High-intensity Interval Training and Vitamin D Effects on Bone Metabolism Among Women Diagnosed With Osteoporosis

Concurrent Effects of High-intensity Interval Training and Vitamin D Supplementation on Bone Metabolism Among Women Diagnosed With Osteoporosis

The effects of 16-week high-intensity interval training (HIIT) and vitamin D supplements on bone mineral density (BMD) in women with osteoporosis. The participants assigned for HITT exercise training with or without vitamin D supplements for 16 weeks, and the levels of serum bone parameters like, Osteocalcin (OC), Ca, and s-BAP were estimated in women with osteoporosis at baseline and after post-training interventions. In addition, the levels of Vitamin D were also identified in all women's accordingly.

Study Overview

• Status: Completed
• Conditions: Osteoporosis; Exercise Overtraining; Vitamin D 25-Hydroxylase Deficiency
• Intervention / Treatment: Other: vitamin D supplements fo 16 weks

Detailed Description

our study aimed to investigate the effects of 16-week high-intensity interval training (HIIT) and vitamin D supplements on bone mineral density (BMD) in women with osteoporosis. thus, Serum levels of 25-Hydroxy-vitamin D (OH-D), Osteocalcin (OC), Ca, and s-BAP were estimated in women with osteoporosis at baseline and after post-training interventions. One-hundred twenty sedentary women aged (30-50 years) were diagnosed with osteoporosis. Patients were classified into four groups, 30 patients in each group; Control group (normal daily activities); Exercise group (HIIT-exercise for 16 weeks); Vitamin D group (vitamin D 800IU/ day for 16 weeks), and Concurrent group (HIIT exercise plus vitamin D for 16 weeks). Anthropometric measurements, BMD, serum levels of vitamin 25-(OH) D, Osteocalcin, s-BAP, and calcium were estimated in all participants' pre- and post-exercise training.

• Study Type: Observational
• Enrollment (Actual): 120

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

a healthy, no-smoking premenopausal women aged (30-50) years old subjects who diagnosed with osteoporosis based on the clinical features and diagnosis evidence of bone mineral density (BMD) measured from both lumbar spine L2 to L4, and from the right and left sides of the hip region by Dual Energy X-ray Absorptiometry (DEXA, UNIGAMMA PLUS AC 230V 50/60Hz 400w, USA) scan method were invited to participate in this study

Description

Inclusion Criteria:

• A healthy non-smoker premenopausal women's
• Age are 30-50 years old
• subjects who diagnosed with osteoporosis based on the clinical features of bone mineral density (BMD) measured from both lumbar spine L2 to L4, and from the right and left sides of the hip region by Dual Energy X-ray Absorptiometry (DEXA, UNIGAMMA PLUS AC 230V 50/60Hz 400w, USA) scan method.

Exclusion Criteria:

• Women with; physical disability,
• abnormal hormonal levels
• severe disease complications such as chronic kidney and liver diseases,
• rheumatoid and osteoarthritis diseases
• significant overweight (BMI ≥25) and obesity (≥30 kg/m2) per recommended by the World Health Organization
• history of receiving calcium, multivitamin supplements, corticosteroids, anticonvulsants, and heparin which might affects up on the assessment of bone markers and BMD measurements were excluded from this study.

Study Plan

How is the study designed?

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
control group; Participants are women with osteoporosis Characterized by normal daily activities and diets	Other: vitamin D supplements fo 16 weks; subjects exercised by HIIT-exercise for 16 weeks; Other Names: HIIT-exercise for 16 weeks
Exercise group; Participants are women's with osteoporosis participated in HIIT-exercise program interventions for 16 weeks	Other: vitamin D supplements fo 16 weks; subjects exercised by HIIT-exercise for 16 weeks; Other Names: HIIT-exercise for 16 weeks
Vitamin D group; Participants are women's with osteoporosis who received vitamin D 800IU/ day for 16 weeks	Other: vitamin D supplements fo 16 weks; subjects exercised by HIIT-exercise for 16 weeks; Other Names: HIIT-exercise for 16 weeks
Concurrent group; Participants are women's with osteoporosis who shared for HIIT exercise program plus vitamin D for 16 weeks	Other: vitamin D supplements fo 16 weks; subjects exercised by HIIT-exercise for 16 weeks; Other Names: HIIT-exercise for 16 weeks

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Anthropometric measurements	BMI measurements were evaluated	4 month

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Assessments of bone mineral density (BMD)	Before and after training along with vitamin D supplements, BMD of the lumbar spine	4 month
Assessments of bone serum markers and vitamin 25(OH) D	Considering the fifth day of the female monthly period (8-10 hours fasting), blood samples were taken from all participants following overnight fasting and within 48 hours before starting the test and just following 16-week exercise training and receiving vitamin D supplements.	4 month

Collaborators and Investigators

• Sponsor: King Saud University

Study record dates

Study Major Dates

• Study Start (Actual): July 15, 2016
• Primary Completion (Actual): March 30, 2017
• Study Completion (Actual): May 25, 2017

Study Registration Dates

• First Submitted: September 29, 2024
• First Submitted That Met QC Criteria: October 1, 2024
• First Posted (Actual): October 3, 2024

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: December 26, 2024
• Last Verified: December 1, 2024

More Information

Terms related to this study

• Keywords: Exercise training, BMD, osteoporosis, Vitamin D deficiency
• Additional Relevant MeSH Terms: Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Bone Diseases, Metabolic; Osteoporosis; Physiological Effects of Drugs; Bone Density Conservation Agents; Micronutrients; Vitamins; Vitamin D
• Other Study ID Numbers: RRC-2016-028

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No