Wrist Position Sense in Individuals With Multiple Sclerosis

Examining the Relationship Between Wrist Position Sense and Manual Dexterity in Individuals With Multiple Sclerosis

No study has been found examining the effect of wrist position sense on manual dexterity in individuals with multiple sclerosis.The purpose of this study is to examine the effect of wrist position sense on manual dexterity of the hand.

Study Overview

• Status: Completed
• Conditions: Multiple Sclerosis
• Intervention / Treatment: Other: Position sense and manual dexterity evaluate

Detailed Description

Multiple sclerosis is a chronic demyelinating disease of the central nervous system that occurs in young adults and usually progresses with attacks and remissions. As the disease progresses, symptoms such as fatigue, muscle weakness, loss of balance, loss of sensation, spasticity, visual disturbances and bladder dysfunction are observed. In addition to these symptoms, hand functions may be affected even in the early stages of the disease.

Appropriate motor control and mobility skills are required to perform manual dexterity effectively. Joint stabilization and perception of the joint's position and movement in space are needed for motor control of hand functions. In this process, position sense signals contribute significantly to the target localization and performance of the hand. Position sense signals must be constantly updated for the coordination and integration of hand position during manual activities such as holding or grasping an object. This is possible with a healthy sense of position.

Although it is known that position sense is affected in MS patients, no study has been found examining the effect of wrist position sense on manual dexterity. The purpose of this study is to examine the effect of wrist position sense on hand dexterity. Patients' manual dexterity will be evaluated using the Purdue Pegboard Test, and wrist position sense will be evaluated using the K-FORCE Sens® electrogoniometer.

• Study Type: Observational
• Enrollment (Actual): 24

Contacts and Locations

Study Locations

• Turkey
  • Deni̇zli̇
    • Denizli, Deni̇zli̇, Turkey, 20160
      • Müge içelli güneş

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

MS and healthy individuals who proper the inclusion and exclusion criteria

Description

Inclusion Criteria:

• Patient group:

  • Disability score (EDSS: Expanded Disability Status Scale) should be between 0-3.
  • Being between the ages of 18-50
  • Not having had an attack in the last 3 months
  • Scoring 24 points or above on the Mini-Mental State Examination
  • Patients diagnosed with relapsing-remitting MS with a disease duration of at least 2 years
  • Patients without spasticity according to MAS

Control group:

• Volunteers in a similar age range who agreed to participate in the study
• Being between the ages of 18-50

Exclusion Criteria:

• Patient group:

  • Presence of diagnosed visual impairment
  • Having other chronic diseases not related to MS
  • Having any orthopedic, neurological, rheumatological or metabolic diagnosis that causes upper extremity involvement
  • History of hand and upper extremity disorders, peripheral nerve disorders, and medical or psychiatric disorders that may significantly affect cognitive function
  • Presence of wrist joint range of motion limitation

Control group:

• Having any orthopedic, neurological, rheumatological or metabolic diagnosis that causes upper extremity involvement
• History of hand and upper extremity disorders, peripheral nerve disorders, and medical or psychiatric disorders that may significantly affect cognitive function
• Presence of wrist joint range of motion limitation

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Multiple sclerosis patient; According to EDSS should be between 0-3, not having had an attack in the last 3 months and without spasticity according to MAS in patient with MS will assesment KFORCE Sens® device and Purdue Pegboard Test.	Other: Position sense and manual dexterity evaluate; Position sense and manual dexterity evaluate
Healthy group; Healthy people of similar age who agree to participate in the study will evaluate the KFORCE Sens® device and the Purdue Pegboard Test.	Other: Position sense and manual dexterity evaluate; Position sense and manual dexterity evaluate

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Wrist Position Sense Assessment	Wrist position sense will be assessed with the KFORCE Sens® electrogoniometer. Target measurement values of 30° for wrist flexion, 30° for extension, 10° for radial deviation and 15° for ulnar deviation will be used.	four mounth

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Purdue Pegboard Test (PPT)	PPT evaluates the gross motor skills of the arm, hand and fingers, as well as the fine motor skills of the fingers and fingertips, both unilaterally and bilaterally. It consists of pins, washers, nuts and assembly tests. The test consists of 5 sub-steps (inserting pins with the dominant/non-dominant hand/both hands, mathematical summation and assembly). The scoring of the test is the total number of pins, washers and nuts installed at the end of the given period. One trial will be made for each subtest.	four mounth

Collaborators and Investigators

• Sponsor: Pamukkale University
• Investigators: Principal Investigator: Müge İçelli Güneş, M.Sc., Pamukkale University Denizli Health Services Vocational School of Higher Education

Study record dates

Study Major Dates

• Study Start (Actual): November 1, 2023
• Primary Completion (Actual): April 1, 2024
• Study Completion (Actual): April 1, 2024

Study Registration Dates

• First Submitted: January 22, 2024
• First Submitted That Met QC Criteria: January 22, 2024
• First Posted (Actual): January 31, 2024

Study Record Updates

• Last Update Posted (Actual): May 8, 2024
• Last Update Submitted That Met QC Criteria: May 7, 2024
• Last Verified: May 1, 2024

More Information

Terms related to this study

• Keywords: Multiple Sclerosis; Position Sense; Manual Dexterity
• Additional Relevant MeSH Terms: Pathologic Processes; Nervous System Diseases; Immune System Diseases; Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Demyelinating Diseases; Autoimmune Diseases; Multiple Sclerosis; Sclerosis
• Other Study ID Numbers: PU-FTR-MI-02

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No