- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05680610
Follow up of Moderate Aortic Regurge After Mitral Valve Replacement
January 10, 2023 updated by: Ahmed wahba, Assiut University
Follow up of Moderate Aortic Regurge After Rhumatic Mitral Valve Replacement
Aim of the study is to follow of of moderate aortic regurge after mitral valve replacement to figure out if the aortic regurge has been improved or it is getting worse
Study Overview
Status
Recruiting
Detailed Description
A considerable proportion of patients who require mitral valve replacement present with a coexisting pathology of the aortic valve (AV).
Rheumatic fever remains the leading cause for combined disease (1) Early series found that one-third of rheumatic hearts exhibited involvement of both mitral and aortic valve.
The rate increased to 99% when the follow-up period was extended to 20 years The treatment of choice in cases in which one of the valves is moderately affected is questionable.
Because combined aortic and mitral valve replacement is usually associated with higher risk and poorer long-term survival than replacement of either of the two valves alone (2) In patients with moderate aortic regurgitation who undergo mitral valve surgery).
according to 2021 ESC/EACTS Guidelines, the decision to treat the aortic valve is controversial, as data show that progression of moderate aortic regurgitation is very slow in patients without aortic dilation (3) in contrast , In 2020 AHA guidelines recommended concomitant aortic valve replacement for moderate aortic regurgitation in patients undergoing surgery for ascending aorta, coronary artery bypass grafting (CABG),or mitral valve surgery (4-10) Because of this is a point of conflict we aim in this study to evaluate the saftey to leave moderate aortic regurge without intertvention as regarding operative time ,postoperative morbidity and mortality and progression of aortic valve regurge.
Study Type
Observational
Enrollment (Anticipated)
100
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Ahmed Wahba
- Phone Number: 01090275757
- Email: Ahmedwahba663@gmail.com
Study Locations
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Assuit
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Assiut, Assuit, Egypt, 71125
- Recruiting
- Faculty of medicine
-
Contact:
- Ahmed Wahba
- Phone Number: 01090275757
- Email: Ahmedwahba663@gmail.com
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
N/A
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
All patients who underwent mitral valve replacement with untrated concomitant moderate aortic regurge in Asyut university hospitals
Description
Inclusion Criteria:
- patients underwent mitral valve replacement for rheumatic heart disease and having moderate aortic valve regurge GRADE 2 in assuit university hospitals
Exclusion Criteria:
- non rhumatic heart disease ,severe aortic regurge ,moderately severe aortic regurge ,combined ischmic and valvular heart diseaese
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Comparison between pre operative degree of aortic regurge and Postoperative degree of aortic regurge after rheumatic mitral valve replacement
Time Frame: 2 years
|
2 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
August 1, 2022
Primary Completion (Anticipated)
August 1, 2024
Study Completion (Anticipated)
October 1, 2024
Study Registration Dates
First Submitted
December 31, 2022
First Submitted That Met QC Criteria
January 10, 2023
First Posted (Estimate)
January 11, 2023
Study Record Updates
Last Update Posted (Estimate)
January 11, 2023
Last Update Submitted That Met QC Criteria
January 10, 2023
Last Verified
January 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Assuit unimed
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Follow up of Moderate Aortic Regurge After Rheumatic Mitral Valve Replacement
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Insel Gruppe AG, University Hospital BernRecruitingAortic Valve Replacement in Patients With Moderate Aortic Stenosis Combined With Mitral RegurgitationSwitzerland
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PSG Institute of Medical Science and ResearchPSG College of PhysiotherapyUnknownProsthetic Replacement of Mitral Valve | Abnormality of Aortic ValveIndia
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Closed Joint-Stock Company NeoCorResearch Institute for Complex Problems of Cardiovascular Diseases, Russia; CT Medical Limited Liability CompanyRecruitingDiseases of Mitral and Aortic Valves | Valvular Heart Disease (Aortic and Mitral Valves) | Rheumatic Disorders of Mitral and Aortic Valves | Other Congenital Malformations of Aortic and Mitral Valves | Mitral Valve Insufficiency and Aortic Valve InsufficiencyRussian Federation
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St. Boniface HospitalCompletedPatients Waiting for Elective Isolated Coronary Artery Bypass Grafting (CABG) | Patients Waiting for Aortic Valve Repair/Replacement for Moderate Aortic Stenosis or Severe Regurgitation | Patients Waiting for Mitral Valve Repair/Replacement for Moderate Stenosis or Severe Regurgitation and other conditionsCanada