The Ventilation During In-hospital Cardiac Arrest Study (VENT-IHCA)

March 27, 2026 updated by: University of Aarhus

The Ventilation During In-Hospital Cardiac Arrest (VENT-IHCA) Study

The goal of this prospective observational study is to learn how ventilation quality parameters during cardiopulmonary resuscitation (CPR) are associated with short-term survival following in-hospital cardiac arrest of adult patients.

The main questions it aims to answer are:

What ventilation volume during CPR is associated with the highest chance of return of spontaneous circulation (ROSC)? What ventilation rate during CPR is associated with the highest chance of ROSC?

Researchers will compare different levels of ventilation rates and volumes that are blindly measured during CPR to see how the observed rates and volumes are associated with survival outcomes and complications.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

900

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Kasper G Lauridsen, MD, PhD
  • Phone Number: +45 78 42 00 00
  • Email: kglerup@clin.au.dk

Study Locations

  • Denmark
      • Aabenraa, Denmark
      • Aalborg, Denmark, 9000
        • Recruiting
        • Aalborg University Hospital
        • Contact:
          • Thomas L Klitgaard
          • Phone Number: +45 97 66 00 00
          • Email: tlk@rn.dk
        • Contact:
          • Steen Kåre Stokbro Fagerberg
          • Phone Number: +45 97 66 00 00
          • Email: s.fagerberg@rn.dk
      • Aarhus, Denmark, 8200
        • Recruiting
        • Aarhus University Hospital
        • Contact:
      • Esbjerg, Denmark, 6700
      • Gødstrup, Denmark, 7400
        • Recruiting
        • Gødstrup Hospital
        • Contact:
      • Hjørring, Denmark, 9800
        • Recruiting
        • North Denmark Region Hospital - Hjørring
        • Contact:
          • Cecilie Overgaard Nielsen
          • Phone Number: +45 97 64 00 00
          • Email: cenie@rn.dk
      • Horsens, Denmark, 8700
        • Recruiting
        • Horsens Regional Hospital
        • Contact:
          • Lisa F Irion
          • Phone Number: +45 7842 5000
          • Email: LISIRI@rm.dk
      • Odense, Denmark, 5000
        • Recruiting
        • Odense University Hospital
        • Contact:
        • Contact:
      • Randers, Denmark, 8930
        • Recruiting
        • Randers Regional Hospital
        • Contact:
      • Viborg, Denmark, 8800
  • Norway
      • Trondheim, Norway, 7006
        • Recruiting
        • St. Olavs Hospital, Trondheim University Hospital
        • Contact:
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Adult patients receiving ventilation with a bag-valve-mask (BVM) or advanced airway during cardiopulmonary resuscitation for in-hospital cardiac arrest.

Description

Inclusion Criteria:

  1. In-hospital cardiac arrest
  2. Age ≥ 18 years
  3. >1minute of recorded ventilation data

Exclusion Criteria:

  1. Documented do-not-attempt cardiopulmonary resuscitation order
  2. Invasive mechanical circulatory support at the time of the cardiac arrest

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Study cohort

Adult patients (≥18 years) with in-hospital cardiac arrest receiving cardiopulmonary resuscitation.

Groups will be defined based on observed distribution of ventilation parameters (ventilation rate, tidal volume and minute ventilation).
Other: Positive pressure ventilation during cardiopulmonary resuscitation

The primary exposures of interest are the observed ventilation rate, tidal volume and minute ventilation during cardiopulmonary resuscitation.

Ventilation data are obtained by inspiratory and expiratory air flow measurements using the EOlife (Archeon, Besançon, France) to which healthcare providers are blinded.

Other Names:
  • manual ventilation
  • artificial ventilation
  • intra-arrest ventilation
  • bag-valve-mask ventilation
  • invasive ventilation

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Fraction of patients with return of spontaneous circulation (ROSC)
Time Frame: ROSC is assessed immediately following cardiopulmonary resuscitation.
ROSC is defined as sustained spontaneous circulation with no need for chest compressions for at least 20 minutes.
ROSC is assessed immediately following cardiopulmonary resuscitation.

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Fraction of patients surviving until day 30
Time Frame: Assessed at day 30 after cardiac arrest.
Patient survival for at least 30 days following cardiac arrest.
Assessed at day 30 after cardiac arrest.

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Fraction of patients with pulmonary complications
Time Frame: From date of ROSC until date of intensive care unit discharge or date of death from any cause, whichever came first, assessed up to 30 days.
Composite endpoint of pulmonary complications after return of spontaneous circulation (ROSC) including acute respiratory distress syndrome (ARDS), aspiration, pneumothorax and hemothorax.
From date of ROSC until date of intensive care unit discharge or date of death from any cause, whichever came first, assessed up to 30 days.
Number of days alive without mechanical ventilation
Time Frame: From date of ROSC until day 30 or date of death from any cause, whichever came first.
Days patients are alive without receiving mechanical ventilation after return of spontaneous circulation (ROSC).
From date of ROSC until day 30 or date of death from any cause, whichever came first.
Number of days alive outside the intensive care unit
Time Frame: From date of ROSC until day 90 or date of death from any cause, whichever came first.
Days patients are alive outside of the intensive care unit after return of spontaneous circulation (ROSC).
From date of ROSC until day 90 or date of death from any cause, whichever came first.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Aarhus

Investigators

  • Principal Investigator: Johannes Wittig, MD, Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark
  • Principal Investigator: Kasper G Lauridsen, MD, PhD, Department of Clinical Medicine, Aarhus University, Denmark; Department of Medicine, Randers Regional Hospital, Randers, Denmark; Research Center for Emergency Medicine, Aarhus University Hospital, Denmark;

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 1, 2025

Primary Completion (Estimated)

April 1, 2027

Study Completion (Estimated)

June 1, 2027

Study Registration Dates

First Submitted

January 20, 2025

First Submitted That Met QC Criteria

January 29, 2025

First Posted (Actual)

February 5, 2025

Study Record Updates

Last Update Posted (Actual)

March 30, 2026

Last Update Submitted That Met QC Criteria

March 27, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • VENT-IHCA
  • 1-16-02-301-24 (Registry Identifier: Internal Registry Central Denmark Region)
  • 2022-0367531 (Registry Identifier: Internal Research Registry Aarhus University)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

The investigators are not permitted to share IPD.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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