Effects of Platelet-Rich Fibrin and Kinesio Taping on Postoperative Recovery in Oral Surgery (PRFKTOralSur)

Effectiveness of Platelet-Rich Fibrin and Elastic Bandaging on Postoperative Pain, Edema, and Recovery Following Impacted Molar Surgery: A Randomized Clinical Trial

This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in reducing postoperative pain, edema, and improving recovery following impacted third molar surgery. A prospective, randomized clinical trial was conducted with 44 patients aged 18-35 years. Patients were assigned to three groups: (1) PRF applied locally to the extraction socket, (2) Kinesio Taping applied postoperatively and removed on the third day, and (3) a control group receiving standard postoperative care. Postoperative outcomes were assessed on days 3 and 7, including pain levels, edema, and quality of life. This study aims to evaluate PRF and Kinesio Taping as non-pharmacological adjuncts in oral and maxillofacial surgery.

Study Overview

• Status: Completed
• Conditions: Postoperative Pain; Postoperative Edema; Impacted Third Molar Tooth
• Intervention / Treatment: Biological: Platelet-Rich Fibrin (PRF); Device: Kinesio Taping; Other: Standard Postoperative Care

Detailed Description

This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in postoperative management following impacted mandibular third molar surgery. Postoperative complications, such as pain and edema, are commonly observed and may impact patient comfort and recovery. This study aims to evaluate the feasibility of two non-pharmacological approaches-PRF and Kinesio Taping (Elastic Bandaging)-in postoperative care.

A total of 44 patients aged 18-35 years participated in this prospective, randomized clinical trial. Patients were assigned to one of three groups:

PRF Group: Platelet-rich fibrin (PRF) was applied locally into the extraction socket.

Kinesio Taping Group: An elastic bandage was applied postoperatively to the surgical area and removed on the third day.

Control Group: Standard postoperative care was provided with no additional intervention.

Postoperative evaluations were conducted on the 3rd and 7th days. The measured parameters included:

Edema: Measured using anthropometric techniques.

Pain: Assessed with the Numerical Rating Scale (NRS).

Quality of Life: Evaluated using the Oral Health Impact Profile-14 (OHIP-14).

This study aims to assess the feasibility of PRF and Kinesio Taping in postoperative management.

• Study Type: Interventional
• Enrollment (Actual): 44
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey
  • Hatay, Turkey, 31001
    • Hatay Mustafa Kemal University, Faculty of Dentistry

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Ages 18-35 years
• Systemically healthy individuals
• Non-smokers
• No psychological disorders
• Preoperative pain level between 0-3 on the Numerical Rating Scale (NRS)
• No preoperative edema in the surgical area
• Impacted mandibular third molars classified as Class 1 or 2, Level B, and mesioangular according to the Pell-Gregory classification
• Signed an informed consent form

Exclusion Criteria:

• Under 18 or over 35 years old
• Presence of chronic or systemic diseases
• Pregnant or breastfeeding patients
• Surgical duration exceeding 45 minutes
• Smokers
• Patients requiring prophylactic antibiotics due to systemic health conditions
• Patients who did not meet the study criteria or did not sign the informed consent form

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: PRF Group; Participants in this group received Platelet-Rich Fibrin (PRF) applied to the extraction socket following impacted third molar surgery. PRF was prepared using a centrifugation protocol and placed into the surgical site.	Biological: Platelet-Rich Fibrin (PRF); PRF was prepared using a centrifugation protocol and applied to the extraction socket.
Experimental: Kinesio Taping Group; Participants in this group received Kinesio Taping applied postoperatively. The elastic therapeutic tape was applied to the masseter and submandibular region following a standardized taping protocol.	Device: Kinesio Taping; Kinesio Tape was applied postoperatively to the masseter and submandibular region.
Other: Control Group; Participants in this group received standard postoperative care, including routine pain management and wound care, without additional interventions.	Other: Standard Postoperative Care; Patients in the control group received standard postoperative care.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Postoperative Pain Assessment (NRS)	The pain intensity of the patients will be assessed using the Numerical Rating Scale (NRS) on preoperative day 1 and postoperative days 3 and 7. On this scale: 0 indicates no pain, 10 indicates the worst imaginable pain. Before the procedure, patients were informed about the scale and instructed to rate their pain intensity accordingly.	Preoperative day 1, postoperative days 3 and 7
Postoperative Facial Swelling Assessment	Swelling will be evaluated using anthropometric measurement techniques on preoperative (surgery day), postoperative days 1, 3, and 7. Measurement methods: Lateral canthus-gonion distance (distance from the outer corner of the eye to the mandibular angle) Commissure-tragus distance (distance from the oral commissure to the midpoint of the tragus) All measurements were performed using a flexible ruler, and the results were recorded in millimeters.	Preoperative day 1, postoperative days 3 and 7
Oral Health Impact Profile-14 (OHIP-14) Score	The quality of life of the patients will be assessed using the OHIP-14 questionnaire on postoperative days 3 and 7. OHIP-14 consists of 14 standardized items, each rated on a scale from 0 to 4. Total scores range from 0 to 56, with higher scores indicating worse quality of life. This scale was used to evaluate the impact of postoperative complications on patients' quality of life.	Postoperative days 3 and 7

Collaborators and Investigators

• Sponsor: Mustafa Kemal University
• Investigators: Principal Investigator: züleyha başar karakuzu, DDS, Mustafa Kemal University

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2023
• Primary Completion (Actual): January 10, 2024
• Study Completion (Actual): May 21, 2024

Study Registration Dates

• First Submitted: March 17, 2025
• First Submitted That Met QC Criteria: March 22, 2025
• First Posted (Actual): March 28, 2025

Study Record Updates

• Last Update Posted (Actual): April 2, 2025
• Last Update Submitted That Met QC Criteria: March 28, 2025
• Last Verified: March 1, 2025

More Information

Terms related to this study

• Keywords: quality of life; postoperative pain; platelet-rich fibrin; Impacted third molar; elastic bandage; Postoperative Edema
• Additional Relevant MeSH Terms: Pain; Neurologic Manifestations; Stomatognathic Diseases; Postoperative Complications; Pathologic Processes; Tooth Diseases; Pain, Postoperative; Edema; Tooth, Impacted
• Other Study ID Numbers: PRF_KT2025; Ethics Committee No. (Registry Identifier: Hatay Clinical Research Ethics Committee - 2023/03)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: The individual participant data (IPD) collected during the study will not be shared due to confidentiality and ethical considerations. Data will only be used for statistical analysis and publication purposes in an aggregated and anonymized form.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No