PENG and LFCN Block Versus FIC Block for Multimodal Analgesia After Total Hip Replacement Surgery: a Retrospective Analysis (PENG+LFCN-FICB)

June 13, 2023 updated by: Francesco Vetrone, Ospedale Edoardo Bassini

Pericapsular Nerve Group (PENG) Block and Lateral Femoral Cutaneous Nerve (LFCN) Block Versus Fascia Iliaca (FIC) Block for Multimodal Analgesia After Total Hip Replacement Surgery: a Retrospective Analysis

Background: Optimal pain control with limited muscle weakness is paramount for a swift initiation of physical therapy and ambulation. Fascia iliaca compartment block (FICB) has been recommended since it offers the best pain control with low risk of motor block. Pericapsular nerve group block (PENG) with lateral femoral cutaneous nerve (LFCN) block has been proposed as an effective alternative to FICB that offers similar pain control with a considerably lower risk of motor block. This study aimed to compare the afore mentioned blocks and determine which one yielded the lowest NRS score.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This single-center, retrospective investigation was conducted at ASST Nord Milano Bassini hospital. The study was approved by the ethics committee "Comitato Etico Milano Area 3". The main outcome of the study was the comparison of postoperative pain at 6, 12 and 24 hours, expressed as NRS (numeric rating scale), between PENG and LCFN . Secondary outcomes included total opioid consumption expressed as milligrams of morphine equivalents (MME), time to first opioid request, time to first postoperative ambulation.

Study Type

Observational

Enrollment (Actual)

60

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Italy
    • Milano
      • Cinisello Balsamo, Milano, Italy, 20092
        • Ospedale Edoardo Bassini

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

primary hip replacement surgery

Description

Inclusion Criteria:

  • elective total hip replacement surgery for non-traumatic hip disease, age >18 years, complete clinical chart included the type of peripheral nerve block performed, signed consent form for spinal anesthesia and peripheral nerve block.

Exclusion Criteria:

  • incomplete chart, a peripheral nerve block other than PENG or FIC block was performed

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
PENG + LFCN Block
group in which PENG + LFCN Block was performed
Procedure: Peripheral nerve blocks
Peripheral nerve blocks provide intense, site-specific analgesia administring local anesthetics near the nerves.
FIC Block
group in which FIC Block was performed
Procedure: Peripheral nerve blocks
Peripheral nerve blocks provide intense, site-specific analgesia administring local anesthetics near the nerves.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
pain control
Time Frame: 6 hours after surgery
pain assessment with Numeric Rating Scale (NRS): a 0-10 scale, with zero meaning "no pain" and 10 meaning "the worst pain imaginable"
6 hours after surgery
pain control
Time Frame: 12 hours after surgery
pain assessment with Numeric Rating Scale (NRS): a 0-10 scale, with zero meaning "no pain" and 10 meaning "the worst pain imaginable"
12 hours after surgery
pain control
Time Frame: 24 hours after surgery
pain assessment with Numeric Rating Scale (NRS): a 0-10 scale, with zero meaning "no pain" and 10 meaning "the worst pain imaginable"
24 hours after surgery

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
MME of PRN opioid doses
Time Frame: 6 hours after surgery
we studied the effect of Regional anesthesia on opioid-sparing
6 hours after surgery
MME of PRN opioid doses
Time Frame: 12 hours after surgery
we studied the effect of Regional anesthesia on opioid-sparing
12 hours after surgery
Morphine Milligram Equivalents (MME) of "pro re nata" (PRN) opioid doses
Time Frame: 24 hours after surgery
we studied the effect of Regional anesthesia on opioid-sparing
24 hours after surgery

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
time to first opioid request
Time Frame: From date of surgery until up to 3 days after
we studied the effect of Regional anesthesia on opioid-sparing
From date of surgery until up to 3 days after
time to first postoperative ambulation
Time Frame: From date of surgery until up to 100 days after
we studied the effect or Regional anesthesia on residual paralysis
From date of surgery until up to 100 days after

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Ospedale Edoardo Bassini

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 1, 2023

Primary Completion (Actual)

March 1, 2023

Study Completion (Actual)

March 1, 2023

Study Registration Dates

First Submitted

May 19, 2023

First Submitted That Met QC Criteria

June 13, 2023

First Posted (Actual)

June 23, 2023

Study Record Updates

Last Update Posted (Actual)

June 23, 2023

Last Update Submitted That Met QC Criteria

June 13, 2023

Last Verified

June 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 044.677

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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