Defining Musical Toxicity and Its Effect on Patient Well-being

May 30, 2025 updated by: Mayo Clinic
This study evaluates the experience of musicians who are going through cancer treatment.

Study Overview

Status

Withdrawn

Conditions

Intervention / Treatment

Detailed Description

PRIMARY OBJECTIVES:

I. Describe specific musical difficulties that arise during and after cancer treatments: define "musical toxicity".

II. Discover any interventions or treatments which musicians found helpful while going through cancer treatment.

III. Investigate whether the priority of playing music changed through the course of cancer treatment and beyond, in relation to other priorities including cancer cure and length of life.

IV. Discover treatment and cancer related factors which are correlated with worse musical toxicity.

OUTLINE: This is an observational study. Patients are assigned to 1 of 2 groups.

MUSICAL TOXICITY GROUP: Patients complete a questionnaire, participate in an interview and have their medical records reviewed on study.

NO MUSICAL TOXICITY GROUP: Patients have their medical records reviewed on study.

Study Type

Observational

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Minnesota
      • Rochester, Minnesota, United States, 55905
        • Mayo Clinic in Rochester

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients who are active or accomplished musicians undergoing cancer treatment.

Description

Inclusion Criteria:

  • * Adults ≥ 18 years or older

    • Active or accomplished musicians

      • Those performing in the community as part of a group or as a soloist
      • Those teaching lessons in an individual or group setting
      • Those for whom music teaching or performance is a primary source of income
      • Those who play music multiple times per week

    • Our ideal cohort will consist of an equal number of patients with the following malignancies above the diaphragm:

      • Brain
      • Head and Neck
      • Esophagus or Lung
      • Breast

    • Our ideal cohort will consist of an equal number of patients who engage in the following musical endeavors:

      • Stringed instruments
      • Wind instruments (including woodwind and brass instruments)
      • Keyboard instruments
      • Vocalists

Exclusion Criteria:

  • * < 18 years

    • Did not regularly attempt to engage in musical endeavors during or after cancer treatment
    • Not willing or able to complete the questionnaire or engage in a one-hour interview (i.e. limited English proficiency)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Observational Musical Toxicity Group
Patients complete a questionnaire, participate in an interview and their medical records reviewed on study.
Other: Non-Interventional Study
Non-Interventional Study
Observational No Musical Toxicity Group
Patients have their medical records reviewed on study.
Other: Non-Interventional Study
Non-Interventional Study

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Describe specific musical difficulties that arise during and after cancer treatments - MTQ 10-item
Time Frame: Baseline
Assessed using the Musical Toxicity Questionnaire (MTQ 10-item), a survey with yes/no and open-ended questions (e.g., What musical instrument do you play, or do you sing?). The survey is designed to capture the participant's thoughts and feelings on how cancer treatments (before and after) has affected enjoyment and ability to play, teach, or perform music. The questionnaire will take about 15-30 minutes to complete. Qualitative analysis software will be utilized to code responses and organize themes. Themes will be organized into related groups and interpreted to generate conclusions.
Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mayo Clinic

Investigators

  • Principal Investigator: Dean A. Shumway, M.D., Mayo Clinic in Rochester

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 15, 2024

Primary Completion (Actual)

May 19, 2025

Study Completion (Actual)

May 19, 2025

Study Registration Dates

First Submitted

July 2, 2024

First Submitted That Met QC Criteria

July 2, 2024

First Posted (Actual)

July 10, 2024

Study Record Updates

Last Update Posted (Actual)

June 4, 2025

Last Update Submitted That Met QC Criteria

May 30, 2025

Last Verified

May 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • ROR2333 (Other Identifier: Mayo Clinic in Rochester)
  • NCI-2024-05423 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
  • 23-012760 (Other Identifier: Mayo Clinic Institutional Review Board)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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