Dehydration Cognition

Impact of Dehydration and Rapid Rehydration on Cognitive Function

The investigators want to understand the impact of the body losing and gaining water on brain function. Participants will restrict fluids consumed and exercise to lose 5% of body mass. Participants will then be provided fluid equal to the volume lost to consume over 2 hours (recovery). A series of brain function tests will be performed at baseline, following weight loss, and following recovery.

Study Overview

• Status: Completed
• Conditions: Dehydration
• Intervention / Treatment: Behavioral: Fluid loss and consumption

Detailed Description

A baseline series of brain function tests will be performed. Following this, participants will complete a 24 hour fluid and water rich food restriction on the day proceeding testing. Participants will then complete moderate to high intensity exercise in a hot/humid room to achieve 5% body mass loss. Once baseline core body temperature returns to baseline levels, the series of brain function tests will be performed. Participants will then consume a sports drink equal to the volume of sweat lost over the course of a 2 hour recover period. Following this, he series of brain function tests will be performed.

• Study Type: Interventional
• Enrollment (Actual): 15
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • New York
    • Buffalo, New York, United States, 14214
      • University at Buffalo

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy
• Recreationally active
• 18-26 years old

Exclusion Criteria:

• History of cardiovascular, metabolic, respiratory, neural, or renal disease
• Hypertensive (systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg) or tachycardic (resting heart rate ≥ 100 bpm) during the screening visit
• Taking medication or supplements with a known side effect of affecting physiological responses to exercise (e.g., aspirin, acetaminophen, beta blockers, statins, stimulants, depressants, SSRIs)
• Tobacco or nicotine use in the past six months
• Current or past musculoskeletal injury impacting physical activity
• Study physician discretion based on any other medical condition or medication

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Dehydration and Rehydration Arm; Participants will complete exercise until 5% body mass loss, followed by ad libitum rehydration throughout 2 hours of recovery.	Behavioral: Fluid loss and consumption; Upon 5% body mass loss, rehydration of fluid lost to sweating throughout a 2 hour recovery period

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Multitasking test	Accuracy score of a multitasking test (0-100%) with greater scores indicating a better outcome	Upon completion of 5% body mass loss protocol, approximately 2 hours into the trial
Multitasking test	Accuracy score of a multitasking test (0-100%) with greater scores indicating a better outcome	2 hours following the dehydration cognitive function test, approximately 4.5 hours into the trial

Collaborators and Investigators

• Sponsor: State University of New York at Buffalo
• Investigators: Principal Investigator: Riana R Pryor, PhD, University at Buffalo

Study record dates

Study Major Dates

• Study Start (Actual): July 5, 2023
• Primary Completion (Actual): December 22, 2023
• Study Completion (Actual): December 22, 2023

Study Registration Dates

• First Submitted: June 5, 2023
• First Submitted That Met QC Criteria: June 14, 2023
• First Posted (Actual): June 23, 2023

Study Record Updates

• Last Update Posted (Actual): September 19, 2024
• Last Update Submitted That Met QC Criteria: September 11, 2024
• Last Verified: September 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Metabolic Diseases; Water-Electrolyte Imbalance; Dehydration
• Other Study ID Numbers: STUDY00007342

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: Coded data or the methodology will be shared with researchers upon reasonable written request.
• IPD Sharing Time Frame: Data can be shared for as long as the data is retained, at least 7 years.
• IPD Sharing Access Criteria: Data will be shared upon reasonable written request.
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No