Transcriptomic Analysis of Incisional Hernia Based on High-throughput Sequencing Technology

April 14, 2024 updated by: Zhijun Bao, Fudan University
This study included patients who underwent surgical treatment for incisional hernia and non-hernia conditions. Surgical specimens were collected for transcriptome sequencing to obtain the gene expression list. Then genes analyzed by Gene Ontology, protein interactions, and signaling pathway enrichment using the expression matrix.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

36

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
      • Shanghai, China
        • Hua Dong Hospital Affiliated to Fu Dan University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

Patients who underwent incisional hernia repair were defined as the experimental group (labelled as the IH group), and patients who underwent laparoscopic cholecystectomy were defined as the control group (labelled as the NC group).

Description

Inclusion Criteria:

1.18 to 75 years 2.diagnosed with incisional hernia 3.normal tumour markers 4.elective surgery patients.

Exclusion Criteria:

  1. patients with vital organ failure (heart liver, lung, kidney and others)
  2. malignant tumors not been completely relieved by active treatment,
  3. patients who have psychiatric diseases or comprehension disorders.
  4. patients with metabolic disease involving connective tissue collagen.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
IH group
Patients who underwent incisional hernia repair were defined as the experimental group (labelled as the IH group)
Diagnostic test: Transcriptomic analysis
high-throughput sequencing technology
NC group
patients who underwent laparoscopic cholecystectomy were defined as the control group (labelled as the NC group)
Diagnostic test: Transcriptomic analysis
high-throughput sequencing technology

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
the gene expression list
Time Frame: 2023.3-2023.9
the gene expression list
2023.3-2023.9

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Fudan University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 1, 2023

Primary Completion (Actual)

September 1, 2023

Study Completion (Actual)

March 1, 2024

Study Registration Dates

First Submitted

March 7, 2024

First Submitted That Met QC Criteria

April 14, 2024

First Posted (Actual)

April 16, 2024

Study Record Updates

Last Update Posted (Actual)

April 16, 2024

Last Update Submitted That Met QC Criteria

April 14, 2024

Last Verified

March 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • HD20240307

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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