EXerCise wEight Loss (EXCEL)

February 26, 2024 updated by: Stuart Gray, University of Glasgow

The Effects of a Home-based Resistance Training Programme on Body Composition and Muscle Function During Weight Loss in People With Overweight or Obesity: a Randomised Controlled Pilot Trial

The overall aim of this study is to investigate the effects of home-based resistance exercise programme on changes in body composition and strength during weight loss, in people living with obesity or overweight.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

48

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Obesity or overweight (BMI ≥ 25kg/m2).
  • Passing the Physical Activity Readiness Questionnaire (PAR-q+)

Exclusion Criteria:

  • Currently take part in more than 1.5 hours of structured exercise per week.
  • Having recently (<6 months) taken part in any resistance exercise training, taking any medications known to affect weight loss.
  • Actively engaged in a weight loss programme, having lost more than 2kg weight in the last 6 months.
  • Any other reason which would limit ability to perform the exercises and outcome measurements safely.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Resistance exercise training + weight loss group (RT+WL)
Participants (WL-RT) will be provided with a resistance exercise booklet containing instructions for exercises and links to demonstration videos. A demonstration and explanation of the exercises will be given at the beginning of the intervention, alongside a discussion of the principles of the programme such as starting level and progression. We will ask participants to perform the resistance exercises for 12-week period. Participants will be asked to perform exercises 3 times a week (3 sets reaching the RPE scale between 8 - 10 out of 10 (4-6 out of 10 in the first week)) for the intervention period. The exercises will include press-ups, band lateral raises, band seated low row, squat, lunge and calf raise.
Behavioral: Resistance exercise training + weight loss group
Doing resistance exercises as well as following the weight watchers weight loss programme for a 12-week period
Experimental: Weight loss only group (WL)
All participants (WL and WL-RT) will be provided with vouchers to access the weight watchers weight loss programme for a 12-week period. Weight Watchers is a commercially available programme and participants will set an initial goal to lose 5kg of body mass. If 5kg weight loss is achieved then the participant can chose further weight loss goals, as long as it would result in a body mass in the weight watchers healthy weight range (https://www.weightwatchers.com/uk/weight-loss/programme/tools/healthy-weight-chart).This plan works on the basis of an individualised points plan that can then be used by the participant to select foods/meals to consume throughout the day.
Behavioral: Weight loss only group (WL)
Only following the weight watchers weight loss programme for a 12-week period

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in whole body lean mass
Time Frame: Change from baseline to 12 weeks
whole body lean mass measured via bio-electrical impedance
Change from baseline to 12 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in whole body fat mass
Time Frame: Change from baseline to 12 weeks
whole body fat mass measured via bio-electrical impedance
Change from baseline to 12 weeks
Change in body mass
Time Frame: Change from baseline to 12 weeks
body mass measured on scales
Change from baseline to 12 weeks
Change in vastus lateralis muscle thickness
Time Frame: Change from baseline to 12 weeks
Muscle thickness of the vastus lateralis muscle measured via ultrasound
Change from baseline to 12 weeks
Change in knee extensor maximal isometric torque
Time Frame: Change from baseline to 12 weeks
Knee extensor maximal isometric torque measured during a maximal voluntary contraction
Change from baseline to 12 weeks
Change in grip strength
Time Frame: Change from baseline to 12 weeks
Grip strength measured with a hand held dynamometer
Change from baseline to 12 weeks
Change in functional physical abilities
Time Frame: Change from baseline to 12 weeks
A 30-second sit-to-stand test measured functional abilities
Change from baseline to 12 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Glasgow

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 1, 2023

Primary Completion (Actual)

February 1, 2024

Study Completion (Actual)

February 1, 2024

Study Registration Dates

First Submitted

January 18, 2023

First Submitted That Met QC Criteria

January 18, 2023

First Posted (Actual)

January 27, 2023

Study Record Updates

Last Update Posted (Estimated)

February 28, 2024

Last Update Submitted That Met QC Criteria

February 26, 2024

Last Verified

February 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • EXerCise wEight Loss Study

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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