Efficacy of Genicular Block on Total Knee Arthroplasty Surgery

Assesment of Postoperative Analgesic Efficacy of Preoperatively Applied Genicular Block on Total Knee Arthroplasty: A Randomized Controlled Study

The aim of this study is to investigate the postoperative pain relieving effect of preoperative genicular block in total knee arthroplasty surgery. The main questions it aims to answer are:

1. Do visual analog scale (VAS) scores decrease in patients who underwent geniculate block?
2. Does opioid consumption decrease in patients who underwent geniculate block?

Researchers will compare postoperative pain in patients who received genicular block with those who did not.One group of patients will be administered 0.25% bupivacaine with the geniculate block method. The other group will not undergo any intervention. Both groups will be administered intravenous morphine for postoperative analgesia.

Study Overview

• Status: Not yet recruiting
• Conditions: Total Knee Anthroplasty; Genicular Nerves Block
• Intervention / Treatment: Drug: Genicular blocks (bupivakain); Drug: Paracetamol (acetaminophen) + Diclofenac Sodium; Drug: Patient Control Analgesia (PCA) Morphine group

Detailed Description

Patients scheduled for knee arthroplasty will be randomly assigned into two groups. One group will receive a genicular nerve block prior to surgery , while the other group will not undergo any interventional procedure. The genicular nerve block will be administered in three quadrants around the knee, with each injection consisting of 5 mL of 0.25% Marcaine. All injections will be performed by investigator MA. Patient assessments will be conducted by investigator MO. Postoperative intravenous analgesia will be provided to both groups.

• Study Type: Interventional
• Enrollment (Estimated): 44
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Mustafa Azizoglu, Associated Professor; Phone Number: +90 5325667061; Email: dryalamaoglu@hotmail.com
• Study Contact Backup: Name: Mervenur Ozturk, Resident Doctor; Phone Number: +90 5525345189; Email: mervenurnurozturk@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Scheduled for unilateral and primary total knee arthroplasty
• Older than 18 years of age

Exclusion Criteria:

• Younger than 18 years
• Bilateral knee arthroplasty
• Revision case of knee arthroplasty

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Genicular block group; this group consists of the patients receiving genicular block preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed)	Drug: Genicular blocks (bupivakain); Genicular block is a regional analgesic technique performed with USG; Drug: Paracetamol (acetaminophen) + Diclofenac Sodium; All patients are given paracetamol (3x1000 mg) and diclofenac (if needed); Drug: Patient Control Analgesia (PCA) Morphine group; this group consists of the patients no any intervention preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed); Other Names: PCA-M
Active Comparator: patients only given PCA-morfin postoperatively; this group consists of the patients given morfin with PCA, paracetamol 3x1000 mg and diclofenac (if needed)	Drug: Paracetamol (acetaminophen) + Diclofenac Sodium; All patients are given paracetamol (3x1000 mg) and diclofenac (if needed); Drug: Patient Control Analgesia (PCA) Morphine group; this group consists of the patients no any intervention preoperatively and they will be given morfin with PCA (Patient controlled analgesia) and paracetamol 3x1000 mg intravenous and diclofenac 75 mg intramuscular (if needed); Other Names: PCA-M

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
opioid consumption	Morphine consumption is assesed by PCA	0-48 hours
Visual Analog Scale Measure	VAS scores are assessed at 0th, 24th and 48th hours post operatively VAS score consists of 0-10 in numbers, the bigger the number the worse the pain	0-48 hours

Collaborators and Investigators

• Sponsor: Mersin University
• Investigators: Principal Investigator: Mustafa Azizoglu, Associated Professor, Mersin university Faculty of Medicine, Department of Anesthesiology and Reanimation

Publications and helpful links

General Publications

• Wang T, Leng YF, Zhang Y, Kang YQ, Xue X, Zhang Y. [Preventive effects of ischemic postconditioning and penehyclidine hydrochloride on gastric against ischemia-reperfusion injury in rats]. Zhonghua Yi Xue Za Zhi. 2011 Apr 26;91(16):1130-5. Chinese.

Study record dates

Study Major Dates

• Study Start (Estimated): May 20, 2026
• Primary Completion (Estimated): August 15, 2026
• Study Completion (Estimated): December 20, 2026

Study Registration Dates

• First Submitted: April 17, 2025
• First Submitted That Met QC Criteria: April 17, 2025
• First Posted (Actual): April 24, 2025

Study Record Updates

• Last Update Posted (Actual): May 19, 2026
• Last Update Submitted That Met QC Criteria: May 15, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Keywords: total knee arthroplasty; postoperative pain; genicular block
• Additional Relevant MeSH Terms: Pain; Neurologic Manifestations; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Pain, Postoperative; Organic Chemicals; Investigative Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Carboxylic Acids; Anilides; Amides; Aniline Compounds; Amines; Acetanilides; Acids, Carbocyclic; Immunologic Techniques; Phenylacetates; Immunologic Tests; Skin Tests; Immune System Phenomena; Antigen-Antibody Reactions; Acetaminophen; Diclofenac; Passive Cutaneous Anaphylaxis
• Other Study ID Numbers: MersinUgenicular

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: Individual participant data (IPD) will not be shared due to ethical considerations and institutional policies on patient confidentiality.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No