Effects of SIT Combined with Remote Ischemic Preconditioning on Vascular Function in Young Women with Masked Obesity

October 28, 2024 updated by: Beijing Sport University

Effects of Sprint Interval Training Combined with Remote Ischemic Preconditioning on Vascular Function in Young Women with Masked Obesity

Comparison of the effects of combined Sprint Interval Training (SIT) with Remote Ischemic Preconditioning (RIPC) and SIT on vascular function in young women with masked obesity.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This is a randomized clinical trial of single-blind with 3 arms (control group, SIT group and SIT with RIPC group), in which a pre-treatment-posttest design has been used.

Study Type

Interventional

Enrollment (Actual)

44

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
      • Beijing, China
        • School of Sports Medicine and Rehabilitation, Beijing Sport University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Females aged between 18 and 30 years;
  • BMI within the normal range (18.5～24.9 kg/m²), BF% > 30%;
  • Participants with no clinically diagnosed contraindications for exercise, in good health, and not engaged in regular exercise, as determined by the health and physical activity questionnaire (based on the American College of Sports Medicine's guidelines for exercise testing and prescription).

Exclusion Criteria:

  • History of cardiovascular diseases, including coronary heart disease, stroke, or peripheral arterial disease diagnosed through vascular imaging techniques;
  • Currently participating in other intervention studies, including dietary, nutritional, or psychological education programs;
  • Those with regular professional training;
  • Musculoskeletal disorders that make long-term exercise interventions unsuitable.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
No Intervention: Control group
Active Comparator: sprint interval training group
Behavioral: SIT
sprint interval training
Active Comparator: sprint interval training combined with remote ischemic preconditioning group
Behavioral: SIT combined RIPC
sprint interval training combined with remote ischemic preconditioning

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Intima-Media Thickness (IMT)
Time Frame: 8 weeks
Changes in Intima media thickness before and after intervention.
8 weeks
Flow-Mediated Dilation (FMD)
Time Frame: 8 weeks
Changes in Flow-mediated dilation before and after Intervention. Brachial artery flow-mediated dilation (FMD) was measured by the UNEXEF high-resolution ultrasound vascular endothelial function analyzer.
8 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Body Composition Indicator
Time Frame: 8 weeks
Changes in Body composition indicators before and after Intervention. Including body fat percentage (BF%).
8 weeks
Human Morphometric i Indicators
Time Frame: 8 weeks
Changes in Human morphometric indicators before and after Intervention. Including height, weight, waist circumference, hip circumference, and body mass index (BMI). BMI was calculated based on the measured height and weight using the formula: BMI = weight/height² (kg/m²).
8 weeks
Blood Pressure (BP)
Time Frame: 8 weeks
Changes in blood pressure before and after intervention. Including systolic and diastolic blood pressure.
8 weeks
Nitric Oxide (NO)
Time Frame: 8 weeks
Changes in concentration of nitric oxide before and after Intervention.
8 weeks
Maximum Oxygen Uptake (VO2max)
Time Frame: 8 weeks
Changes in maximum oxygen uptake before and after Intervention.
8 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Beijing Sport University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 28, 2023

Primary Completion (Actual)

October 30, 2023

Study Completion (Actual)

December 30, 2023

Study Registration Dates

First Submitted

October 24, 2024

First Submitted That Met QC Criteria

October 28, 2024

First Posted (Actual)

October 29, 2024

Study Record Updates

Last Update Posted (Actual)

October 29, 2024

Last Update Submitted That Met QC Criteria

October 28, 2024

Last Verified

September 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • ESITCRIPVFYWMO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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