- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05859633
Neutrophil/Lymphocyte Ratio in Acute Pancreatitis
Neutrophil/Lymphocyte Ratio in Predicting the Severity of Acute Pancreatitis
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
As one of the most common gastrointestinal diseases in hospitalized patients, the incidence of AP has gradually increased and is 4.9 to 73.4 cases per 100,000 people worldwide in the past few decades, imposing a heavy burden on the health system and leading to long-term hospitalization, most medical costs, and significant mortality.
Up to 10% to 20% of AP patients will develop SAP, and the leading cause of poor prognosis in patients with AP is a vital organ (cardiovascular organs, lung, and kidney) failure and pancreatic necrosis . In clinical practice, varieties of scoring systems are available and have been gradually confirmed, such as the Ranson score, Glasgow score, Acute Physiology and Chronic Health Evaluation (APACHE II), BISAP, and computed tomography severity index (CTSI) . These systems are cumbersome and take a long time to operate, requiring a lot of parameters that are not routinely collected in the early stages of the disease. For example, the BISAP score is characterized by high specificity, but its sensitivity to SAP is not satisfied. Therefore, their early prediction power is not good.
In AP, inflammation first activates a series of inflammatory cytokines, proteolytic enzymes, and anaerobic radioactive nucleic acids to destroy the tissue. The degree of neutrophils decrease is related to the improvement of prognosis of AP, while the degree of lymphocyte increase is related to the severity of the disease. The neutrophil-lymphocyte ratio (NLR) is a more comprehensive biomarker that used neutrophil and lymphocyte counts to respond rapidly to the extent of inflammatory progression and serves as a useful predictive marker to identify the severity of AP. It is well known that AP is a fast-onset inflammation of the pancreas, and an effective prediction of the severity of AP can guide AP patients to receive adequate treatment earlier, contributing to a better prognosis.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Ahmed M Abu-Elfatth
- Phone Number: +18677791
- Email: ahmed111@aun.edu.eg
Study Locations
-
-
-
Assiut, Egypt, 71515
- Recruiting
- Ahmed Mohammed Abu-Elfatth
-
Contact:
- Ahmed M Abu-Elfatth
- Phone Number: 8677791
- Email: ahmed111@aun.edu.eg
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- patients with acute pancreatitis
Exclusion Criteria:
- Patients with acute abdomen with diagnosis other than AP
- Patients with AP who are under age of 18 years old
- Patient's refusal
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
patients with acute pancreatitis
any patient suffers from acute pancreatitis
|
role of Neutrophil/Lymphocyte Ratio in acute pancreatitis
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
severe acute pancreatitis
Time Frame: one year
|
frequency of severe acute pancreatitis
|
one year
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Ahmed M Abu-Elfatth, Assiut University
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Romay
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Acute Pancreatitis
-
Centre Hospitalier Universitaire de NiceRecruiting
-
John Gasdal KarstensenCompleted
-
Tianjin Nankai HospitalCompletedAcute PancreatitisChina
-
Mayo ClinicNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)CompletedAcute Pancreatitis (AP) | Gallstone Pancreatitis | Alcoholic Pancreatitis | Trauma Acute Pancreatitis | Hypertriglyceridemia Acute Pancreatitis | Idiopathic (Unknown) Acute Pancreatitis | Medication Induced Acute Pancreatitis | Cancer Acute Pancreatitis | Miscellaneous (i.e. Acute on Chronic Pancreatitis)United States
-
Northern State Medical UniversityCompleted
-
Erzhen ChenRenJi HospitalUnknownPancreatitis,Acute NecrotizingChina
-
Orlando Health, Inc.Mayo Clinic; University of Alabama at Birmingham; University of Southern California and other collaboratorsActive, not recruitingPancreatitis,Acute NecrotizingUnited States
-
University of OuluCopenhagen University Hospital, HvidovreUnknownAcute Necrotizing PancreatitisFinland
-
Sichuan Academy of Medical SciencesPeking Union Medical College HospitalCompleted
-
Interscope, Inc.CompletedAcute Pancreatitis | Necrotizing Pancreatitis | Acute Pancreatic NecrosisUnited States, Netherlands, Germany
Clinical Trials on Neutrophil/Lymphocyte Ratio in acute pancreatitis
-
Zekai Tahir Burak Women's Health Research and Education...UnknownEclampsia | PreeclampsiaTurkey
-
Assiut UniversityCompletedCopd | COPD ExacerbationEgypt
-
Assiut UniversityCompleted
-
Ain Shams UniversityUnknown
-
Clinica Universitaria Reina Fabiola, Universidad...CompletedAcute DiverticulitisArgentina
-
Centre Hospitalier Universitaire, AmiensCompletedBacterial InfectionsFrance
-
Tanta UniversityRecruiting
-
Tepecik Training and Research HospitalCompletedNeural Tube Defects | Newborn Sepsis
-
Ain Shams UniversityCompletedUrinary Bladder Cancer | BCG | Urinary Bladder Neoplasm | Non-Muscle Invasive Bladder Urothelial Carcinoma | Trans Urethral Resection of a Bladder TumorEgypt
-
Ankara UniversityCompletedCardiac Disease