers in 2010. The Atlas shows all the teeth array images of certain age groups as a schematic series. Age determination is made by deciding which reference image matches the individual's panoramic radiography image more.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Yelda Kasimoglu Eldem, Assoc. Prof.
- Phone Number: 00905336233978
- Email: yelda.kasimoglu@istanbul.edu.tr
Study Locations
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-
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Istanbul, Turkey
- Recruiting
- Istanbul University, Faculty of Dentistry
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Contact:
- Yelda Kasimoglu Eldem, Assoc. Prof.
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- 5-14 years old
- Healthy children
- Children with AI
- Patients without missing left mandibular permanent teeth on panoramic radiography
Exclusion Criteria:
- Children younger than 5 years old and older than 14 years (children that cannot be assessed by the Willems and Cameriere method)
- Poor quality panoramic radiography
- Patients who have received orthodontic treatment
- Patients who received restorative or endodontic treatment
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Children with AI
|
Willems method measures the developmental stages of the seven left permanent mandibular teeth and is frequently used for dental age estimation.
The score of each stage is allocated, and the sum of the scores provides an evaluation of the subject's dental maturity.
Cameriere et al. designed a quantitative approach through a formula based on sex and the ratio between length and apex opening measurements of each lower left tooth.
The London Atlas requires the user to assess the tooth development and eruption and then match it to one of the 31 pictures of age categories.
|
Healthy controls with gender-age match
|
Willems method measures the developmental stages of the seven left permanent mandibular teeth and is frequently used for dental age estimation.
The score of each stage is allocated, and the sum of the scores provides an evaluation of the subject's dental maturity.
Cameriere et al. designed a quantitative approach through a formula based on sex and the ratio between length and apex opening measurements of each lower left tooth.
The London Atlas requires the user to assess the tooth development and eruption and then match it to one of the 31 pictures of age categories.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Correlation coefficient of Willems method.
Time Frame: day 1
|
Dental age of children with AI and healthy controls assessed by the correlation coefficient.
|
day 1
|
Correlation coefficient of London Atlas method.
Time Frame: day 1
|
Dental age of children with AI and healthy controls assessed by the correlation coefficient.
|
day 1
|
Correlation coefficient of Cameriere European formula.
Time Frame: day 1
|
Dental age of children with AI and healthy controls assessed by the correlation coefficient.
|
day 1
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Dental age estimation in children with AI
Time Frame: day 1
|
Dental age estimation in Turkish children
|
day 1
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2021/76
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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