Effect of Hebal and Synthetic Medicamentss on Enterococcus Feacalis

August 17, 2023 updated by: Alaa Essam Ahmed Abo Laimon, Tanta University

Antimicrobial Efficacy of Synthetic Versus Herbal Intracanal Medicaments Against Enterococcus Faecalis

this study aims to evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

we evaluate the antimicrobial efficacy of two synthetic (Ibuprofen, Modified triple antibiotic paste) and two herbal materials (Curcumin and Olive leaves extract) used as intracanal medication, against E.Faecalis in secondary endodontic infection cases by taking three samples from root canal , the first sample after removing gutta percha from root canal system, the second sample after shaping with protaper universal files and cleaning with 2.5% sodium hypochlorite , the third sample after 7 days from application of the medication .

samples will be diluted into ten fold serial dilution and then the diluted samples will be cultured on bile esculin agar as it is selective media for enterococcus feacalis.

bacterial reduction will be determined and comparision will be made .

Study Type

Interventional

Enrollment (Estimated)

32

Phase

  • Phase 2
  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: alaa essam abo laimon, demonstrator at university
  • Phone Number: 01005690958
  • Email: alaalamona@yahoo.com

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Single rooted teeth.
  • Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula.
  • Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament.

Exclusion Criteria:

  • • Teeth with fractures of the crown or root.

    • Teeth with periodontal pocket deeper than 4mm.
    • Teeth have procedural error like ledge, broken instrument, or perforation.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: group 1
ibuprofen as intracanal medicament
Drug: Ibuprofen 400 mg.
synthetic intracanal medicament
Active Comparator: group 2
modified triple antibiotic paste as intracanal medicament
Drug: modified triple antibiotic paste
synthetic intracanal medicament
Other Names:
  • clindamycin, ciprofloxacin and metronidazole
Active Comparator: group 3
curcumin as intracanal medicament
Dietary supplement: curcumin
herbal intracanal medicament
Active Comparator: group 4
olive leaves as intracanal medicament
Dietary supplement: olive leaves extract
herbal intracanal medicament

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
measurment of microbial reduction as result of applying synthetic and herbaal intracanal medicaments
Time Frame: time necessary for incubation of each sample is 24 hour
sample 1 will be taken after gutta percha removal sample 2 will be taken after cleaning and shaping sample 3 will be taken after apllying the intracanal medicament for one week
time necessary for incubation of each sample is 24 hour

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Tanta University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

August 26, 2023

Primary Completion (Estimated)

October 5, 2023

Study Completion (Estimated)

December 10, 2023

Study Registration Dates

First Submitted

August 17, 2023

First Submitted That Met QC Criteria

August 17, 2023

First Posted (Actual)

August 23, 2023

Study Record Updates

Last Update Posted (Actual)

August 23, 2023

Last Update Submitted That Met QC Criteria

August 17, 2023

Last Verified

August 1, 2023

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • eliminations of E.faecalis

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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