External Oblique Intercostal Plane Block for Liver Transplantation Donors

External Oblique Intercostal Plane Block for Postoperative Analgesia in Living Liver Donors

Postoperative pain management is one of the important factors to improve rehabilitation and enhance recovery. External oblique intercostal plane block may be used for abdominal wall analgesia to provide effective analgesia for abdominal surgery. The aim of this study is to investigate the postoperative analgesic efficacy of external oblique intercostal plane block and subcostal transversus abdominis plane block in living liver donors.

Researchers will compare the external oblique intercostal plane block group with subcostal transversus abdominis plane block to see if the external oblique intercostal plane block is effective for postoperative analgesia in living liver donors.

Study Overview

• Status: Completed
• Conditions: Liver Transplantation; Postoperative Pain; Donor
• Intervention / Treatment: Other: Subcostal transversus abdominis plane block; Other: External oblique intercostal plane block

Detailed Description

Patients scheduled for living donor hepatectomy will be separated into 2 groups: Subcostal Transversus Abdominis Plane Block Group and External Oblique Intercostal Plane Block Group. Patients in Subcostal Transversus Abdominis Plane Block will be performed subcostal transversus plane block at the end of the surgery and after skin closure and received patient controlled analgesia with morphine for postoperative analgesia. Patients in External Oblique Intercostal Plane Block Group will be performed bilateral External Oblique Intercostal Plane Block at the end of the surgery and after skin closure and received patient controlled analgesia with morphine for postoperative analgesia. Morphine consumption for first postoperative 24 hours, visual analog scale scores, time to need for first rescue analgesia, amount of rescue analgesic drug, incidence of postoperative nausea and vomiting will be recorded.

• Study Type: Interventional
• Enrollment (Actual): 64
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey
  • Istanbul, Turkey
    • Istinye University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Age between 18 and 75 years
• Patients with American Society of Anesthesiology (ASA) physical status I-II
• Patients scheduled for a living donor hepatectomy

Exclusion Criteria:

• Allergy to local anesthetics
• Coagulopathy
• Skin infection at the block area
• Advanced renal failure
• Chronic pain syndromes
• Alcohol or drug abuse
• Psychiatric disorders

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Subcostal transversus abdominis plane block group; The patients in subcostal transversus abdominis plane block group will be received subcostal transversus abdominis plane block and patient controlled analgesia with morphine for postoperative analgesia	Other: Subcostal transversus abdominis plane block; External oblique intercostal plane block will be administered at the end of the surgery and after skin closure.
Active Comparator: External oblique intercostal plane block group; The patients in External oblique intercostal plane block group will be received external oblique intercostal plane block and patient controlled analgesia with morphine for postoperative analgesia	Other: External oblique intercostal plane block; External oblique intercostal plane block will be administered at the end of the surgery and after skin closure. .

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Morphine consumption	The amount of morphine required by the patient and given by the device will be recorded for the first 24 hours.	Postoperative 24 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Postoperative visual analog scale scores	Postoperative pain will be assessed using a visual analog scale (VAS) (from 0 = no pain to 10 = maximum possible pain) for the first 24 hours.	Postoperative 24 hours
Rescue analgesic drug consumption	The amount of rescue analgesic in mg required by the patient will be recorded for the first 24 hours.	postoperative 24 hours
Incidence of postoperative nausea and vomiting	Number of patients developing postoperative nausea and vomiting will be recorded for the first 24 hours	postoperative 24 hours

Collaborators and Investigators

• Sponsor: Istinye University
• Investigators: Principal Investigator: Taylan Sahin, M.D., Istinye University

Study record dates

Study Major Dates

• Study Start (Actual): May 8, 2023
• Primary Completion (Actual): December 14, 2023
• Study Completion (Actual): January 17, 2024

Study Registration Dates

• First Submitted: May 25, 2023
• First Submitted That Met QC Criteria: May 25, 2023
• First Posted (Actual): June 6, 2023

Study Record Updates

• Last Update Posted (Actual): March 19, 2024
• Last Update Submitted That Met QC Criteria: March 18, 2024
• Last Verified: May 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Postoperative Complications; Pain; Neurologic Manifestations; Pain, Postoperative
• Other Study ID Numbers: anestezi2

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No