A Look Back at How Well Interventional Treatments Work for Bronchopleural Fistulas in Patients With Lung Metastases From Osteosarcoma

A Retrospective Study on the Efficacy of Interventional Treatment for Bronchopleural Fistula Related to Pulmonary Metastasis of Osteosarcoma

Patients with pulmonary metastasis of osteosarcoma complicated with BPF often suffer from massive hemoptysis, refractory pneumothorax and difficult fistula healing due to tumor erosion of bronchial arteries. Traditional interventional embolization (such as simple coil or gelatin sponge embolization) has some limitations such as embolic material displacement, incomplete fistula closure and postoperative recurrent bleeding. Systemic chemotherapy and radiotherapy also have poor efficacy due to the complex blood supply of local lesions and poor tissue repair ability, and the quality of life of patients is seriously impaired. Therefore, there is an urgent need to explore a safer and durable precise embolization scheme.

NBCA combined with coil closure is expected to break through the current technical bottleneck through the synergistic mechanism of "colloid embolization + mechanical occlusion". NBCA glue can quickly polymerize to achieve permanent occlusion of the micro vascular network, while the coil can strengthen the fistula through physical support. The combination of the two can not only accurately block abnormal blood supply, promote fistula healing, but also reduce the risk of embolus displacement and hemoptysis recurrence rate. This study is the first to systematically evaluate the efficacy and safety of this combination regimen in such patients, and provide key evidence for optimizing the embolization strategy and improving the long-term prognosis.

The clinical transformation value and social significance of this study are significant. If NBCA combined with coil is proved to be effective in controlling bleeding, shortening fistula closure time and reducing complications, it will promote this technology to become the first choice for advanced osteosarcoma pulmonary metastasis with complex fistula. Its minimally invasive and repeatability can help to reduce the frequency of repeated hospitalization and the risk of infection, save medical resources, and provide new ideas for the exploration of multimodal embolization techniques in interventional medicine, which has a profound impact on improving the quality of life of patients with end-stage cancer.

Study Overview

• Status: Not yet recruiting
• Conditions: Osteosarcoma Metastatic
• Intervention / Treatment: Procedure: Interventional therapy

• Study Type: Observational
• Enrollment (Estimated): 28

Contacts and Locations

• Study Contact: Name: Zhongmin Wang; Phone Number: +8613901848333; Email: wzm11896@rjh.com.cn
• Study Contact Backup: Name: Yuyue Jiang; Phone Number: +8617612235502; Email: jyy2052@163.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

From January 1, 2019 to December 31, 2023, patients with pulmonary metastasis of osteosarcoma complicated with BPLF who underwent interventional treatment in the hospital were enrolled.

Description

Inclusion Criteria:

• The patient was diagnosed with osteosarcoma by histology or cytology, and pulmonary metastasis with bronchopleural fistula (BPF) was confirmed by imaging (CT/PET-CT);
• Present with clinical symptoms associated with BPF (e.g., hemoptysis, pneumothorax, persistent pleural infection, etc.) that are ineffective or poorly responded to traditional treatments (pharmacologic hemostasis, closed thoracic drainage);
• Angiographically confirmed abnormal bronchial or intercostal artery blood supply to the fistula and anatomy suitable for NBCA with coil embolization;
• Age ≤75 years, ECOG performance status ≤2, and predicted survival ≥3 months.
• Coagulation function was basically normal.

Exclusion Criteria:

• Had a history of severe allergy or contraindication to NBCA glue, iodine contrast agent or coil materials;
• Severe cardiopulmonary dysfunction (e.g., NYHA class III-IV, FEV1 < 30% predicted, uncontrolled pulmonary hypertension);
• Angiographic abnormalities of the target vessel anatomy (e.g., severe tortuosity, stenosis, or occlusion) prevented the catheter from safely reaching the target embolization site;
• Active systemic infection (e.g., sepsis, active tuberculosis) or uncontrolled local infection;
• Other major organ failure (Child-Pugh C cirrhosis, eGFR < 30 mL/min/1.73m²);
• Women who are pregnant or lactating or plan to become pregnant during the study.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Interventional THERAPY Group; Patients undergoing interventional therapy	Procedure: Interventional therapy; The fistula was occluded by coil and NBCA glue.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
OS，Overall Survival	The patient received treatment until death.	From the time of treatment to the death from any cause, assessed up to 50 months.
PFS，Progress Free Survival	Time of progression or death of the patient.	From the time of treatment to tumor progression or date of death from any cause, whichever came first, assessed up to 50 months

Collaborators and Investigators

• Sponsor: Ruijin Hospital

Study record dates

Study Major Dates

• Study Start (Estimated): May 1, 2025
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026

Study Registration Dates

• First Submitted: April 7, 2025
• First Submitted That Met QC Criteria: April 14, 2025
• First Posted (Actual): April 15, 2025

Study Record Updates

• Last Update Posted (Actual): April 15, 2025
• Last Update Submitted That Met QC Criteria: April 14, 2025
• Last Verified: April 1, 2025

More Information

Terms related to this study

• Keywords: Interventional therapy; Bronchopleural fistula; Pulmonary metastasis of osteosarcoma
• Additional Relevant MeSH Terms: Pathologic Processes; Neoplasms; Pathological Conditions, Anatomical; Neoplasms by Histologic Type; Neoplastic Processes; Sarcoma; Neoplasms, Connective and Soft Tissue; Neoplasms, Bone Tissue; Neoplasms, Connective Tissue; Neoplasm Metastasis; Osteosarcoma; Fistula
• Other Study ID Numbers: 2025-173

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No