Effectiveness of Neurodynamic Sliding Mobilisation in the "Slump" Position in Relation to the Perceptible Pain Threshold in Asymptomatic People (SPEAKER 2)

Effectiveness of Neurodynamic Sliding Mobilisation in the "Slump" Position in Relation to the Perceptible Pain Threshold in Asymptomatic People, a Cross-over Randomised Controlled Trial

According to the French National Health Agency, the use of manual therapy techniques is "possible" [grade B] as part of a multimodal combination of treatments for low back pain. These include so-called "neurodynamic" neural mobilisations, which aim in particular to desensitise the pain system and activate descending inhibitory pathways, with effects on pain and function in patients with nerve-related low back pain. Most of the available evidence does not explain the mechanisms involved in neural mobilisation in the slump position. Pain reduction is observed in more areas of the body with sliding techniques than with traction techniques.

In this cross-over, randomised controlled trial, we therefore hypothesise that the neurodynamic sliding technique in the slump position acts on mechanisms linked to central pain modulation processes

Study Overview

• Status: Recruiting
• Conditions: Voluntary
• Intervention / Treatment: Other: "slump"position; Other: no" slump" position

• Study Type: Interventional
• Enrollment (Estimated): 54
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: timothée GILLOT, PhD; Phone Number: +33 0232880671; Email: timothee.gillot@chu-rouen.fr
• Study Contact Backup: Name: deborah lebedieff; Email: deborah.lebedieff@chu-rouen.fr

Study Locations

• France
  • Rouen, France, 76000
    • Recruiting
    • Centre d'investigation clinique CIC ROUEN
    • Principal Investigator: Timothée GILLOT

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

Subjects aged 30 years or older and less than 65 years;

• Subjects considered naive to neurodynamic mobilisation techniques;
• Volunteers who have read and understood the information letter and have given their written consent to participate in the study;
• Fluent in spoken and read French;
• Effective contraception in women of childbearing age (progestin-only or intrauterine device or tubal ligation) for at least 12 months;
• For postmenopausal women, a confirmatory diagnosis must be obtained (non-drug-induced amenorrhoea for at least 12 months prior to the enrolment visit);
• Subject affiliated to a social security scheme.

Exclusion Criteria:

• Positive slump test on the day of the selection visit (production of asymmetric lumbar symptoms or painful radiations in at least one lower limb or unilateral reduction in physiological knee extension range of motion compared with the contralateral side);
• Neurological and neuropathic pain assessment score (DN4) greater than 4;
• Increase or decrease in sensory function in the lower limb compared with the contralateral side, as measured by Clinical Sensory Testing (CST);
• Any physical exertion of perceived intensity greater than 17 on the Borg 6-20 scale in the 72 hours prior to the trial and during the trial;
• Injury, complaint or symptom affecting the spine (cervical, thoracic, lumbar) and/or lower limb(s) requiring absence from work, school or leisure activities in the 12 months prior to enrolment;
• History of major surgery, injury to the trunk, spine and/or lower limb(s), or history of progressive rheumatic, neurological or oncological pathology;

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: neurodynamic sliding mobilisation in the "Slump" position; "slump"position	Other: "slump"position; neurodynamic sliding mobilisation in the "slump" position; Other: no" slump" position; placebo
Placebo Comparator: mobilisation, out of the "Slump" position; no "slump"position	Other: "slump"position; neurodynamic sliding mobilisation in the "slump" position; Other: no" slump" position; placebo

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Difference in pressure at the moment when the volunteer indicates that the sensation of pressure becomes pain	Difference in pressure exerted on the territory of the sciatic nerve (gluteal region) at the moment when the volunteer indicates that the sensation of pressure becomes pain, on the dominant lower limb, between the same volunteer during two treatment sessions which differ only in the exposure to neurodynamic sliding mobilisation in the "Slump" position or to mobilisation outside the "Slump" position.	immediately after the mobilisation and 1 day after the mobilisation

Collaborators and Investigators

• Sponsor: University Hospital, Rouen

Study record dates

Study Major Dates

• Study Start (Actual): October 23, 2024
• Primary Completion (Estimated): November 6, 2026
• Study Completion (Estimated): November 6, 2026

Study Registration Dates

• First Submitted: April 4, 2024
• First Submitted That Met QC Criteria: April 4, 2024
• First Posted (Actual): April 10, 2024

Study Record Updates

• Last Update Posted (Actual): May 7, 2026
• Last Update Submitted That Met QC Criteria: May 6, 2026
• Last Verified: February 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: 2021/0373/HP

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No