Effects of Mulligan Mobilization With Movement as Compared to Kaltenborn Joint Mobilization in the Management of Knee Osteoarthritis

This study is a randomised controlled trial and the purpose of this study is to determine the Effects of Mulligan mobilization with movement as compared to Kaltenborn joint mobilization in the management of knee osteoarthritis." To determine the effects of Mulligan MWM as compared to Kaltenborn joint mobilization in terms of pain, function, range of motion and gait in persons with knee osteoarthritis.

Study Overview

• Status: Enrolling by invitation
• Conditions: Knee Osteoarthritis
• Intervention / Treatment: Device: Heating pad; Device: Transcutaneous electrical nerve stimulation(TENS); Procedure: Mulligan mobilization with movement (MWM); Procedure: Resistance Training exercise; Procedure: Kaltenborn joint mobilization

• Study Type: Interventional
• Enrollment (Estimated): 40
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Pakistan
  • Islamabad, Pakistan
    • Foundation University Islamabad

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Individuals aged 40-70 years (Osama et al, 2022)
• Having KOA history of no less than 3 months
• Knee pain less than 8/10 on numeric pain rating scale (NPRS).
• Radiological evidence of grade III or less on Kellgren classification
• Patients referred from rehab department

Exclusion Criteria:

• Those with signs of serious pathology, such as malignancy, inflammatory disorder or infection.
• History of trauma or fractures in lower extremity.
• Signs of lumbar radiculopathy or myelopathy.
• History of knee surgery or replacement.
• Receiving intra-articular steroid therapy in the preceding two months.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Mulligan MWM group; Group A receiving Mulligan MWM joint mobilization	Device: Heating pad; Heating pad will be used for heating purpose.; Device: Transcutaneous electrical nerve stimulation(TENS); TENS is used for symptomatic pain relief; Procedure: Mulligan mobilization with movement (MWM); It provides short term pain relief and to restore pain-free, functional movements by achieving full range at the joint; Procedure: Resistance Training exercise; Resistance training increases muscle strength by making your muscles work against a weight or force.
Experimental: Kaltenborn mobilization group; Group B receiving Kaltenborn Joint mobilization	Device: Heating pad; Heating pad will be used for heating purpose.; Device: Transcutaneous electrical nerve stimulation(TENS); TENS is used for symptomatic pain relief; Procedure: Resistance Training exercise; Resistance training increases muscle strength by making your muscles work against a weight or force.; Procedure: Kaltenborn joint mobilization; The purpose of joint mobilization is to restore normal, painless joint function. In restricted joints, this involves the restoration of joint play to normalize the roll-gliding that is essential to active movement.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
knee pain	knee pain will be measured using visual analogue scale (VAS) from 0-100mm.A higher score on VAS indicated greater pain.	2 weeks
Functional disability	knee functional disability will be assessed using Knee Osteoarthritis and Outcome Score(KOOS) with a score ranging from 0-100. A lower score on KOOS signifies greater functional disability	2 weeks
Knee range of motion	knee range of motion will be measured using a goniometer. A higher ROM signifies positive outcome.	2 weeks
Stride length	Gait analysis will be done to analyze stride length. A greater stride length signifies positive outcome and prognosis.	2 weeks
Gait velocity	Gait analysis will be done to analyze gait velocity. A greater gait velocity signifies positive outcome and prognosis.	2 weeks
Isometeric Muscle Strength	Isometeric Muscle Strength will be quantified using dynamometer. A higher score on dynamometer signifies greater muscle strength and good prognosis.	2 weeks
Walking related performance fatigability	walking related performance fatigability will be measured using 6 minute walk test. Greater fatigibility indicates poorer outcome.	2 weeks
Functional Capacity	5 repetition sit to stand test will be used to determine knee related functional capacity which will be quantified in terms of time. A smaller time will denote greater functional capacity.	2 weeks

Collaborators and Investigators

• Sponsor: Foundation University Islamabad
• Investigators: Principal Investigator: Shanza Fatima, DPT, Foundation University Islamabad; Principal Investigator: Muhammad Osama, PhD*, Foundation University Islamabad

Study record dates

Study Major Dates

• Study Start (Estimated): June 10, 2024
• Primary Completion (Estimated): December 10, 2024
• Study Completion (Estimated): December 30, 2024

Study Registration Dates

• First Submitted: May 27, 2024
• First Submitted That Met QC Criteria: June 5, 2024
• First Posted (Actual): June 6, 2024

Study Record Updates

• Last Update Posted (Actual): June 6, 2024
• Last Update Submitted That Met QC Criteria: June 5, 2024
• Last Verified: June 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Arthritis; Osteoarthritis; Osteoarthritis, Knee
• Other Study ID Numbers: FUI/CTR/2024/13

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No