Nutritional Status and Patient Characteristics Upon Length of Stay, Clinical Outcome, and Survival in Older Hospitalized Patients (INSIGHT)

The Influence of Nutritional Status and Phenotypic Characteristics Upon Length of Stay, Clinical Outcome, and Survival in Hospitalized Patients

Disease-related malnutrition (DRM) describes undernutrition or imbalances in energy, protein, or other nutrient-needs, caused by a concomitant disease. Nutritional status plays a vital role in the fate of hospitalized patients, and DRM is associated with loss of function and decreased survival.

DRM is a common condition in patients with acute illnesses, approximately 30% among medical inpatients are malnourished when admitteed to the hospital, and rise higher among the older or critically ill. Physiologically malnutrition is associated with a) poorer tissue healing and restitution after severe disease, b) suppressed immune function and resistance towards infections, c) poorer metabolic defense towards critical disease, d) delayed and poorer progress of chronic diseases. In addition, inadequate nutrition is coupled to a prolonged hospital stay, resulting in more readmissions, and overall higher mortality in hospital patients. Yet, nutritional status of patients upon hospital admittance is seldom systematically assessed and the consequences of DRM in older acutely admitted patients still needs to be understood.

This project will provide a detailed description of nutritional, physiolgical, and biochemical status of 1500 acutely admitted patients. In relation, the study will investigate the relation between patient characteristics and disease progression. The obtained data will also be coupled to patient registers to investigate the link between length of hospital stay, readmissions and acute contact, and mortality.

Study Overview

• Status: Recruiting
• Conditions: Malnutrition; Geriatric; Length of Stay
• Intervention / Treatment: Other: Exposures and measurements

• Study Type: Observational
• Enrollment (Estimated): 1500

Contacts and Locations

• Study Contact: Name: Jacob B Jespersen, MSc; Phone Number: +4522321355; Email: jacob.baekgaard.jespersen@regionh.dk

Study Locations

• Denmark
  • Copenhagen, Denmark, 2400
    • Recruiting
    • Bispebjerg Hospital
    • Contact: Jacob Jespersen; Phone Number: +4522321355; Email: jacob.baekgaard.jespersen@regionh.dk

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Patients acutely admitted at Bispebjerg Hospital

Description

Inclusion Criteria:

• Acutely admitted adults aged 65 years and above.
• Be able to comply with the study information, as assessed by the research personnel.
• Be able to understand Danish.

Exclusion Criteria:

• <24 hours admission
• Terminal illness in end stage of life
• Patients with temporary civil person registration number (CPR)

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Intervention / Treatment

The INSIGHT cohort; A geriatric cohort (age ≥ 65) established to investigate the coupling of phenotypical characteristics to nutritional and physiological status. The study intent to explore whether Disease-Related Malnutrition provides predictive value for patient prognosis based on specific phenotypic characteristics and establish different physiological stratifications to improve the identification of acutely admitted patients.

Other: Exposures and measurements; Anthropometry, Body composition (BIA), Nutritional screening (GLIM, SNAQ, NIS, NRS-2002), Functional tests, Seisomocardiography, Muscle strength, Blood tests, Fecal swabs, Indirect calorimetry Orientation-Memory-Concentration (OMC), Sarcopenia, Frailty (Clinical Frailty Scale), Comobidity, Polypharmacy, Portrait photo.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Length of Hospital Stay	Time (in hours) hospitalized from arrival to discharge	From date of hospital admission untill discharge, assessed up to 2 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mortality	Time to mortality from index admission	Time to mortality 90 days from index admission
Readmission	Time to readmission from discharge	Time to readmission 30 days from discharge
Acute contact	Time to acute contact from discharge	Time to acute contact 30 days from discharge

Collaborators and Investigators

• Sponsor: Bispebjerg Hospital

Study record dates

Study Major Dates

• Study Start (Actual): May 12, 2025
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): November 1, 2028

Study Registration Dates

• First Submitted: April 25, 2025
• First Submitted That Met QC Criteria: April 25, 2025
• First Posted (Actual): April 27, 2025

Study Record Updates

• Last Update Posted (Actual): May 14, 2025
• Last Update Submitted That Met QC Criteria: May 12, 2025
• Last Verified: May 1, 2025

More Information

Terms related to this study

• Keywords: Nutritional status; Geriatric; Physiology; Deep phenotyping; Disease-related malnutrition; Acute illness
• Additional Relevant MeSH Terms: Nutrition Disorders; Malnutrition
• Other Study ID Numbers: H-25009586

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: The following will be available: Study Protocol and Statistical Analysis Plan (SAP).

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No