Post Operative Sensitivity of MTA Obturation

Effects of Three Different Root Canal Filling Materials Used in Single-Session Root Canal Treatment on Postoperative Pain: A Randomized Clinical Study

The aim of this study was to investigate the difference in postoperative pain caused by different root canal sealers in patients with irreversible pulpitis symptoms and no apical lesions.

Study Overview

• Status: Completed
• Conditions: Endodontic Disease; Endodontically Treated Teeth; Dental Pulp Disease
• Intervention / Treatment: Drug: MTA

• Study Type: Observational
• Enrollment (Actual): 54

Contacts and Locations

Study Locations

• Turkey (Türkiye)
  • Kayseri, Turkey (Türkiye), 38000
    • Erciyes University Faculty of Dentistry

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

Systemically healthy patients between the ages of 18-65

Description

Inclusion Criteria:

• asymptomatic tooth with delayed positive response to thermal tests and electric pulp tests
• large pulp perforation during caries removal,
• inflamed pulp in which bleeding could not be controlled within 5 min,
• periodontally healthy mature mandibular first or second molar tooth.

Exclusion Criteria:

• patients if they were diabetic, immunocompromised, pregnant,
• had a positive history of antibiotic use during the past 1 month,
• required antibiotic prophylaxis
• used analgesic within 7 days prior to the beginning of treatment,
• were allergic to the materials used during root canal treatment,
• if the bleeding could be controlled within 5 min and vital pulp treatment could be performed,
• the tooth had negative response to vitality tests and/or was symptomatic,
• had an associated periapical lesion visible on a radiograph,
• needed a post-core or was planned to serve as prosthetic support,
• had a calcified root canal and internal or external root resorption,
• had tooth with open apex
• mandibular third molars

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
powder-liquid MTA; The root canal will be filled with MTA at the end of the first session and patients will fill out a post-op pain form for 1 week.	Drug: MTA; MTA is primarily composed of tricalcium silicate, dicalcium silicate, bismuth oxide (for radiopacity), and small amounts of calcium sulfate. MTA is highly biocompatible, making it suitable for use in the root canal system and areas in close contact with tissues.
Putty MTA; The root canal will be filled with putty MTA at the end of the first session and patients will fill out a post-op pain form for 1 week.	Drug: MTA; MTA is primarily composed of tricalcium silicate, dicalcium silicate, bismuth oxide (for radiopacity), and small amounts of calcium sulfate. MTA is highly biocompatible, making it suitable for use in the root canal system and areas in close contact with tissues.
Epoxy resin sealer; The root canal will be filled with epoxy resin sealer and gutta-percha at the end of the first session and patients will fill out a post-op pain form for 1 week.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
7-day postoperative pain after root canal treatment	At the end of the visit, patients were educated to record their postoperative pain level by assigning a number between 0 and 10 using the numerical rating scale (NRS) chart. They were categorized into four: 0=no pain, 1-3=mild pain, 4-6=moderate pain, and 7-10=severe pain. The patients were asked to record their pain level preoperatively, at 6, 12, and 24 h, and daily for up to 7 days, and return it to he investigators at a specific time.	7 days

Collaborators and Investigators

• Sponsor: TC Erciyes University

Study record dates

Study Major Dates

• Study Start (Actual): January 30, 2025
• Primary Completion (Actual): December 1, 2025
• Study Completion (Actual): December 15, 2025

Study Registration Dates

• First Submitted: December 22, 2024
• First Submitted That Met QC Criteria: January 25, 2025
• First Posted (Actual): January 28, 2025

Study Record Updates

• Last Update Posted (Estimated): January 2, 2026
• Last Update Submitted That Met QC Criteria: December 27, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Keywords: MTA; Post-op pain; Epoxy resin sealer; putty MTA
• Additional Relevant MeSH Terms: Pain; Neurologic Manifestations; Stomatognathic Diseases; Postoperative Complications; Pathologic Processes; Tooth Diseases; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Pain, Postoperative; Dental Pulp Diseases; Tooth, Nonvital; Amino Acids, Peptides, and Proteins; Heterocyclic Compounds; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Guanine; Hypoxanthines; Purinones; Purines; Glutamates; Amino Acids, Acidic; Amino Acids; Amino Acids, Dicarboxylic; Pemetrexed
• Other Study ID Numbers: AAvci

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No