Immediate Effect of Electrical Noise Stimulation on Neuromuscular Adaptation of Balance

Immediate Effect of Electrical Noise Stimulation on Neuromuscular Adaptation During Single-Leg Stance in Healthy Young

Noise stimulation had an immediate effect on improving balance control. The present study aimed to clarify the immediate neuromuscular adaptation induced by noise stimulation and find the correlation between neuromuscular adaptation and functional performance.

Study Overview

• Status: Enrolling by invitation
• Conditions: Electroencephalography; Electromyography; Balanced
• Intervention / Treatment: Device: Sham stimulation; Device: electrical noise stimulation; Device: Foam

Detailed Description

The mechanism behind noise stimulation is called Stochastic Resonance which improves the detectivity of sensory input with the presence of noise, making sub-sensory threshold input detectable. Noise stimulation had been proved to improve postural control, Ia afferent sensitivity, and muscle activity of the tibialis anterior. With this evidence of the effect of noise stimulation on balance enhancement, the neuromuscular adaptation induced by noise stimulation has not been researched yet. Therefore, the present study aims to clarify the immediate effect of noise on neuromuscular regulation during postural control.

• Study Type: Interventional
• Enrollment (Anticipated): 20
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan, 112
    • National Yang-Ming University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years to 36 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• age between 20 and 40 years old
• without ankle injury history in 1 year
• without musculoskeletal or neurological diseases that would affect balance performance
• without visual impairment (except vision correction or no visual problems)
• without vestibular impairment.

Exclusion Criteria:

• subject who cannot tolerate the cutaneous electrical stimulation to induce H reflex
• single-leg stance (SLS) without support is shorter than 80 secs

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Sham stimulation on stable surface; The participant will not receive stimulation and will stand on flat ground.	Device: Sham stimulation; Participants will not receive stimulation.
Experimental: Noise stimulation on stable surface; The participant will receive stimulation with intensity set at 90% of their sensory threshold and will stand on flat ground.	Device: electrical noise stimulation; The intensity of electrical noise stimulation will be set at 90% of the sensory threshold of each participant.
Experimental: Sham stimulation on unstable surface; The participant will not receive stimulation and will stand on foam.	Device: Sham stimulation; Participants will not receive stimulation.; Device: Foam; The foam will be used to make an unstable surface.
Experimental: Noise stimulation on unstable surface; The participant will receive stimulation with intensity set at 90% of their sensory threshold and will stand on foam.	Device: electrical noise stimulation; The intensity of electrical noise stimulation will be set at 90% of the sensory threshold of each participant.; Device: Foam; The foam will be used to make an unstable surface.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mean sway path of the center of pressure	The mean sway path in mm will represent balance performance	40 seconds under each condition
Mean sway velocity of the center of pressure	The mean sway velocity in mm/sec will represent balance performance	40 seconds under each condition
Cortical excitability	Power spectrum density of EEG will calculated for representing cortical excitability.	40 seconds under each condition
Spinal reflex excitability	H reflex amplitude will represent the excitability of peripheral control from spinal level nerve system.	40 seconds under each condition
Co-activation index	Co-activation index will be calculated by EMG activity of Tibialis Anterior and Soleus muscle to represent the muscle activity.	40 seconds after each condition

Collaborators and Investigators

• Sponsor: National Yang Ming University
• Investigators: Study Director: Li-Wei Chou, PhD, National Yang Ming Chiao Tung University

Study record dates

Study Major Dates

• Study Start (Actual): April 29, 2022
• Primary Completion (Anticipated): November 30, 2022
• Study Completion (Anticipated): January 31, 2023

Study Registration Dates

• First Submitted: August 14, 2022
• First Submitted That Met QC Criteria: October 6, 2022
• First Posted (Actual): October 7, 2022

Study Record Updates

• Last Update Posted (Actual): October 7, 2022
• Last Update Submitted That Met QC Criteria: October 6, 2022
• Last Verified: July 1, 2022

More Information

Terms related to this study

• Keywords: Electromyography; Electroencephalography; H reflex; Center of pressure; Electrical noise stimulation
• Other Study ID Numbers: YM111060E

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No
• IPD Plan Description: The informed Consent Form used in this research does not mention IPD sharing.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No